Title: Book the Best Portsmouth LUXURY Hotels - Upscale Hotels in Portsmouth, OH | Expedia.ca [Hotels in Portsmouth](https://expedia.ca/Portsmouth-Hotels.d6059579.Travel-Guide-Hotels)[Vacation Rentals in Portsmouth](https://expedia.ca/Portsmouth-Vacation-Rentals.d6059579.Travel-Guide-VacationRentals)[Flights to Portsmouth](https://expedia.ca/Cheap-Flights-To-Portsmouth.d6059579.Travel-Guide-Flights)[Portsmouth Car Rentals](https://expedia.ca/Car-Rentals-In-Portsmouth.d6059579.Car-Rental-Guide)[Portsmouth Vacation Packages](https://expedia.ca/Portsmouth.d6059579.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/d2eef9309a9008e0f17804ac94e4cfa9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Tyler Estle # Find luxury hotels in Portsmouth, OH ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Portsmouth Luxury Hotels Tonight [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=6059579&startDate=2025-09-28&endDate=2025-09-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=6059579&startDate=2025-09-29&endDate=2025-09-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6059579&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6059579&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Portsmouth Luxury Hotels ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/27200/27143/74dfb1af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/27200/27143/b9331027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27200/27143/w2880h2595x0y12-728a117f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/30000/27200/27143/77d5469d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Wheelersburg Wheelersburg 7.0/10 Good (282) "Staff was extremely nice." CA $113 CA $126 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Portsmouth-Hotels-Red-Roof-Inn-Portsmouth-Wheelersburg.h27143.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-12&endDate=2025-10-13®ionId=6059579&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Portsmouth Hotel Reviews ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in Portsmouth? > Let Expedia help you arrange your flight to Huntington, WV (HTS-Tri-State) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Portsmouth has to offer. During your visit, you might want to enjoy the university which Portsmouth is known for. ### When can I expect good weather in Portsmouth? > Planning for the weather is a good way to make your trip to Portsmouth relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Portsmouth is 52 inches. ### What's there to see and do in Portsmouth? > Experience all that Portsmouth has to offer when you visit Ohio River, Portsmouth Floodwall Mural, and Boneyfiddle Commercial District. 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