Title: Book the Best BUSINESS Hotels in Picayune in 2025 | Expedia.ca [Hotels in Picayune](https://expedia.ca/Picayune-Hotels.d9372.Travel-Guide-Hotels)[Vacation Rentals in Picayune](https://expedia.ca/Picayune-Vacation-Rentals.d9372.Travel-Guide-VacationRentals)[Flights to Picayune](https://expedia.ca/Cheap-Flights-To-Picayune.d9372.Travel-Guide-Flights)[Picayune Car Rentals](https://expedia.ca/Car-Rentals-In-Picayune.d9372.Car-Rental-Guide)[Picayune Vacation Packages](https://expedia.ca/Picayune.d9372.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Picayune, MS from CA $96 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Picayune Business Hotels Tonight [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-10-20&endDate=2025-10-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Oct 21 - Oct 22](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-10-21&endDate=2025-10-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Picayune Business Hotels ![Exterior](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/f291f597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/65070cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/0d0c1424.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/53af01e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Picayune-Stennis Space Center by IHG Picayune 9.0/10 Wonderful (625) "Clean room staff was great air conditioning was super and breakfast was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Haley CA $139 CA $151 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Picayune-Hotels-Holiday-Inn-Express-Picayune-Stennis-Space-Center.h2665063.Hotel-Information) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/521624b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/60c19139.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, towels](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/92ca1b1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/966a4633.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Picayune Picayune 6.6/10 (228) "The property was dated but clean and was a good value for the cost, overall. However, neighbors on both sides of us had a party in the parking lot with LOUD music and laughter until 11 pm 2 of the 3 nights of our stay. The bed was clean but most uncomfortable. We probably will choose another hotel for our next stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melna CA $94 CA $103 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Picayune-Hotels-Super-8-By-Wyndham-Picayune.h1926144.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/e69597e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/a638d545.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/f94cd31a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/e3c21a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Picayune Picayune 6.2/10 (134) "The staff was friendly and it was very quiet. The pool was not open and the room could really use updating." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather CA $98 CA $107 total includes taxes & fees Nov 18 - Nov 19 [](https://www.expedia.ca/Picayune-Hotels-Econo-Lodge-Picayune.h61048.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/a50035f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/5ac349d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/902940fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/f3c44ff0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Slidell I-10 Slidell 7.6/10 Good (224) "Good spot for one night " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Valentina CA $82 CA $96 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/New-Orleans-Hotels-Quality-Inn.h101532511.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/6130fa7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/971ec382.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/a33e6452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/fc4a15b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Slidell Slidell 8.2/10 Very good (623) "Friendly staff and clean room. It is a very old hotel but it’s clean and comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alan CA $96 CA $111 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/New-Orleans-Hotels-Sleep-Inn-Slidell.h526304.Hotel-Information) ![Suite, 2 Queen Beds](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/5afce122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/f5abc0dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/78b260bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/9351deed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Slidell by IHG Slidell 9.4/10 Exceptional (904) "Would recommend as an excellent place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jim CA $135 CA $156 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/New-Orleans-Hotels-Holiday-Inn-Express-Slidell.h9766950.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2470000/2469100/2469031/a3ce71af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/3000000/2470000/2469100/2469031/898c3577.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2470000/2469100/2469031/4b3ec9ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2470000/2469100/2469031/763dd536.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Slidell Slidell 8.6/10 Excellent (935) "Had a soccer tournament in a nearby town, affordable, clean, for a good place to sleep before hitting the fields again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yvette CA $103 CA $120 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/New-Orleans-Hotels-Quality-Inn-Suites.h2469031.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/6000000/5120000/5111100/5111070/0b48f653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/6000000/5120000/5111100/5111070/5488974b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/6000000/5120000/5111100/5111070/98f87390.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5120000/5111100/5111070/99d94b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Mandeville - Covington Mandeville 8.2/10 Very good (826) "Nice affordable place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $120 CA $136 total includes taxes & fees Oct 24 - Oct 25 [](https://www.expedia.ca/Hammond-Hotels-Comfort-Suites-Mandeville.h5111070.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/5844a2ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, down comforters, individually decorated](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/219a048b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/69070001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/9e6b0e67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Slidell 8.8/10 Excellent (1000) "Good stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $124 CA $144 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/New-Orleans-Hotels-Comfort-Inn-Suites.h11266063.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/86740aab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/fd395576.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/5c21d6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/0d77dc8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Silver Slipper Casino & Hotel - Adults Only Bay St Louis 8.6/10 Excellent (1006) "Clean room & friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marilyn CA $111 CA $121 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-03&endDate=2025-11-04®ionId=9372&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Picayune Hotel Reviews ![Homewood Suites Slidell](//images.trvl-media.com/lodging/4000000/3620000/3618300/3618226/w3837h2558x3y3-21c2b95c_y.jpg) ### Homewood Suites Slidell 10/10 Excellent "One of the best hotels we have stayed on our family trips. Clean, great breakfast, attentive staff. " [](https://expedia.ca/New-Orleans-Hotels-Homewood-Suites-Slidell.h3618226.Hotel-Information) ![Ramada by Wyndham Diamondhead I-10/Gulfport](//images.trvl-media.com/lodging/1000000/50000/49900/49812/2531a1ea_y.jpg) ### Ramada by Wyndham Diamondhead I-10/Gulfport 10/10 Excellent "Clean, comfortable rooms and great staff!" [](https://expedia.ca/Biloxi-Hotels-Ramada-By-Wyndham-Diamondhead-I-10Gulfport.h49812.Hotel-Information) ![Holiday Inn Express Picayune-Stennis Space Center by IHG](//images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/f291f597_y.jpg) ### Holiday Inn Express Picayune-Stennis Space Center by IHG 10/10 Excellent "Clean room staff was great air conditioning was super and breakfast was great " [](https://expedia.ca/Picayune-Hotels-Holiday-Inn-Express-Picayune-Stennis-Space-Center.h2665063.Hotel-Information) ![Hollywood Casino Gulf Coast](//images.trvl-media.com/lodging/1000000/530000/526700/526688/d677d4b8_y.jpg) ### Hollywood Casino Gulf Coast 10/10 Excellent "We enjoyed our stay really enjoyed spending time on the new Holly deck ! Beautiful views! The only negative I can say about our stay was that the temperature in the room was not comfortable, but other than that it was perfect ! " [](https://expedia.ca/Biloxi-Hotels-Hollywood-Casino-Gulf-Coast.h526688.Hotel-Information) ![Holiday Inn Covington by IHG](//images.trvl-media.com/lodging/9000000/8380000/8370400/8370311/954b4dc8_y.jpg) ### Holiday Inn Covington by IHG 10/10 Excellent "The anti-slip design in the bathroom is impressive:" [](https://expedia.ca/Hammond-Hotels-Holiday-Inn-Covington.h8370311.Hotel-Information) ![Country Inn & Suites by Radisson, Covington, LA](//images.trvl-media.com/lodging/3000000/2810000/2804100/2804087/54985ef1_y.jpg) ### Country Inn & Suites by Radisson, Covington, LA 10/10 Excellent "We loved staying here!! It was so clean, comfortable, and everyone was so friendly! We will definitely stay here every time we come to this area. " [](https://expedia.ca/Hammond-Hotels-Country-Inn-Suites-By-Radisson.h2804087.Hotel-Information) ![Heritage Inn Picayune](//images.trvl-media.com/lodging/3000000/2460000/2455400/2455338/c2f5774a_y.jpg) ### Heritage Inn Picayune 10/10 Excellent "Clean rooms, excellent customer service." [](https://expedia.ca/Picayune-Hotels-Heritage-Inn-Picayune.h2455338.Hotel-Information) ![Motel 6 Bay Saint Louis, MS](//images.trvl-media.com/lodging/1000000/790000/788800/788703/b99f5e7a_y.jpg) ### Motel 6 Bay Saint Louis, MS 10/10 Excellent "Nice staff" [](https://expedia.ca/Biloxi-Hotels-Motel-6-Bay-Saint-Louis.h788703.Hotel-Information) ![Holiday Inn Express Slidell by IHG](//images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/5afce122_y.jpg) ### Holiday Inn Express Slidell by IHG 10/10 Excellent "Everything was good at the hotel. No complaints whatsoever. " [](https://expedia.ca/New-Orleans-Hotels-Holiday-Inn-Express-Slidell.h9766950.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Picayune cost? > Rates for business hotels in Picayune range between CA $96 and CA $156 per night. No matter your budget, Expedia can help you find the right place for a smooth work trip. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best business-friendly hotels in Picayune? > Picayune has multiple business-friendly hotels with a total average guest review rating of 8.0. One of the most popular is [Holiday Inn Express Picayune-Stennis Space Centre, an IHG Hotel](https://www.expedia.ca/Picayune-Hotels-Holiday-Inn-Express-Picayune-Stennis-Space-Center.h2665063.Hotel-Information). Get the job done from this 2.5-stars option, which includes pool sun loungers and a swimming pool. Another favourite with corporate travellers is [Heritage Inn Picayune](https://www.expedia.ca/Picayune-Hotels-Heritage-Inn-Picayune.h2455338.Hotel-Information). It has a 2-stars rating and amenities such as complimentary breakfast and front desk services. ### How many business-friendly hotels are there in Picayune? > Picayune offers 4 hotels that accommodate corporate travellers. Whether you're searching for a central location or conveniences such as conference rooms and dependable WiFi, you'll find the perfect property on Expedia. ### What are the top business-friendly motels in Picayune? > [Super 8 by Wyndham Picayune](https://www.expedia.ca/Picayune-Hotels-Super-8-By-Wyndham-Picayune.h1926144.Hotel-Information) perfectly combines work and play. A garden and a barbecue grill are among the many amenities at this business-friendly option, located around 3 kilometres northeast of the centre of Picayune.You'll find plenty of things to see and experience around Picayune. Take time out from your work schedule to visit leading attractions like [Millbrook Country Club](https://www.expedia.ca/Millbrook-Country-Club-Picayune.d6317721.Vacation-Attraction) and [Crosby Arboretum](https://www.expedia.ca/Crosby-Aboretum-Picayune.d6317725.Vacation-Attraction). ### Are there any family-friendly hotels in Picayune that are also business friendly? > Family travellers and corporate guests are well cared for at [Holiday Inn Express Picayune-Stennis Space Centre, an IHG Hotel](https://www.expedia.ca/Picayune-Hotels-Holiday-Inn-Express-Picayune-Stennis-Space-Center.h2665063.Hotel-Information). This popular 2.5-stars property in Picayune comes with a good range of amenities, such as complimentary breakfast and housekeeping services. Picayune has loads of family-friendly attractions to discover when you're done with work. Take the kids on an outing to [Crosby Arboretum](https://www.expedia.ca/Crosby-Aboretum-Picayune.d6317725.Vacation-Attraction) and [Millbrook Country Club](https://www.expedia.ca/Millbrook-Country-Club-Picayune.d6317721.Vacation-Attraction). ### Why book your business-friendly hotel in Picayune with Expedia? > With amenities like conference rooms, room service and on-site cafés, our business-friendly properties come with all you'll need to get the job done — and then unwind! Enter your preferred travel dates and destination and Expedia will help you organize the rest. ### How can I find cheap business-friendly hotels in Picayune? > When work takes you on the road in Picayune, our "business friendly" filter will help you find the right hotel. From free WiFi and included breakfast to meeting rooms and workspaces, they come with the amenities you need to be productive. Another tip? Narrow your search by your budget and preferred star rating to see the most affordable accommodations. ### What is there to do in Picayune near my business-friendly hotel? > If you want to make the most of your downtime in Picayune, don't miss [Millbrook Country Club](https://www.expedia.ca/Millbrook-Country-Club-Picayune.d6317721.Vacation-Attraction). It's popular with travellers and locals alike. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Long Beach](https://www.expedia.ca/5Star-Long-Beach-Hotels.s50-0-d55801.Travel-Guide-Filter-Hotels) - [Aparthotels in Bay St Louis](https://www.expedia.ca/Bay-St-Louis-Apart-Hotels.d183444-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Bay St Louis](https://www.expedia.ca/Bay-St-Louis-Bed-And-Breakfast.d183444-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cottages in Bay St Louis](https://www.expedia.ca/Bay-St-Louis-Cottages.d183444-aaCottages.Travel-Guide-Accommodation) - [Guest Houses in Bay St Louis](https://www.expedia.ca/Bay-St-Louis-Guest-Houses.d183444-aaGuestHouses.Travel-Guide-Accommodation) - [Beach Hotel Hotels in Bay St Louis](https://www.expedia.ca/Bay-St-Louis-Hotels-Beach-Hotel.0-0-d183444-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Bay St Louis](https://www.expedia.ca/Bay-St-Louis-Hotels-Boutique-Hotel.0-0-d183444-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - 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