Title: Hotels by Independent in Puxico from CA $104 | Expedia.ca [Puxico Travel Guide](https://expedia.ca/Puxico.dx553248634983343452)[Hotels in Puxico](https://expedia.ca/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[Vacation Rentals in Puxico](https://expedia.ca/Puxico-Vacation-Rentals.d553248634983343452.Travel-Guide-VacationRentals)[Flights to Puxico](https://expedia.ca/Cheap-Flights-To-Puxico.d553248634983343452.Travel-Guide-Flights)[Puxico Car Rentals](https://expedia.ca/Car-Rentals-In-Puxico.d553248634983343452.Car-Rental-Guide)[Puxico Vacation Packages](https://expedia.ca/Puxico.d553248634983343452.Destination-Travel-Guides) ![Great place for sunrises, Bald Eagles in the winter, and Milkyway shots. ](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Mike McClain # Find Hotels by Independent in Puxico from CA $104 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-15&endDate=2025-12-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Puxico Independent ![Breakfast area](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/f3b3697d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/1413eaea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/df5fef26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/w2304h1533x0y0-5c6ba836.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dexter Inn [](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) Dexter 7.0/10 Good (332) "Room was nice and spacious." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca CA $93 CA $104 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/a0829ae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/ac6df1a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/145de6a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/c0aef459.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EC Reed's Mercantile and Hotel [](https://www.expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) Marble Hill 9.6/10 Exceptional (83) "Cute room, great food, fun soda fountain and friendly owners! Will return! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leslie [](https://www.expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/111000000/110070000/110066600/110066526/cd49f35c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/111000000/110070000/110066600/110066526/260d1914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110070000/110066600/110066526/1198f66e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/111000000/110070000/110066600/110066526/bccf3a61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Charming-2-Bedroom-House-With-2-KING-BEDS-In-Pleasant-Poplar-Bluff.h110066526.Hotel-Information) Poplar Bluff 8.8/10 Excellent (9) "The house was very clean and nicely decorated. The huge TV in the living room was a plus and the mattress was very comfortable. We would stay again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian CA $138 CA $350 total includes taxes & fees Dec 27 - Dec 28 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Charming-2-Bedroom-House-With-2-KING-BEDS-In-Pleasant-Poplar-Bluff.h110066526.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/4b3fbea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Wappapello [](https://www.expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) Williamsville 10/10 Exceptional (1) "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dyann [](https://www.expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/de7e2348.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/eab48480.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, books](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/673a1325.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/d1a4afba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided [](https://www.expedia.ca/Secluded-In-The-Woods.h89701234.Hotel-Information) Greenville 10/10 Exceptional (5) "Quaint, cleanly and well thought out. Everything needed to relax and make one’s self at home. Thank you for the extra breakfast items and coffee left for the AM. I would return to enjoy this groovy little spot again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark H. CA $209 CA $349 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Secluded-In-The-Woods.h89701234.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/b507d487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/56368321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/51237f26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/6bc1352c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Chapel Cabin at Twin Bridges Campground [](https://www.expedia.ca/The-Chapel-Cabin-At-Twin-Bridges-Campground.h76659920.Hotel-Information) Glenallen [](https://www.expedia.ca/The-Chapel-Cabin-At-Twin-Bridges-Campground.h76659920.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/10259602.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/dc88ded9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/9dd5e5a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/8df6c129.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bullwinkles Rustic Lodge [](https://www.expedia.ca/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information) Poplar Bluff 8.4/10 Very good (212) "Had to " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda [](https://www.expedia.ca/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/90000000/89720000/89711400/89711320/9da4f272.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/90000000/89720000/89711400/89711320/173f6de2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/90000000/89720000/89711400/89711320/be7997a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi](https://images.trvl-media.com/lodging/90000000/89720000/89711400/89711320/01d1c97c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private lake, beach & hot tub, romantic getaway or family vaca [](https://www.expedia.ca/Wappapello-Hotels-Private-Lake.h89711320.Hotel-Information) Wappapello 9.8/10 Exceptional (37) "A great small clean cabin with a relaxing and quiet view over a body of water. Close to Lake Wappapella and restaurants, our favorite was Don &MJ’s Bar and Lounge. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dwain H. [](https://www.expedia.ca/Wappapello-Hotels-Private-Lake.h89711320.Hotel-Information) ![Smart TV, foosball, books, stereo](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/3a131419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/51ec660e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, foosball, books, stereo](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/aa62026f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/e6fdb43d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Camp Minnow Beach House [](https://www.expedia.ca/Wappapello-Hotels-Camp-Minnow-Beach-House.h96471085.Hotel-Information) Wappapello 9.4/10 Exceptional (16) "Clean and cozy. Very quiet and close to everywhere we wanted to go. Would absolutely stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Conlee P. [](https://www.expedia.ca/Wappapello-Hotels-Camp-Minnow-Beach-House.h96471085.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/24000000/23400000/23393400/23393379/9c3e58b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/24000000/23400000/23393400/23393379/1698d429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player](https://images.trvl-media.com/lodging/24000000/23400000/23393400/23393379/5c2ebb8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/24000000/23400000/23393400/23393379/b8dea1e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 1/4 Mile To The Boat Launch & Beach 2 miles the Camp! Free WiFi, beautiful space [](https://www.expedia.ca/Wappapello-Hotels-14-Mile-To-The-Boat-Launch-Beach-2-Miles-The-Camp-Free-WiFi.h23393379.Hotel-Information) Wappapello 9.2/10 Wonderful (56) "The cabin was perfect for us and a quick weekend away. It was clean and the bed was very comfortable. Being so close to a nice and quiet beach was great. Janet was very responsive and helpful. Great find! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kate B. [](https://www.expedia.ca/Wappapello-Hotels-14-Mile-To-The-Boat-Launch-Beach-2-Miles-The-Camp-Free-WiFi.h23393379.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-28&endDate=2025-12-29®ionId=553248634983343452&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels-Independent.0-0-d553248634983343452--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels-Independent.0-0-d553248634983343452--bIndependent.Travel-Guide-Filter-Hotels) ## Top Puxico Hotel Reviews ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg) ### Drury Inn & Suites Poplar Bluff 10/10 Excellent "The room was Great!" [](https://expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Room was clean and nice. No problems, staff was very nice and professional" [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Holiday Inn Poplar Bluff by IHG](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7_y.jpg) ### Holiday Inn Poplar Bluff by IHG 10/10 Excellent "Clean and very well kept." [](https://expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg) ### Fairfield Inn & Suites by Marriott Poplar Bluff 10/10 Excellent "Clean, friendly.. not to expensive " [](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Travelodge by Wyndham Dexter](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86_y.jpg) ### Travelodge by Wyndham Dexter 10/10 Excellent "Very clean and comfortable hotel. We were pleasantly pleased and had no issue except our tv remote didn’t work but front desk provided another one that worked. I would stay here again and enjoyed breakfast at the train diner next door. Highly recommend hotel and diner to anyone traveling to Dexter. " [](https://expedia.ca/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information) ![Hampton Inn Poplar Bluff](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d_y.jpg) ### Hampton Inn Poplar Bluff 10/10 Excellent "Every single time I come to this location, it always exceeds my expectations. It's always clean.They always have hot coffee and they are super friendly!! Never have anything bad to say about them" [](https://expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/de7e2348_y.jpg) ### Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided 10/10 Excellent "This place is amazing! We've stayed at a lot of different VRBOs and this is by far one of the best! Thanks for having us and we'll definitely be back" [](https://expedia.ca/Secluded-In-The-Woods.h89701234.Hotel-Information) ![Hampton Inn By Hilton Dexter](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/w3836h2556x4y4-c3d811b2_y.jpg) ### Hampton Inn By Hilton Dexter 10/10 Excellent "Staff was helpful and professional. The rooms were clean and comfortable " [](https://expedia.ca/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) ![EC Reed's Mercantile and Hotel](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/fc288d3b_y.jpg) ### EC Reed's Mercantile and Hotel 10/10 Excellent "Cute room, great food, fun soda fountain and friendly owners! Will return! " [](https://expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Advance ](https://www.expedia.ca/Advance-Bed-And-Breakfast.d553248634983475122-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Advance ](https://www.expedia.ca/Advance-Hotels-Cheap-Hotels.0-0-d553248634983475122-tCheapHotels.Travel-Guide-Filter-Hotels) - [Advance Hotels ](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels) - [Lodges in Advance ](https://www.expedia.ca/Advance-Lodges.d553248634983475122-aaLodges.Travel-Guide-Accommodation) - [Motels in Advance ](https://www.expedia.ca/Advance-Motels.d553248634983475122-aaMotels.Travel-Guide-Accommodation) - [Apartments in Baker ](https://www.expedia.ca/Baker-Apartments.d553248634983252914-aaApartments.Travel-Guide-Accommodation) - [Apartments in Bell City ](https://www.expedia.ca/Bell-City-Apartments.d553248634983588961-aaApartments.Travel-Guide-Accommodation) - 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