Title: Poplar Bluff Regional Medical Center in Poplar Bluff - Tours and Activities | Expedia.ca [Poplar Bluff Regional Medical Center Hotels](https://expedia.ca/Poplar-Bluff-Regional-Medical-Center-Hotels.0-l624552311360655360-0.Travel-Guide-Filter-Hotels)[Flights to Poplar Bluff](https://expedia.ca/Cheap-Flights-To-Poplar-Bluff.d9449.Travel-Guide-Flights)[Poplar Bluff Regional Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Poplar-Bluff-Regional-Medical-Center.d624552311360655360.Car-Rental-Guide)[Poplar Bluff Vacation Packages](https://expedia.ca/Poplar-Bluff.d9449.Destination-Travel-Guides) # Poplar Bluff Regional Medical Center Tours and Activities ## Visit Poplar Bluff Regional Medical Center Activities [Poplar Bluff travel guide](https://expedia.ca/Poplar-Bluff.dx9449) --- --- ## Plan a trip to see Poplar Bluff Regional Medical Center Price found within the past 48 hours. Click for updated prices. ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Drury Inn & Suites Cape Girardeau CA $2,704 per person Apr 6 - Apr 11 found 21 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Cape Girardeau (CGI) 9.4/10 Exceptional! (1,000 reviews) The room was great and the staff was friendly as always. Reviewed on Feb 26, 2026 ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Drury Plaza Hotel Cape Girardeau Conference Center CA $2,748 per person Apr 6 - Apr 11 found 21 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Cape Girardeau (CGI) 9.6/10 Exceptional! (1,003 reviews) Very helpful staff. Excellent facility Reviewed on Feb 25, 2026 ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG CA $2,736 per person Apr 6 - Apr 11 found 21 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Cape Girardeau (CGI) 9.4/10 Exceptional! (1,001 reviews) Would have been a 5 rating except for the noisy heating system. Reviewed on Feb 2, 2026 ### Popular places to visit ![Breathtaking view at the dam by the road and some small trails for walking as well!](https://images.trvl-media.com/place/635033036780072960/d91a319c-d0dc-4302-9360-97af4b36e4b3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Lake Wappapello State Park You can take time to visit Lake Wappapello State Park during your travels to Wappapello. [](https://expedia.ca/Lake-Wappapello-State-Park-Wappapello.d635033036780072960.Vacation-Attraction) ![Sunrise from the duck blind. ](https://images.trvl-media.com/place/183505/9493e565-66da-46c4-8222-30a8f5da22bb.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Lake Wappapello Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/Lake-Wappapello-Wappapello.d553248621532648460.Vacation-Attraction) #### North Main Street Historic District You can find out about the history of Poplar Bluff with a trip to North Main Street Historic District. While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/North-Main-Street-Historic-District-Poplar-Bluff.d951219743330058240.Vacation-Attraction) #### Margaret Harwell Art Museum You can study the exhibits at Margaret Harwell Art Museum, a museum with a storied past, during your travels to Poplar Bluff. Stroll along the riverfront or experience the entertainment venues in this family-friendly area. [](https://expedia.ca/Margaret-Harwell-Art-Museum-Poplar-Bluff.d553248621554123003.Vacation-Attraction) #### Black River Coliseum Catch an event at Black River Coliseum during your trip to Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/Black-River-Coliseum-Poplar-Bluff.d553248635997959425.Vacation-Attraction) #### Mo-Ark Regional Railroad Museum You can study the exhibits at Mo-Ark Regional Railroad Museum, a museum with a storied past, during your travels to Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/Mo-Ark-Regional-Railroad-Museum-Poplar-Bluff.d553248621554123004.Vacation-Attraction) --- ## Best Lodging Options Near Poplar Bluff Regional Medical Center ## Check availability on hotels close to Poplar Bluff Regional Medical Center [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624552311360655360&startDate=2026-02-27&endDate=2026-02-28)[Feb 27 - Feb 28](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624552311360655360&startDate=2026-02-27&endDate=2026-02-28) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624552311360655360&startDate=2026-02-28&endDate=2026-03-01)[Feb 28 - Mar 1](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624552311360655360&startDate=2026-02-28&endDate=2026-03-01) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624552311360655360&startDate=27%2F02%2F2026&endDate=01%2F03%2F2026)[Feb 27 - Mar 1](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=624552311360655360&startDate=27%2F02%2F2026&endDate=01%2F03%2F2026) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Poplar Bluff 2220 N Westwood Blvd Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott Poplar Bluff 3109 Oak Grove Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Hampton Inn Poplar Bluff](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Poplar Bluff 2420 Crestwood Dr Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Holiday Inn Poplar Bluff by IHG](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Poplar Bluff by IHG 2781 N Westwood Blvd Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Super 8 by Wyndham Poplar Bluff Missouri](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/29f9134c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Super 8 by Wyndham Poplar Bluff Missouri 2831 N Westwood Blvd Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information) ![Comfort Inn Poplar Bluff North](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/1db8fd06_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn Poplar Bluff North 2582 N Westwood Blvd Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information) ![Home Sweet Home, Spacious Sunroom & Fun Deck!](https://images.trvl-media.com/lodging/46000000/45700000/45699600/45699522/27bd8005_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Home Sweet Home, Spacious Sunroom & Fun Deck! Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Vrbo-Property.h45699522.Hotel-Information) ![Villa 5 · Poplar Bluff 2BR/1.5 Bath House (2022 Renovation)](https://images.trvl-media.com/lodging/85000000/84080000/84071500/84071494/878731c0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Villa 5 · Poplar Bluff 2BR/1.5 Bath House (2022 Renovation) Poplar Bluff MO [](https://expedia.ca/Poplar-Bluff-Hotels-Villa-5-Poplar-Bluff-2BR15-Bath-House.h84071494.Hotel-Information) [See all 79 properties in Poplar Bluff Regional Medical Center](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=624552311360655360) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. 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