Title: Hotels by Independent in Puxico from CA $95 | Expedia.ca [Puxico Travel Guide](https://expedia.ca/Puxico.dx553248634983343452)[Hotels in Puxico](https://expedia.ca/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[Vacation Rentals in Puxico](https://expedia.ca/Puxico-Vacation-Rentals.d553248634983343452.Travel-Guide-VacationRentals)[Flights to Puxico](https://expedia.ca/Cheap-Flights-To-Puxico.d553248634983343452.Travel-Guide-Flights)[Puxico Car Rentals](https://expedia.ca/Car-Rentals-In-Puxico.d553248634983343452.Car-Rental-Guide)[Puxico Vacation Packages](https://expedia.ca/Puxico.d553248634983343452.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Puxico from CA $95 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-10-14&endDate=2025-10-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248634983343452&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Puxico Independent Hotels ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/4768517d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/9a624d3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/3f1c7b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/8fbe165c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dexter Inn Dexter 6.8/10 (325) "Been a good stay every night" CA $84 CA $95 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) ![Fountain](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/9c3ffe6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/dc88ded9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin | Living area](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/6b9600b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin | Private kitchen](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/e045844c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bullwinkles Rustic Lodge Poplar Bluff 8.6/10 Excellent (206) "Great stay highly recommend " [](https://www.expedia.ca/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information) ![Deluxe Double Room](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/fc288d3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/a0829ae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/5f50a8a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/145de6a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EC Reed's Mercantile and Hotel Marble Hill 9.6/10 Exceptional (79) "Quiet small town vibe, great food and service! Definitely recommend " CA $147 CA $160 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) ![Smart TV, fireplace, stereo](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/65f4c520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/1c277e81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/w1024h679x0y4-cc4e16cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/de8fdc64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dexter Homestead. Very Cozy & NEW Remodel ! Dexter 8.0/10 Very good (26) "What a relaxing stay! Nicely decorated house, plenty of space, and we appreciated the covered parking. " CA $125 CA $270 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Dexter-Hotels-Dexter-Homestead-Very-Cozy-NEW-Remodel.h63162828.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/116000000/115660000/115656000/115655964/3255fa08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/116000000/115660000/115656000/115655964/f9d287e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115660000/115656000/115655964/5baccb36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/116000000/115660000/115656000/115655964/1ee19172.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Camp Stonebass-Lake House-Hottub Wappapello 10/10 Exceptional (3) "We really enjoyed our time at the house." [](https://www.expedia.ca/Wappapello-Hotels-Camp-Stonebass-Lake-House-Hottub.h115655964.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/de7e2348.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/71aa8e7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/7b7b54ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89710000/89701300/89701234/10599a29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided Greenville 10/10 Exceptional (4) "Cute, cozy, private getaway that you won't want to leave!" CA $237 CA $363 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/Secluded-In-The-Woods.h89701234.Hotel-Information) ![Game room](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/e0d65453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/8f9760a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, foosball, books, stereo](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/aa62026f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sun loungers](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/1f0a7cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Camp Minnow Beach House Wappapello 9.2/10 Wonderful (15) "It was perfect for what we needed!" [](https://www.expedia.ca/Wappapello-Hotels-Camp-Minnow-Beach-House.h96471085.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/46000000/45700000/45699600/45699522/27bd8005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45700000/45699600/45699522/559f44f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45700000/45699600/45699522/cfca3ead.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/46000000/45700000/45699600/45699522/ac053f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home Sweet Home, Spacious Sunroom & Fun Deck! Poplar Bluff 10/10 Exceptional (66) "Excellent venue for our family reunion and very easy to work with hostess. " [](https://www.expedia.ca/Poplar-Bluff-Hotels-Vrbo-Property.h45699522.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/118000000/117060000/117056200/117056200/c7e6c015.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/118000000/117060000/117056200/117056200/310bfb93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/118000000/117060000/117056200/117056200/c7d15671.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/118000000/117060000/117056200/117056200/a15b13b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp Wappapello 9.6/10 Exceptional (4) "Great place and wonderful experience. Tom the owner was second to none. He was always available for any questions and recommendations for places to eat and visit. Definitely highly recommend." [](https://www.expedia.ca/Wappapello-Hotels-Lake-Wappapello-2-Bedroom-Home-18-Mile-To-Beach-And-Boat-Ramp.h117056200.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/2f71029b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/7796e72a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/887417dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76660000/76660000/76659920/b5fb4428.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Chapel Cabin at Twin Bridges Campground Glenallen [](https://www.expedia.ca/The-Chapel-Cabin-At-Twin-Bridges-Campground.h76659920.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=553248634983343452&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels-Independent.0-0-d553248634983343452--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels-Independent.0-0-d553248634983343452--bIndependent.Travel-Guide-Filter-Hotels) ## Top Puxico Hotel Reviews ![Holiday Inn Poplar Bluff by IHG](//images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7_y.jpg) ### Holiday Inn Poplar Bluff by IHG 10/10 Excellent "very" [](https://expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Private lake, beach & hot tub, romantic getaway or family vaca](//images.trvl-media.com/lodging/90000000/89720000/89711400/89711320/c3950ef0_y.jpg) ### Private lake, beach & hot tub, romantic getaway or family vaca 10/10 Excellent "Everything was just right, clean, comfortable, night porch, hot tub was a bonus. Nice quiet neighborhood close to restaurants. I would recommend new glass dishes, and pots/pans. Overall very nice place to stay." [](https://expedia.ca/Wappapello-Hotels-Private-Lake.h89711320.Hotel-Information) ![Motel 6 Poplar Bluff, MO](//images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Property was very clean, staff wa very friendly. And room was perfect!" [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Drury Inn & Suites Poplar Bluff](//images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg) ### Drury Inn & Suites Poplar Bluff 10/10 Excellent "Dining options were excellent " [](https://expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](//images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg) ### Fairfield Inn & Suites by Marriott Poplar Bluff 10/10 Excellent "Nice room" [](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Hampton Inn Poplar Bluff](//images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d_y.jpg) ### Hampton Inn Poplar Bluff 10/10 Excellent "Clean room and friendly staff." [](https://expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Lake Wappapello](//images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32_y.jpg) ### Lake Wappapello 10/10 Excellent "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." [](https://expedia.ca/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) ![OYO Hickory House Inn](//images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/012f90a1_y.jpg) ### OYO Hickory House Inn 10/10 Excellent "Nice room very comfortable bed's" [](https://expedia.ca/Sikeston-Hotels-Hickory-House-Inn.h1152272.Hotel-Information) ![Dexter Inn](//images.trvl-media.com/lodging/1000000/860000/856200/856148/4768517d_y.jpg) ### Dexter Inn 10/10 Excellent "Been a good stay every night" [](https://expedia.ca/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Advance](https://www.expedia.ca/Advance-Bed-And-Breakfast.d553248634983475122-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Advance](https://www.expedia.ca/Advance-Hotels-Cheap-Hotels.0-0-d553248634983475122-tCheapHotels.Travel-Guide-Filter-Hotels) - [Advance Hotels](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels) - 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