Pike County Vacation Rentals

Compare and save

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Aug 15 - Aug 17
In two weeks
Aug 22 - Aug 24
In one month
Sep 5 - Sep 7
In two months
Oct 3 - Oct 5

Featured Vacation Homes in Pike County

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Interior

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

9.8 out of 10, Exceptional, (7)
"Family really enjoyed our stay at this unique location. Very spacious and clean. Would definitely recommend or stay again no question"
The price is CA $180
CA $269 total
includes taxes & fees
Aug 12 - Aug 13
Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Peaceful, Country Cottage with Open Floor Plan
Dining

Peaceful, Country Cottage with Open Floor Plan

10.0 out of 10, Exceptional, (200)
"This was a very beautiful peaceful, lovable three bedroom home very clean very neat very tidy very good landscaping. It was wonderful. My kids loved it and I loved it. I would love to stay here again during the next tournament. Thank you for having a beautiful place for us to stay"
The price is CA $179
CA $340 total
includes taxes & fees
Aug 7 - Aug 8
Peaceful, Country Cottage with Open Floor Plan
Centrally Located near MarkTwain Caves, Downtown, Nature Trails, Winery 5mins
Exterior

Centrally Located near MarkTwain Caves, Downtown, Nature Trails, Winery 5mins

6.0 out of 10, (4)
"Great town. Great place. Great host. Great vacation. "
The price is CA $185
CA $284 total
includes taxes & fees
Aug 16 - Aug 17
Centrally Located near MarkTwain Caves, Downtown, Nature Trails, Winery 5mins
The Indigo House- Located in the heart of Historic Hannibal, Missouri
Interior

The Indigo House- Located in the heart of Historic Hannibal, Missouri

10.0 out of 10, Exceptional, (39)
"Very clean, beautiful, had everything we needed and more. "
The price is CA $248
CA $496 total
includes taxes & fees
Aug 10 - Aug 11
The Indigo House- Located in the heart of Historic Hannibal, Missouri
“Peaceful Retreat” @ MTL
Property grounds

“Peaceful Retreat” @ MTL

10.0 out of 10, Exceptional, (101)
"We have stayed at this house many times because it is a lovely location. The patio and gazebo are our favorite! The owners are the nicest people!"
“Peaceful Retreat” @ MTL
Charming 3BR/2BA home—peaceful country vibes, perfect for relaxing stays!
Interior

Charming 3BR/2BA home—peaceful country vibes, perfect for relaxing stays!

6.8 out of 10, (3)
"The house was great and Nicole was a great host. "
Charming 3BR/2BA home—peaceful country vibes, perfect for relaxing stays!
Cozy 3 bed, 2 bath home close to historic downtown Hannibal
Fridge, microwave, oven, stovetop

Cozy 3 bed, 2 bath home close to historic downtown Hannibal

10.0 out of 10, Exceptional, (39)
"it was very clean, well stocked and so cozy...the host was very accessible and so kind..would certainly stay here again if we are back in the area"
Cozy 3 bed, 2 bath home close to historic downtown Hannibal
Historic Main Street Cottage
Property grounds

Historic Main Street Cottage

10.0 out of 10, Exceptional, (30)
"The house was great! There was plenty of space for all of us, and we can't wait to come back!"
Historic Main Street Cottage
Relaxing, Quiet get away where you can enjoy the outdoors.
4 bedrooms, free WiFi, bed sheets

Relaxing, Quiet get away where you can enjoy the outdoors.

10.0 out of 10, Exceptional, (27)
"This a second time we have stayed at this property. It is perfect for our family."
Relaxing, Quiet get away where you can enjoy the outdoors.
Newly Built Shouse Near Mark Twain Lake!
Smart TV, fireplace

Newly Built Shouse Near Mark Twain Lake!

10.0 out of 10, Exceptional, (2)
"We had a great stay here! Perfect place for a weekend get away. A quick drive to the marina and having the stocked pond was entertainment for the evening! Great and responsive hosts as well, highly recommend! "
The price is CA $303
CA $409 total
includes taxes & fees
Aug 7 - Aug 8
Newly Built Shouse Near Mark Twain Lake!
Gorgeous Victorian with Seasonal Pool , sleeps 8, pet friendly close to downtown
Exterior

Gorgeous Victorian with Seasonal Pool , sleeps 8, pet friendly close to downtown

10.0 out of 10, Exceptional, (9)
"Enjoyed"
Gorgeous Victorian with Seasonal Pool , sleeps 8, pet friendly close to downtown
A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.
Interior

A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.

10.0 out of 10, Exceptional, (19)
"We enjoyed every minute in this charming home It was very clean and came with everything we needed I will be back Chris was very helpful and quick to respond to all my questions "
A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.
Completely Renovated house 5 Minutes from downtown Hannibal Historic District.
Property grounds

Completely Renovated house 5 Minutes from downtown Hannibal Historic District.

10.0 out of 10, Exceptional, (43)
"My sister and I were looking for a low key week to catch up. Hannibal was a good place to visit. The house had more than enough space. The kitchen was fully equipped, beds were comfy, and the front porch was our favorite place to hang out."
Completely Renovated house 5 Minutes from downtown Hannibal Historic District.
Mark Twain lake getaway at Blue Lagoon!
Property grounds

Mark Twain lake getaway at Blue Lagoon!

10.0 out of 10, Exceptional, (31)
"Not far from Twain lake, this cabin has everything you’ll ever need for a quiet relaxing stay!"
Mark Twain lake getaway at Blue Lagoon!
Charming 2-bedroom house at Mark Twain Lake
Exterior

Charming 2-bedroom house at Mark Twain Lake

9.8 out of 10, Exceptional, (17)
"It was wonderful! The house was perfect! Really enjoyed sitting outside by the fire. Was a very relaxing stay. Would love to stay again!"
Charming 2-bedroom house at Mark Twain Lake
Mark Twain lake getaway.
Terrace/patio

Mark Twain lake getaway.

9.8 out of 10, Exceptional, (28)
"Very happy with our stay, I would highly recommend."
Mark Twain lake getaway.
Admiral Fuqua House - Large downtown Hannibal Home
Property grounds

Admiral Fuqua House - Large downtown Hannibal Home

9.6 out of 10, Exceptional, (38)
"Everything was awesome"
Admiral Fuqua House - Large downtown Hannibal Home
Sweet Retreat at Mark Twain Lake! Historic 4BR/2BA Dog & Family Friendly Home!
Fridge, microwave, oven, stovetop

Sweet Retreat at Mark Twain Lake! Historic 4BR/2BA Dog & Family Friendly Home!

10.0 out of 10, Exceptional, (2)
"Had good time. The kids loved it. They got to play games and even baseball in the extra lot. Being a small town going for a walk in morning was great and local grocery store walkable."
The price is CA $357
CA $592 total
includes taxes & fees
Aug 7 - Aug 8
Sweet Retreat at Mark Twain Lake! Historic 4BR/2BA Dog & Family Friendly Home!
The John Sydney House - Family and Pet Friendly Historic Home Downtown
Exterior

The John Sydney House - Family and Pet Friendly Historic Home Downtown

8.8 out of 10, Excellent, (5)
"The location was perfect and we loved the architecture/woodwork of the home. Lots of space heaters throughout home to keep us warm on a cold weekend. Beds were super comfortable. Nice touch with the coffees and snacks left for us."
The price is CA $227
CA $353 total
includes taxes & fees
Aug 11 - Aug 12
The John Sydney House - Family and Pet Friendly Historic Home Downtown
Amazing Hannibal Home - Eitaly’s on Paris
Smart TV, DVD player

Amazing Hannibal Home - Eitaly’s on Paris

7.0 out of 10, Good, (8)
"It looked a little different than expected,but it was a cute little place and as perfect for our visit. Would recommend the host. He was very friendly and helpful."
Amazing Hannibal Home - Eitaly’s on Paris
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Pike County Hotel Reviews

Quality Inn & Suites Hannibal

Quality Inn & Suites Hannibal

10/10 Excellent
"Hotel was quiet staff friendly"
Daniel 2-night trip
Posted 1 day ago
Quality Inn & Suites Hannibal