Title: Book the Best San Luis LUXURY Hotels - Upscale Hotels in San Luis, AZ | Expedia.ca [Hotels in San Luis](https://expedia.ca/San-Luis-Hotels.d553248634983175106.Travel-Guide-Hotels)[Vacation Rentals in San Luis](https://expedia.ca/San-Luis-Vacation-Rentals.d553248634983175106.Travel-Guide-VacationRentals)[San Luis Car Rentals](https://expedia.ca/Car-Rentals-In-San-Luis.d553248634983175106.Car-Rental-Guide)[San Luis Vacation Packages](https://expedia.ca/San-Luis.d553248634983175106.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in San Luis, AZ - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on San Luis Luxury Hotels Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=553248634983175106&startDate=2025-11-04&endDate=2025-11-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=553248634983175106&startDate=2025-11-05&endDate=2025-11-06&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248634983175106&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248634983175106&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top San Luis Luxury Hotels ## Top San Luis Hotel Reviews ![Historic Coronado Motor Hotel by OYO](//images.trvl-media.com/lodging/1000000/10000/3200/3162/f8dcd2a0_y.jpg) ### Historic Coronado Motor Hotel by OYO 10/10 Excellent "There were multiple buildings at the Coronado The one we stayed in had an unkempt parking lot. A man sat on a stump in front of our car drinking a bottle of whiskey for several hours He has company for part of the time The door to our room didn’t lock and there was a big space under the door There was a stain on the sheets We slept on top of the covers and barely slept wondering whether our car or our room would be broken into. " [](https://expedia.ca/Yuma-Hotels-Historic-Coronado-Motor-Hotel.h3162.Hotel-Information) ![Motel 6 Yuma, AZ - East](//images.trvl-media.com/lodging/2000000/1040000/1037800/1037701/e9d2c60a_y.jpg) ### Motel 6 Yuma, AZ - East 10/10 Excellent "I had no problems" [](https://expedia.ca/Yuma-Hotels-Motel-6-Yuma.h1037701.Hotel-Information) ![La Fuente Inn & Suites](//images.trvl-media.com/lodging/1000000/60000/50100/50057/c30df864_y.jpg) ### La Fuente Inn & Suites 10/10 Excellent "The hotel was great, breakfast, service and overall all was a good choice. " [](https://expedia.ca/Yuma-Hotels-La-Fuente-Inn-Suites.h50057.Hotel-Information) ![Wingate by Wyndham Yuma](//images.trvl-media.com/lodging/2000000/1830000/1820800/1820795/bb3f13a6_y.jpg) ### Wingate by Wyndham Yuma 10/10 Excellent "Clean rooms, clean facility, good location and friendly staff." [](https://expedia.ca/Yuma-Hotels-Wingate-By-Wyndham-Yuma.h1820795.Hotel-Information) ![Radisson Hotel Yuma](//images.trvl-media.com/lodging/3000000/2410000/2410000/2409993/a84bae03_y.jpg) ### Radisson Hotel Yuma 10/10 Excellent "This hotel was very clean and the staff were friendly, the complementary breakfast buffet was delicious. " [](https://expedia.ca/Yuma-Hotels-Radisson-Hotel-Yuma.h2409993.Hotel-Information) ![Shilo Inn Hotel & Suites - Yuma](//images.trvl-media.com/lodging/1000000/10000/8500/8427/457051a1_y.jpg) ### Shilo Inn Hotel & Suites - Yuma 10/10 Excellent "Great place to stay with friendly staff" [](https://expedia.ca/Yuma-Hotels-Shilo-Inn-Hotel-Suites-Yuma.h8427.Hotel-Information) ![Days Inn by Wyndham Yuma](//images.trvl-media.com/lodging/1000000/20000/16900/16837/071aaafc_y.jpg) ### Days Inn by Wyndham Yuma 10/10 Excellent "Really nice stay for the right price!" [](https://expedia.ca/Yuma-Hotels-Days-Inn-By-Wyndham-Yuma.h16837.Hotel-Information) ## Frequently asked questions ### Are you searching for the perfect hotel for your luxury trip to San Luis? > Use Expedia to arrange your flight to Yuma Intl. Airport (YUM) airport or Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a vacation, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want a posh hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that San Luis has to offer. San Luis has some interesting things to see and do including Colorado River and San Luis Lakes State Park, so you might want to take in the local sights during your visit. ### When can I expect good weather in San Luis? > Planning for the weather is an important factor for making your trip to San Luis a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 92°F, while the coldest months are December and January with an average of 61°F. Average annual precipitation for San Luis is 4 inches. ### What's there to see and do in San Luis? > Enjoy San Luis with a stop at Colorado River, San Luis Lakes State Park, and Garita Entrance to Mexico. 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