Title: Book the Best BUSINESS Hotels in Picayune in 2026 | Expedia.ca [Hotels in Picayune](https://expedia.ca/Picayune-Hotels.d9372.Travel-Guide-Hotels)[Vacation Rentals in Picayune](https://expedia.ca/Picayune-Vacation-Rentals.d9372.Travel-Guide-VacationRentals)[Flights to Picayune](https://expedia.ca/Cheap-Flights-To-Picayune.d9372.Travel-Guide-Flights)[Picayune Car Rentals](https://expedia.ca/Car-Rentals-In-Picayune.d9372.Car-Rental-Guide)[Picayune Vacation Packages](https://expedia.ca/Picayune.d9372.Destination-Travel-Guides) ![A great blue heron in a swamp](https://images.trvl-media.com/place/9372/7fddd38d-614f-4323-956a-7714ea7f8ebb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9372/7fddd38d-614f-4323-956a-7714ea7f8ebb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Picayune Business Hotels Tonight [Jan 29 - Jan 30](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2026-01-29&endDate=2026-01-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 30 - Jan 31](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2026-01-30&endDate=2026-01-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Picayune business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/6493ec5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/3fa92acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/0d0c1424.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/3c2b6663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Picayune-Stennis Space Center by IHG [](https://www.expedia.ca/Picayune-Hotels-Holiday-Inn-Express-Picayune-Stennis-Space-Center.h2665063.Hotel-Information) Picayune 9.0/10 Wonderful (647 reviews) "Clean room staff was great air conditioning was super and breakfast was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Haley CA $145 CA $158 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Picayune-Hotels-Holiday-Inn-Express-Picayune-Stennis-Space-Center.h2665063.Hotel-Information) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/88239f1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/60c19139.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, towels](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/dec63a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1930000/1926200/1926144/94a1e4f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Picayune [](https://www.expedia.ca/Picayune-Hotels-Super-8-By-Wyndham-Picayune.h1926144.Hotel-Information) Picayune 6.4/10 (230 reviews) "Dirty ,, had a big roach crawling on me while sleeping, no phone in the room, no wifi " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Perla CA $71 CA $78 total includes taxes & fees Feb 20 - Feb 21 [](https://www.expedia.ca/Picayune-Hotels-Super-8-By-Wyndham-Picayune.h1926144.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/e69597e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/a638d545.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/672a4ddf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/70000/61100/61048/f94cd31a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Picayune [](https://www.expedia.ca/Picayune-Hotels-Econo-Lodge-Picayune.h61048.Hotel-Information) Picayune 6.2/10 (135 reviews) "The staff was friendly and it was very quiet. The pool was not open and the room could really use updating." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather CA $90 CA $98 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Picayune-Hotels-Econo-Lodge-Picayune.h61048.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/5ac349d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/902940fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/f3c44ff0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/102000000/101540000/101532600/101532511/e5baf271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Slidell I-10 [](https://www.expedia.ca/New-Orleans-Hotels-Quality-Inn.h101532511.Hotel-Information) Slidell 7.8/10 Good (310 reviews) "Breakfast was good, location excellent, and room was well maintained." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bhadhan CA $79 CA $93 total includes taxes & fees Feb 11 - Feb 12 [](https://www.expedia.ca/New-Orleans-Hotels-Quality-Inn.h101532511.Hotel-Information) ![Standard Room, 2 Queen Beds, Accessible](https://images.trvl-media.com/lodging/4000000/3560000/3555800/3555701/272d5087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3560000/3555800/3555701/d21a0f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3560000/3555800/3555701/069e5df8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed](https://images.trvl-media.com/lodging/4000000/3560000/3555800/3555701/033d3afe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Pearl River/Slidell [](https://www.expedia.ca/New-Orleans-Hotels-Microtel-Inn-Suites-By-Wyndham-Pearl-RiverSlidell.h3555701.Hotel-Information) Pearl River 8.0/10 Very good (1,001 reviews) "Clean room and great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric CA $95 CA $111 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/New-Orleans-Hotels-Microtel-Inn-Suites-By-Wyndham-Pearl-RiverSlidell.h3555701.Hotel-Information) ![Suite, 2 Queen Beds](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/5afce122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/c715f620.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/517d5f0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/f5abc0dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Slidell by IHG [](https://www.expedia.ca/New-Orleans-Hotels-Holiday-Inn-Express-Slidell.h9766950.Hotel-Information) Slidell 9.4/10 Exceptional (959 reviews) "Great breakfast, great rooms, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janet CA $160 CA $185 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/New-Orleans-Hotels-Holiday-Inn-Express-Slidell.h9766950.Hotel-Information) ![Indoor pool, open 9:00 AM to 8:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/49900/49812/a5d7415f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking (Pet-Friendly, Exterior)](https://images.trvl-media.com/lodging/1000000/50000/49900/49812/7f2a1993.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/50000/49900/49812/w794h565x3y4-ca5a4d6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/49900/49812/2531a1ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Diamondhead I-10/Gulfport [](https://www.expedia.ca/Biloxi-Hotels-Ramada-By-Wyndham-Diamondhead-I-10Gulfport.h49812.Hotel-Information) Diamondhead 8.0/10 Very good (590 reviews) "Nice quiet getaway spot." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laci CA $93 CA $102 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Biloxi-Hotels-Ramada-By-Wyndham-Diamondhead-I-10Gulfport.h49812.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/86740aab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/3d56d639.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/b9e2395e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/b646a50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Silver Slipper Casino & Hotel - Adults Only [](https://www.expedia.ca/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) Bay St Louis 8.6/10 Excellent (1,000 reviews) "Clean room... friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $96 CA $105 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/5844a2ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/a310d173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, down comforters, individually decorated](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/ef5b0095.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, down comforters, individually decorated](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/f3c6bfab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Slidell - New Orleans Area [](https://www.expedia.ca/New-Orleans-Hotels-Comfort-Inn-Suites.h11266063.Hotel-Information) Slidell 8.6/10 Excellent (1,000 reviews) "Rooms were very clean, breakfast was great. Staff was very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) B CA $135 CA $157 total includes taxes & fees Feb 4 - Feb 5 [](https://www.expedia.ca/New-Orleans-Hotels-Comfort-Inn-Suites.h11266063.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/00bba3b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/a33e6452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/6130fa7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/530000/526400/526304/b6ab6dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Slidell [](https://www.expedia.ca/New-Orleans-Hotels-Sleep-Inn-Slidell.h526304.Hotel-Information) Slidell 8.2/10 Very good (659 reviews) "Rooms were good, staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carol CA $105 CA $122 total includes taxes & fees Feb 4 - Feb 5 [](https://www.expedia.ca/New-Orleans-Hotels-Sleep-Inn-Slidell.h526304.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-12&endDate=2026-02-13®ionId=9372&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Picayune Hotel Reviews ![Holiday Inn Express Picayune-Stennis Space Center by IHG](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665063/f291f597_y.jpg) ### Holiday Inn Express Picayune-Stennis Space Center by IHG 10/10 Excellent "Good stay " [](https://expedia.ca/Picayune-Hotels-Holiday-Inn-Express-Picayune-Stennis-Space-Center.h2665063.Hotel-Information) ![Comfort Inn & Suites](https://images.trvl-media.com/lodging/12000000/11270000/11266100/11266063/5844a2ef_y.jpg) ### Comfort Inn & Suites 10/10 Excellent "Room very clean Nice hostess at check in I have ordered on Instacart and girl very kind at desk " [](https://expedia.ca/New-Orleans-Hotels-Comfort-Inn-Suites.h11266063.Hotel-Information) ![The Southern Hotel](https://images.trvl-media.com/lodging/17000000/16240000/16232600/16232549/1cf33af6_y.jpg) ### The Southern Hotel 10/10 Excellent "Great place. Well kept room. Restaurant and lounge were very enjoyable" [](https://expedia.ca/Hammond-Hotels-The-Southern-Hotel.h16232549.Hotel-Information) ![Microtel Inn & Suites by Wyndham Pearl River/Slidell](https://images.trvl-media.com/lodging/4000000/3560000/3555800/3555701/c7e2db74_y.jpg) ### Microtel Inn & Suites by Wyndham Pearl River/Slidell 10/10 Excellent "Nice staff, very clean room , quiet air, good water pressure in the shower " [](https://expedia.ca/New-Orleans-Hotels-Microtel-Inn-Suites-By-Wyndham-Pearl-RiverSlidell.h3555701.Hotel-Information) ![Suburban Studios Slidell I-10](https://images.trvl-media.com/lodging/1000000/30000/20400/20353/82c2ce3c_y.jpg) ### Suburban Studios Slidell I-10 10/10 Excellent "Room was very clean Staff super nice" [](https://expedia.ca/New-Orleans-Hotels-La-Quinta-Inn-By-Wyndham-New-Orleans-Slidell.h20353.Hotel-Information) ![Courtyard by Marriott New Orleans Covington/Mandeville](https://images.trvl-media.com/lodging/1000000/70000/64200/64156/d6215bcf_y.jpg) ### Courtyard by Marriott New Orleans Covington/Mandeville 10/10 Excellent "Great location, wonderful staff!" [](https://expedia.ca/Hammond-Hotels-Courtyard-By-Marriott-New-Orleans-CovingtonMandeville.h64156.Hotel-Information) ![Holiday Inn Express Slidell by IHG](https://images.trvl-media.com/lodging/10000000/9770000/9767000/9766950/5afce122_y.jpg) ### Holiday Inn Express Slidell by IHG 10/10 Excellent "Melissa at check in was wonderful, nice and helpful. Room was clean. Breakfast is good." [](https://expedia.ca/New-Orleans-Hotels-Holiday-Inn-Express-Slidell.h9766950.Hotel-Information) ![Hollywood Casino Gulf Coast](https://images.trvl-media.com/lodging/1000000/530000/526700/526688/d677d4b8_y.jpg) ### Hollywood Casino Gulf Coast 10/10 Excellent "The place is clean. " [](https://expedia.ca/Biloxi-Hotels-Hollywood-Casino-Gulf-Coast.h526688.Hotel-Information) ![Holiday Inn Covington by IHG](https://images.trvl-media.com/lodging/9000000/8380000/8370400/8370311/954b4dc8_y.jpg) ### Holiday Inn Covington by IHG 10/10 Excellent "clean" [](https://expedia.ca/Hammond-Hotels-Holiday-Inn-Covington.h8370311.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Picayune cost? ### What are the best business-friendly hotels in Picayune? ### How many business-friendly hotels are there in Picayune? ### What are the top business-friendly motels in Picayune? ### Are there any family-friendly hotels in Picayune that are also business friendly? ### Why book your business-friendly hotel in Picayune with Expedia? ### How can I find cheap business-friendly hotels in Picayune? ### What is there to do in Picayune near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - 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