Title: Book the Best Saint Charles LUXURY Hotels - Upscale Hotels in Saint Charles, IA | Expedia.ca

[Hotels in Saint Charles](https://expedia.ca/Saint-Charles-Hotels.d553248634983484134.Travel-Guide-Hotels)[Vacation Rentals in Saint Charles](https://expedia.ca/Saint-Charles-Vacation-Rentals.d553248634983484134.Travel-Guide-VacationRentals)[Saint Charles Car Rentals](https://expedia.ca/Car-Rentals-In-Saint-Charles.d553248634983484134.Car-Rental-Guide)[Saint Charles Vacation Packages](https://expedia.ca/Saint-Charles.d553248634983484134.Destination-Travel-Guides)

![cuttler-donahoe covered bridge, iowa](https://images.trvl-media.com/place/553248634983484134/d92bb5fd-1d76-4e51-9760-b83600e1444d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find luxury hotels in Saint Charles, IA

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## Check availability on Saint Charles Luxury Hotels

Tonight

[Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248634983484134&startDate=2025-12-27&endDate=2025-12-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Tomorrow

[Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=553248634983484134&startDate=2025-12-28&endDate=2025-12-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Next weekend

[Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=553248634983484134&startDate=2026-01-02&endDate=2026-01-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

In two weeks

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=553248634983484134&startDate=2026-01-09&endDate=2026-01-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

## Top Saint Charles Hotel Reviews

![Fairfield Inn and Suites by Marriott Des Moines West](https://images.trvl-media.com/lodging/1000000/80000/77600/77590/01d93670_y.jpg)

### Fairfield Inn and Suites by Marriott Des Moines West

10/10 Excellent

"Staff was very welcoming "

[](https://expedia.ca/Des-Moines-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Des-Moines-West.h77590.Hotel-Information)

![Days Inn & Suites by Wyndham Des Moines Airport](https://images.trvl-media.com/lodging/1000000/50000/49900/49826/23994ff1_y.jpg)

### Days Inn & Suites by Wyndham Des Moines Airport

10/10 Excellent

"Nothing bad to say at all"

[](https://expedia.ca/Des-Moines-Hotels-Days-Inn-Suites-By-Wyndham-Des-Moines-Airport.h49826.Hotel-Information)

![Motel 6 West Des Moines, IA](https://images.trvl-media.com/lodging/1000000/990000/986100/986072/e3428772_y.jpg)

### Motel 6 West Des Moines, IA

10/10 Excellent

"Nice clean room, friendly staff. "

[](https://expedia.ca/Des-Moines-Hotels-Motel-6-West-Des-Moines.h986072.Hotel-Information)

![Des Lux Hotel](https://images.trvl-media.com/lodging/10000000/9790000/9781500/9781455/e7f9fb30_y.jpg)

### Des Lux Hotel

10/10 Excellent

"Beautiful hotel!"

[](https://expedia.ca/Des-Moines-Hotels-Des-Lux-Hotel.h9781455.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Des Moines West Clive](https://images.trvl-media.com/lodging/1000000/60000/50200/50111/0778119f_y.jpg)

### La Quinta Inn & Suites by Wyndham Des Moines West Clive

10/10 Excellent

"All of the above. Can't say enough good about them. I've been burnt on a few different places and this place was awesome "

[](https://expedia.ca/Des-Moines-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Des-Moines-West-Clive.h50111.Hotel-Information)

![Comfort Inn & Suites Event Center](https://images.trvl-media.com/lodging/1000000/10000/8300/8217/a41cce84_y.jpg)

### Comfort Inn & Suites Event Center

10/10 Excellent

"Helpful front desk. Nice room but the toilet is very low to the ground! Hard on my knees!"

[](https://expedia.ca/Des-Moines-Hotels-Comfort-Inn-Suites-Event-Center.h8217.Hotel-Information)

![Hyatt Place Des Moines/Downtown](https://images.trvl-media.com/lodging/4000000/3980000/3972200/3972152/c5d9ac95_y.jpg)

### Hyatt Place Des Moines/Downtown

10/10 Excellent

"Staff very friendly at check in and helpful with parking issue. "

[](https://expedia.ca/Des-Moines-Hotels-Hyatt-Place-Des-Moines-Downtwn.h3972152.Hotel-Information)

## Frequently asked questions

### Are you looking for a luxury hotel for your Saint Charles vacation?

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