Title: Book the Best Panajachel LUXURY Hotels - Upscale Hotels in Panajachel | Expedia.ca

[Panajachel Travel Guide](https://expedia.ca/Panajachel.dx181076)[Hotels in Panajachel](https://expedia.ca/Panajachel-Hotels.d181076.Travel-Guide-Hotels)[Vacation Rentals in Panajachel](https://expedia.ca/Panajachel-Vacation-Rentals.d181076.Travel-Guide-VacationRentals)[Flights to Panajachel](https://expedia.ca/Cheap-Flights-To-Panajachel.d181076.Travel-Guide-Flights)[Things to do in Panajachel](https://expedia.ca/Things-To-Do-In-Panajachel.d181076.Travel-Guide-Activities)[Panajachel Car Rentals](https://expedia.ca/Car-Rentals-In-Panajachel.d181076.Car-Rental-Guide)[Panajachel Vacation Packages](https://expedia.ca/Panajachel.d181076.Destination-Travel-Guides)

![Panajachel which includes a lake or waterhole, boating and a bay or harbour](https://images.trvl-media.com/place/181076/cb7be885-1ee3-4064-aa5b-5d1d15a380f1.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/181076/cb7be885-1ee3-4064-aa5b-5d1d15a380f1.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Panajachel Luxury Hotels

Tonight

[Jan 22 - Jan 23](https://www.expedia.ca/Hotel-Search?regionId=181076&startDate=2026-01-22&endDate=2026-01-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Tomorrow

[Jan 23 - Jan 24](https://www.expedia.ca/Hotel-Search?regionId=181076&startDate=2026-01-23&endDate=2026-01-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

This weekend

[Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=181076&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Next weekend

[Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=181076&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

## Our top choices for Panajachel luxury hotels

![Land view from property](https://images.trvl-media.com/lodging/7000000/6620000/6611300/6611297/7ddeccb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Room, 1 King Bed, Lake View](https://images.trvl-media.com/lodging/7000000/6620000/6611300/6611297/e1d7e500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden](https://images.trvl-media.com/lodging/7000000/6620000/6611300/6611297/9349e6cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/7000000/6620000/6611300/6611297/8c0479ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Atitlán

[](https://www.expedia.ca/Panajachel-Hotels-Hotel-Atitlan.h6611297.Hotel-Information)

Solola

9.0/10

Wonderful

(718 reviews)

" Beautiful resort, excellent service."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael

CA $332

CA $405 total

includes taxes & fees

Feb 2 - Feb 3

[](https://www.expedia.ca/Panajachel-Hotels-Hotel-Atitlan.h6611297.Hotel-Information)

![Garden](https://images.trvl-media.com/lodging/3000000/2600000/2594900/2594806/f9e92aec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor treatment areas, sauna, hot springs, aromatherapy](https://images.trvl-media.com/lodging/3000000/2600000/2594900/2594806/7ef4dd36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hot springs](https://images.trvl-media.com/lodging/3000000/2600000/2594900/2594806/a8839f3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room | View from room](https://images.trvl-media.com/lodging/3000000/2600000/2594900/2594806/de47a299.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Regis Hotel & Spa

[](https://www.expedia.ca/Panajachel-Hotels-Regis-Hotel-Spa.h2594806.Hotel-Information)

Panajachel

8.8/10

Excellent

(674 reviews)

"Friendly staff, clean rooms. Great breakfast"

![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg)

Henk

CA $92

CA $120 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Panajachel-Hotels-Regis-Hotel-Spa.h2594806.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-05&endDate=2026-02-06&regionId=181076&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true)

## Top Panajachel Hotel Reviews

![Regis Hotel & Spa](https://images.trvl-media.com/lodging/3000000/2600000/2594900/2594806/f9e92aec_y.jpg)

### Regis Hotel & Spa

10/10 Excellent

"Location of hotel is perfect, in the middle of town but set back into lovely gardens so that you are away from noise and pollution of road. The hot spa is very relaxing and appreciated ! Staff is attentive and always cheerful. Rooms are clean, basic and in line with the rest of the place . "

[](https://expedia.ca/Panajachel-Hotels-Regis-Hotel-Spa.h2594806.Hotel-Information)

## Frequently asked questions

### Which area of Panajachel is best to stay in for luxury hotels?

> Calle Santander is the main thoroughfare in Panajachel, stretching from the town centre down to Lake Atitlán. It's lined with shops, restaurants, and tour operators, making it a convenient base. The luxury hotels here often boast private lake access, stunning views of the volcanoes, and well-maintained gardens. This area provides a blend of easy access to town amenities and the tranquillity of the lakeside.
> 
>   
> Couples looking for a relaxing and comfortable escape will find this area particularly appealing. The hotels often feature amenities like infinity pools, high-end fitness equipment, and spa services. Many rooms offer balconies with direct lake views, superb for enjoying a morning coffee or an evening sunset.

### How much does a luxury hotel in Panajachel cost?

### What luxury activities and experiences are there in Panajachel?

> This area is Panajachel's main street, running from the town centre down to Lake Atitlán. It's bustling with local craft markets, art galleries, and a good selection of restaurants and cafes. The street itself is lively, leading directly to the public beach and boat docks, where you can easily arrange private tours.
> 
>   
> Couples looking for an indulgent escape will find the lakeside resorts here particularly appealing. Many offer private bungalows with stunning lake views, infinity pools, and access to private docks for exclusive boat tours of the lake and its villages. You can also arrange private cooking classes focusing on local cuisine or enjoy spa treatments with views of the volcanoes.
> 
>   
> For those seeking unique cultural experiences, the area around Calle Santander also provides opportunities to commission bespoke artwork from local artists or arrange private textile weaving workshops.

### How can I save on a luxury hotel in Panajachel with Expedia?

### Is it cheaper to book a luxury Panajachel hotel and flights as a package?

### Can I cancel my luxury hotel reservation on Expedia?

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