San Isidro Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $1,096 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your San Isidro Vacation

When a break in the city is calling, answer it with a San Isidro vacation package. The neighborhood of Flamenco, which is good for underwater activities, coastal beaches and nature, makes a fantastic base for your adventures. Fill your schedule with visits to Flamenco Beach, Culebrita Beach and Flamenco Peninsula, some of the things you should see during a trip to San Isidro. Browse Expedia's wide range of travel options and book your dream vacation to San Isidro now.

Top San Isidro Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Mamacita's Guest House

Ready to book your vacation to San Isidro?

 

Choose your dates

San Isidro Hotel Deals

Sea Gate Hotel

Sea Gate Hotel

2.5 out of 5
Route 989 Km .04 Vieques
The price is CA $145 per night from Apr 8 to Apr 9
CA $145
CA $168 total
Apr 8 - Apr 9
includes taxes & fees
9.6/10 Exceptional! (1,003 reviews)
The place is situated on top of a hill with good views of the ocean, relaxing environment. Nice rooms with good decor. Very helpful owner Penny and Kelly, who gave us a lot of useful information

Reviewed on Apr 4, 2026

Sea Gate Hotel
Old Crow Hotel and Suites

Old Crow Hotel and Suites

2.5 out of 5
Barrio Florida, Carr.201 km 1.3 Vieques Puerto Rico
The price is CA $202 per night from Apr 24 to Apr 25
CA $202
CA $231 total
Apr 24 - Apr 25
includes taxes & fees
8.8/10 Excellent! (224 reviews)
Love this place, great vibe

Reviewed on Mar 29, 2026

Old Crow Hotel and Suites
Mamacita's Guest House

Mamacita's Guest House

2.5 out of 5
Calle Castelar #64 Culebra
The price is CA $174 per night from Apr 9 to Apr 10
CA $174
CA $211 total
Apr 9 - Apr 10
includes taxes & fees
8/10 Very Good! (534 reviews)
The restaurant associated with this hotel had amazing food and views. The room was clean, the bathroom was updated, and the private balcony was nice to have morning coffee or dry your swimsuit. Situated close to a delicious breakfast restaurant, a 5 minute walk from the ferry, and a 10 minute golf ...

Reviewed on Apr 2, 2026

Mamacita's Guest House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.