Book The Best Hotels in Prairie Home, MO for 2026 from CA $85 - Fully Refundable Options

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Our top choices for Prairie Home hotels

A multi-story hotel with a parking lot in front.

A gym with a treadmill, exercise bike, and weight machine.

A hotel room with two beds, a nightstand, a lamp, and a patterned carpet.

A dining area with tables and chairs, a kitchen in the background, and a patterned carpet.

1. Baymont by Wyndham Columbia, MO

Columbia

Susan

CA $85

CA $96 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a dining area, a sofa, a TV, and a view of the city.

A hotel room with a large bed, two bedside tables with lamps, a desk with a computer, and a large window offering a view of the city.

A banquet hall with round tables set for a formal event, featuring a patterned carpet and a high ceiling with chandeliers.

A Wyndham hotel with a prominent illuminated sign, a covered entrance, and a parking area.

2. Wyndham Executive Center Columbia

Columbia

Shara

CA $141

CA $160 total

includes taxes & fees

Oct 30 - Oct 31

A front-loading washing machine with a Speed Queen commercial dryer, a guest laundry sign, and a metal towel rack.

A hotel lobby with a reception desk, a framed welcome sign, and a large window with curtains.

A hotel room with a bed, a sofa, a television, and a large window with curtains.

A hotel room with a bed, two bedside tables, a window with curtains, a wall-mounted air conditioner, and a large picture of a boat on the wall.

3. Super 8 by Wyndham Boonville

Boonville

"Staff was very friendly and helpful. I was working nights on the highway and needed to find a place that would allow me to check in at 5:00am and after calling multiple hotels this was the only that would accommodate me. The room was clean and slightly updated. Only complaint was the bed frame was all metal and made a lot of noise when moving around on the bed. Overall I would stay here again."

John

CA $102

CA $116 total

includes taxes & fees

Oct 18 - Oct 19

A casino with multiple gaming machines, an ATM, and a staircase leading to upper levels.

An outdoor patio with a fire feature, seating, and hanging flower baskets.

A spacious lobby with a patterned carpet, multiple seating areas including sofas and chairs, and a large chandelier.

A large casino with numerous slot machines and a variety of gaming tables.

4. Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

Boonville

Janeice

CA $97

CA $129 total

includes taxes & fees

Nov 10 - Nov 11

An indoor swimming pool with lounge chairs and a hot tub, surrounded by wooden walls and windows.

A hotel lobby with a sofa, chairs, a table, and a patterned carpet.

A hotel with an indoor pool, featuring a prominent sign and a brick facade.

A hotel room with a desk, computer, and a sofa. There is a dining area in the background with chairs and tables.

5. Quality Inn & Suites Boonville - Columbia

Boonville

Derek

CA $143

CA $163 total

includes taxes & fees

Nov 9 - Nov 10

A modern office space with a meeting area featuring a large table and chairs, a purple accent wall, and a view through large windows.

A modern office space with a desk area, seating, and a hanging chair.

6. Tru By Hilton Columbia South

Columbia

Kevin M.

CA $127

CA $145 total

includes taxes & fees

Oct 25 - Oct 26

A modern lobby with a sectional sofa, a flat-screen TV, and a glass wall offering a view of the city.

A hotel room with a large bed, a sofa, a desk, and a television.

An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and tables.

A gym with treadmills, elliptical machines, and a bench.

7. Drury Inn & Suites Columbia Stadium Boulevard

Columbia

SHERILYN

CA $143

CA $161 total

includes taxes & fees

Oct 18 - Oct 19

A swimming pool area with a covered bench, a chair, and a sign indicating pool rules.

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a wardrobe.

A hotel room with a desk, two chairs, a printer, a phone, a framed picture, and a 'No Smoking' sign.

A modern room with a blue wall, a gray sofa, a wooden coffee table, and a yellow chair.

8. Holiday Inn Express Boonville by IHG

Boonville

Thomas

CA $181

CA $234 total

includes taxes & fees

Nov 8 - Nov 9

A lobby with a reception desk, two sofas, a coffee table, and a patterned rug.

An indoor swimming pool with clear water, surrounded by white walls and a tiled floor.

A modern restaurant with high tables and booths, large windows, and a patterned carpet.

A hotel room with a large bed, a desk with a flat-screen TV, a chair, a desk lamp, and a nightstand with a lamp.

9. Wingate by Wyndham - Columbia

Columbia

Carlos

CA $123

CA $139 total

includes taxes & fees

Oct 18 - Oct 19

A spacious living area with a blue sofa, leather armchairs, and a flat-screen TV mounted on a wooden cabinet. Large windows provide a view of parked cars outside.

A hotel room with a large bed, a desk, a chair, a lamp, and a window with curtains.

A restaurant with multiple tables and chairs, a counter with a coffee machine, and a menu board.

A hotel room with a large flat-screen TV, two beds, a sofa, and a desk.

10. Comfort Suites Columbia - University Area

Columbia

Lisa

CA $140

CA $158 total

includes taxes & fees

Nov 1 - Nov 2

A modern living room with grey sofas, a coffee table, and a fireplace. There are framed pictures on the wall and a floor lamp.

A hotel room with a large bed, a desk with a lamp, a kitchenette, and a bathroom.

A modern restaurant with blue cabinets, wooden tables and chairs, and a kitchen area with appliances.

A reception desk with a wooden finish, three pendant lights, framed artwork on the wall, and a small display case with pastries.

11. Country Inn & Suites by Radisson, Columbia, MO

Columbia

Susan

CA $120

CA $136 total

includes taxes & fees

Nov 1 - Nov 2

A patio area with a fire pit, outdoor seating, and a grill.

A modern building with a 'park' sign, stone facade, and outdoor seating area.

A rooftop pool with lounge chairs and umbrellas, surrounded by a brick building with large windows.

A modern dining area with a long wooden table, multiple chairs, a flat-screen TV mounted on a stone wall, and a fireplace.

12. TownePlace Suites by Marriott Columbia

Columbia

Barb

CA $168

CA $192 total

includes taxes & fees

Nov 1 - Nov 2

A modern interior with round tables and chairs, a bar area, and a large window offering a view of the outside.

A patio area with outdoor seating, a pool, and a stone building facade.

A modern lounge area with a sofa, round tables, and chairs, a kitchen area, and large windows.

A multi-story hotel with a covered entrance and a stone facade.

13. Best Western Plus Columbia Inn

Columbia

Shawn

CA $117

CA $132 total

includes taxes & fees

Oct 25 - Oct 26

14. Hotel Frederick

Boonville

natalie

CA $162

CA $184 total

includes taxes & fees

Nov 3 - Nov 4

A covered outdoor seating area with wooden beams and a lantern, overlooking a brick building and greenery.

A hotel room with a bed, a chair, a floor lamp, and a painting on the wall.

A modern gym with treadmills, weight machines, and free weights.

A formal dining table set with crystal glassware, plates, and napkins, with a decorative crystal centerpiece.

15. Courtyard by Marriott Columbia Missouri

Columbia

Jeremy

CA $162

CA $183 total

includes taxes & fees

Oct 18 - Oct 19

A hotel lobby with a reception desk, a coffee machine, a small table with a lamp, and framed artwork on the walls.

A long, narrow hallway with patterned carpet, wooden doors on both sides, and a bright exit sign at the end.

A hotel room with two beds, each with a patterned quilt, a nightstand, and a wall-mounted lamp.

16. Midway Budget Inn

Columbia

Brian

CA $123

CA $130 total

includes taxes & fees

Oct 12 - Oct 13

A spacious bar area with high tables and chairs, a large flat-screen TV mounted on the wall, and a bar stocked with bottles.

A modern bar area with a long counter, bar stools, and a fireplace.

An indoor swimming pool with a tiled floor, a glass barrier, and a lifeguard chair.

A hotel room with a sofa, a green ottoman, a desk with a lamp, and a framed cityscape picture on the wall.

17. Drury Plaza Hotel Columbia East

Columbia

Kevin

CA $145

CA $164 total

includes taxes & fees

Oct 18 - Oct 19

An indoor swimming pool with clear signage indicating no lifeguard on duty and no diving.

A reception desk with a wooden finish and granite counter, a framed welcome sign, and a lamp.

A hotel room with a bed, a bathroom with a bathtub, a bedside table with a lamp, and a thermostat on the wall.

A Hampton Inn & Suites hotel with a brick facade, a covered entrance, and a parking lot.

18. Hampton Inn & Suites Columbia at University

Columbia

Jamie

CA $151

CA $171 total

includes taxes & fees

Oct 18 - Oct 19

A large dining area with wooden tables and chairs, a kitchen area with a trash bin, and a television on the wall.

A log cabin interior with a stone fireplace, leather sofa, and a large painting of cowboys.

An indoor swimming pool with wooden beams, stone walls, and artificial trees.

A log cabin-style room with a bed, a fireplace, a stone wall, a TV, and a large window.

19. Stoney Creek Hotel Columbia

Columbia

Brett

CA $153

CA $173 total

includes taxes & fees

Oct 18 - Oct 19

A hotel entrance with a covered walkway, a brick facade, and a well-lit exterior.

A large indoor swimming pool with multiple lanes, surrounded by lounge chairs and tables.

A hotel room with two desks, each with a laptop and a chair, and a small cabinet.

A buffet with labeled containers of omelets and other food items.

20. Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

Columbia

Jennifer

CA $163

CA $184 total

includes taxes & fees

Nov 1 - Nov 2

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Top Prairie Home Hotel Reviews

Hotel Blu

10/10 Excellent

"It was hard to find, due to us looking for hotel blu, and not a hotel 6 ( the sign had not changed. But overall it was clean, and quiet."

Wingate by Wyndham - Columbia

10/10 Excellent

"Very clean and helpful staff !"

Ramada by Wyndham Columbia

8/10 Good

"Worth the price - room was very clean and updated - the hotel itself is dated and the side door was a bit clunky to get into"

Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

10/10 Excellent

"Everything was excellent. Would definitely recommend"

Drury Plaza Hotel Columbia East

10/10 Excellent

"Great stay at Drury Hotels. Thought the food and drinks in the early evening was a nice touch. Breakfast was also good. Pet friendly. Would recommend."

Holiday Inn Columbia East by IHG

8/10 Good

"The hotel itself was nice but our bathroom appeared to have some old water damage that was not well repaired"

Red Roof Inn Columbia, MO

8/10 Good

"They were good listeners so not a good first impression but got better"

More cheap stays in Prairie Home

Hotel Blu

3402 Interstate 70 Dr SE Columbia MO

CA $75

CA $85 total

Oct 19 - Oct 20

includes taxes & fees

6.6/10 (246 reviews)

Baymont by Wyndham Columbia, MO

2500 I 70 Dr Sw Columbia MO

CA $85

CA $96 total

Oct 18 - Oct 19

includes taxes & fees

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

CA $90

CA $102 total

Oct 18 - Oct 19

includes taxes & fees

7.4/10 Good! (1,004 reviews)

Best Western Plus Columbia Inn

2904 Clark Lane Columbia MO

CA $117

CA $132 total

Oct 25 - Oct 26

includes taxes & fees

Country Inn & Suites by Radisson, Columbia, MO

817 N Keene St Columbia MO

CA $120

CA $136 total

Nov 1 - Nov 2

includes taxes & fees

Stoney Creek Hotel Columbia

2601 S Providence Rd Columbia MO

CA $153

CA $173 total

Oct 18 - Oct 19

includes taxes & fees

Hotels in Prairie Home with star rating

Frequently asked questions

What's the best place for a stay in Prairie Home?

Located 15.7 mi (25.3 km) from the heart of Prairie Home, Baymont by Wyndham Columbia, MO is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Drury Plaza Hotel Columbia East and Stoney Creek Hotel Columbia. See all available top hotels, or vacation rentals in Prairie Home.

What's the top vacation rental that Prairie Home has to offer?

The Stone & Bridge: Close to MKT Trail & Dog Park, Dining, Groceries & I-70: This vacation home rental near Prairie Home offers a patio, a barbecue grill, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in Prairie Home.

If I need to cancel my hotel reservation in Prairie Home, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Prairie Home.

What's it like staying in Prairie Home?

Those traveling to Prairie Home are sure to enjoy the sights to see and things to do. There are 237 hotels and other accommodations in the surrounding area. Find out more about Prairie Home.

What should I do while I'm visiting Prairie Home?

Places to visit in the wider area include Warm Springs Ranch, Isle of Capri Casino, and Rock Bridge Memorial State Park. You'll also find Shelter Gardens and Columbia Mall in the area. Check out what more to see and do in Expedia's Prairie Home guide.

What's the seasonal weather like in Prairie Home?

The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 36°F. Average annual precipitation for Prairie Home is 43 inches.

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Find hotels in Prairie Home, MO from CA $85

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Prairie Home

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Prairie Home hotels

1. Baymont by Wyndham Columbia, MO

2. Wyndham Executive Center Columbia

3. Super 8 by Wyndham Boonville

4. Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

5. Quality Inn & Suites Boonville - Columbia

6. Tru By Hilton Columbia South

7. Drury Inn & Suites Columbia Stadium Boulevard

8. Holiday Inn Express Boonville by IHG

9. Wingate by Wyndham - Columbia

10. Comfort Suites Columbia - University Area

11. Country Inn & Suites by Radisson, Columbia, MO

12. TownePlace Suites by Marriott Columbia

13. Best Western Plus Columbia Inn

14. Hotel Frederick

15. Courtyard by Marriott Columbia Missouri

16. Midway Budget Inn

17. Drury Plaza Hotel Columbia East

18. Hampton Inn & Suites Columbia at University

19. Stoney Creek Hotel Columbia

20. Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

Top Prairie Home Hotel Reviews

Hotel Blu

Wingate by Wyndham - Columbia

Ramada by Wyndham Columbia

Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

Drury Plaza Hotel Columbia East

Holiday Inn Columbia East by IHG

Red Roof Inn Columbia, MO

More cheap stays in Prairie Home

Hotel Blu

Baymont by Wyndham Columbia, MO

Ramada by Wyndham Columbia

Best Western Plus Columbia Inn

Country Inn & Suites by Radisson, Columbia, MO

Stoney Creek Hotel Columbia

Hotels in Prairie Home with star rating

Frequently asked questions

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