Title: Book the Best BUSINESS Hotels in Rancho Peñasquitos in 2025 | Expedia.ca [Rancho Peñasquitos Travel Guide](https://expedia.ca/San-Diego-Rancho-Penasquitos.dx553248635074841857)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Rancho Peñasquitos Car Rentals](https://expedia.ca/Car-Rentals-In-Rancho-Penasquitos.d553248635074841857.Car-Rental-Guide)[Rancho Peñasquitos Vacations](https://expedia.ca/Rancho-Penasquitos.d553248635074841857.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/9707b2317db01ebca14029c65e5a73b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Amy X # Find Business Hotels in Rancho Peñasquitos, CA from CA $129 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Rancho Peñasquitos Business Hotels Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=553248635074841857&startDate=2025-11-04&endDate=2025-11-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=553248635074841857&startDate=2025-11-05&endDate=2025-11-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635074841857&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635074841857&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Rancho Peñasquitos Business Hotels ![Reception](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/49f2cd82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/4b32319c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/0d512cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/e913facd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego - Miramar Rancho Peñasquitos 7.6/10 Good (1063) "Staff was friendly and very inviting. Would definitely stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gabriela CA $113 CA $129 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/San-Diego-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Miramar.h5684.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/f294be65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/16da1e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/d3b44b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/1b688cf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza San Diego - Mission Valley by IHG Mission Valley 7.8/10 Good (1083) "It was a very beautiful hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rafael CA $127 CA $146 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, City View](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1bec6ce5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/66a8936b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/3eeea039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/93e1ed0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection Downtown San Diego 8.8/10 Excellent (610) "It was a good stay for a night, check-in and check-out went well! I would stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ehsan CA $145 CA $168 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/9000000/8810000/8803100/8803093/c5ffd6ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/9000000/8810000/8803100/8803093/1fd6277d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/9000000/8810000/8803100/8803093/04976fb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/9000000/8810000/8803100/8803093/e3114fba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Carlsbad by IHG Bressi Ranch 9.0/10 Wonderful (1030) "Nice breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike CA $136 CA $153 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Carlsbad-Hotels-Holiday-Inn-Carlsbad.h8803093.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/41a32bda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/2fae8516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/3285daa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (USD 32.95 per person)](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/ce36ab32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Manchester Grand Hyatt San Diego Downtown San Diego 9.0/10 Wonderful (2856) "Great staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason CA $266 CA $384 total includes taxes & fees Nov 26 - Nov 27 [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/76b78879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/143ad063.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/c3607c60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/32f849c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden San Diego Near SeaWorld Point Loma 7.4/10 Good (4075) "Super friendly staff and hotel was clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) dulce CA $119 CA $137 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-Garden-San-Diego-Near-SeaWorld.h40962.Hotel-Information) ![8 outdoor pools, open 9:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/60000/60000/59916/ee70bfa4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/60000/60000/59916/cf5a1bfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/60000/60000/59916/9ea305ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/60000/60000/59916/c228c245.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Vacation Club at The Welk, San Diego Area Lawrence Welk Resort Village 8.2/10 Very good (1525) "Beautiful property with friendly staff and comfortable rooms. We enjoyed our stay and would recommend to others!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Kaitlyn CA $162 CA $231 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/Escondido-Hotels-Hyatt-Vacation-Club-At-The-Welk.h59916.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/5619e933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/676f55ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/1f20ac82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bay Club Hotel & Marina Point Loma 9.0/10 Wonderful (3070) "Clean & relaxing place with lovely staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shida CA $157 CA $180 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/5afe6cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/bb467cf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/b3ef3ceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/ad83f8b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton San Diego - Del Mar Carmel Valley 8.2/10 Very good (1757) "Clean and comfortable stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cindy CA $172 CA $196 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/e9d3f965.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/fcaa8786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/de4da698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/8f9c8a5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Republic San Diego, Autograph Collection Downtown San Diego 9.0/10 Wonderful (1154) "I loved that the rooms were clean, modern, and quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shirley CA $190 CA $261 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/San-Diego-Hotels-Hotel-Republic-San-Diego.h898447.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-19&endDate=2025-11-20®ionId=553248635074841857&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Rancho Peñasquitos Hotel Reviews ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Amazing! " [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![DoubleTree by Hilton San Diego - Del Mar](//images.trvl-media.com/lodging/1000000/20000/15300/15236/5afe6cec_y.jpg) ### DoubleTree by Hilton San Diego - Del Mar 10/10 Excellent "I refer to the restaurant as the "Chum Bucket". It is a small afterthought aside from the lobby. The place has maybe a smaller menu than a Del Mar roach coach." [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "The room and service was excellent. " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Clean room, friendly staff, and great service." [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Sheraton Mission Valley San Diego Hotel](//images.trvl-media.com/lodging/1000000/20000/11800/11725/f387ad25_y.jpg) ### Sheraton Mission Valley San Diego Hotel 10/10 Excellent "Everything was great!!" [](https://expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) ![Comfort Inn Sea World Area](//images.trvl-media.com/lodging/1000000/550000/544700/544662/44f458a2_y.jpg) ### Comfort Inn Sea World Area 10/10 Excellent "Very clean rooms and very accessible. Loved it." [](https://expedia.ca/San-Diego-Hotels-Comfort-Inn-Sea-World-Area.h544662.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Airport shuttle was the best. Rooms are ok with nice views. " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Beautiful location and loved the pools." [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Great room and great staff! They really made our stay with their hospitality and efficiency. " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in Rancho Peñasquitos with Expedia? > With top amenities like meeting rooms, laundry facilities and free parking, our business-friendly hotels come with all you'll need to settle that big contract — and then relax! Enter your destination and preferred travel dates and Expedia will help you do the rest. ### How can I find cheap business-friendly hotels in Rancho Peñasquitos? > When work takes you to Rancho Peñasquitos, our "business friendly" filter will help you find the right hotel. From WiFi to meeting rooms and work desks, they come with the amenities you need to do your job. 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