Title: Book the Best Panacea LUXURY Hotels - Upscale Hotels in Panacea, FL | Expedia.ca [Panacea Travel Guide](https://expedia.ca/Panacea.dx3000431554)[Hotels in Panacea](https://expedia.ca/Panacea-Hotels.d3000431554.Travel-Guide-Hotels)[Vacation Rentals in Panacea](https://expedia.ca/Panacea-Vacation-Rentals.d3000431554.Travel-Guide-VacationRentals)[Panacea Car Rentals](https://expedia.ca/Car-Rentals-In-Panacea.d3000431554.Car-Rental-Guide)[Panacea Vacation Packages](https://expedia.ca/Panacea.d3000431554.Destination-Travel-Guides) ![Sunset over a lake at Panacea, northern Florida, USA | NONE |](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Panacea Luxury Hotels Tonight [Jan 21 - Jan 22](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2026-01-21&endDate=2026-01-22&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Jan 22 - Jan 23](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2026-01-22&endDate=2026-01-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=3000431554&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Panacea Hotel Reviews ## Frequently asked questions ### Which area of Panacea is best to stay in for luxury hotels? > This area is characterised by its direct access to the Gulf of Mexico, offering properties with private beach access or stunning bay views. You'll find a selection of high-end resorts and boutique hotels here, often featuring amenities like infinity pools, fine dining restaurants, and high-end fitness equipment. The general layout is linear, following the coastline, with most establishments capitalising on the natural beauty of the waterfront. > > > Couples looking for a romantic escape will find this area particularly appealing. The serene setting, often accompanied by sunset views over the water, provides a tranquil backdrop for a luxurious holiday. Many hotels here offer spa services and secluded dining options, great for an intimate experience. > > > For those seeking a focus on wellness and relaxation, the luxury hotels in this waterfront district are an excellent choice. The proximity to the water allows for activities like paddleboarding or kayaking, and many hotels provide organised excursions. ### How much does a luxury hotel in Panacea cost? ### What luxury activities and experiences are there in Panacea? > For those seeking an exclusive aquatic adventure, consider chartering a private yacht or fishing boat. This allows for bespoke itineraries, whether it's deep-sea fishing for prized catches, exploring secluded coves along the Gulf Coast, or simply enjoying a sunset cruise with gourmet catering. Several local operators specialise in high-end charters, providing experienced crew and top-tier vessels. > > > Food connoisseurs will appreciate the opportunity to indulge in fresh, local seafood at Panacea's upscale dining establishments. Many restaurants here pride themselves on serving daily catches, often prepared with a sophisticated Floridian twist. Look for places offering waterfront dining for an added touch of elegance, where you can enjoy exquisite meals with panoramic views of the bay. > > > Relaxation and rejuvenation can be found at some of the area's refined wellness centres or by arranging private spa services. ### How can I save on a luxury hotel in Panacea with Expedia? ### Is it cheaper to book a luxury Panacea hotel and flights as a package? ### Can I cancel my luxury hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [2 Star Hotels in Carrabelle ](https://www.expedia.ca/2Star-Carrabelle-Hotels.s20-0-d86458.Travel-Guide-Filter-Hotels) - [Farmstay in Alligator Point ](https://www.expedia.ca/Alligator-Point-Agritourism.d553248635975849030-aaAgritourism.Travel-Guide-Accommodation) - [Beach Hotel Hotels in Alligator Point ](https://www.expedia.ca/Alligator-Point-Hotels-Beach-Hotel.0-0-d553248635975849030-tBeachHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Alligator Point ](https://www.expedia.ca/Alligator-Point-Hotels-Cheap-Hotels.0-0-d553248635975849030-tCheapHotels.Travel-Guide-Filter-Hotels) - [Alligator Point Hotels ](https://www.expedia.ca/Alligator-Point-Hotels.d553248635975849030.Travel-Guide-Hotels) - [Lodges in Alligator Point ](https://www.expedia.ca/Alligator-Point-Lodges.d553248635975849030-aaLodges.Travel-Guide-Accommodation) - [Hotels near Apalachicola National Forest ](https://www.expedia.ca/Apalachicola-National-Forest-Hotels.0-l6063719-0.Travel-Guide-Filter-Hotels) - [Hotels near Bald Point State Park ](https://www.expedia.ca/Bald-Point-State-Park-Hotels.0-l553248621532654045-0.Travel-Guide-Filter-Hotels) - [B&B in Carrabelle ](https://www.expedia.ca/Carrabelle-Bed-And-Breakfast.d86458-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Beach Hotel Hotels in Carrabelle ](https://www.expedia.ca/Carrabelle-Hotels-Beach-Hotel.0-0-d86458-tBeachHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Carrabelle ](https://www.expedia.ca/Carrabelle-Hotels-Cheap-Hotels.0-0-d86458-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Carrabelle ](https://www.expedia.ca/Carrabelle-Hotels-Luxury-Hotel.0-0-d86458-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Carrabelle ](https://www.expedia.ca/Carrabelle-Hotels-Pet-Friendly-Hotel.0-0-d86458-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Shopping Hotels in Carrabelle ](https://www.expedia.ca/Carrabelle-Hotels-Shopping-Hotel.0-0-d86458-tShoppingHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Carrabelle ](https://www.expedia.ca/Carrabelle-Hotels-Spa-Hotel.0-0-d86458-tSpaHotel.Travel-Guide-Filter-Hotels) - [Carrabelle Hotels ](https://www.expedia.ca/Carrabelle-Hotels.d86458.Travel-Guide-Hotels) - [Inns in Carrabelle ](https://www.expedia.ca/Carrabelle-Inns.d86458-aaInns.Travel-Guide-Accommodation) - [Lodges in Carrabelle ](https://www.expedia.ca/Carrabelle-Lodges.d86458-aaLodges.Travel-Guide-Accommodation) - [Motels in Carrabelle ](https://www.expedia.ca/Carrabelle-Motels.d86458-aaMotels.Travel-Guide-Accommodation) - [Resorts in Carrabelle ](https://www.expedia.ca/Carrabelle-Resort-Hotels.d86458-aaResortHotels.Travel-Guide-Accommodation) - [Beach Hotel Hotels in College Town ](https://www.expedia.ca/College-Town-Tallahassee-Hotels-Beach-Hotel.0-n553248635976477953-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Apartments in Crawfordville ](https://www.expedia.ca/Crawfordville-Apartments.d183090-aaApartments.Travel-Guide-Accommodation) - [Cabin Rentals in Crawfordville ](https://www.expedia.ca/Crawfordville-Cabins.d183090-aaCabins.Travel-Guide-Accommodation) - [Cheap Hotels in Crawfordville ](https://www.expedia.ca/Crawfordville-Hotels-Cheap-Hotels.0-0-d183090-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Crawfordville ](https://www.expedia.ca/Crawfordville-Hotels-Luxury-Hotel.0-0-d183090-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Crawfordville Hotels ](https://www.expedia.ca/Crawfordville-Hotels.d183090.Travel-Guide-Hotels) - [Motels in Crawfordville ](https://www.expedia.ca/Crawfordville-Motels.d183090-aaMotels.Travel-Guide-Accommodation) - [Beach Hotel Hotels in Wakulla County ](https://www.expedia.ca/Destinations-In-Wakulla-County-Beach-Hotel.0-0-d553248635083916428-tBeachHotel.Hotel-Filter-Destinations) - [Chalets in Dog Island ](https://www.expedia.ca/Dog-Island-Chalets.d553248633992414405-aaChalets.Travel-Guide-Accommodation) - [Condo Rentals in Dog Island ](https://www.expedia.ca/Dog-Island-Condos.d553248633992414405-aaCondos.Travel-Guide-Accommodation) - [Cottages in Dog Island ](https://www.expedia.ca/Dog-Island-Cottages.d553248633992414405-aaCottages.Travel-Guide-Accommodation) - [Guest Houses in Dog Island ](https://www.expedia.ca/Dog-Island-Guest-Houses.d553248633992414405-aaGuestHouses.Travel-Guide-Accommodation) - [Cheap Hotels in Dog Island ](https://www.expedia.ca/Dog-Island-Hotels-Cheap-Hotels.0-0-d553248633992414405-tCheapHotels.Travel-Guide-Filter-Hotels) - [Dog Island Hotels ](https://www.expedia.ca/Dog-Island-Hotels.d553248633992414405.Travel-Guide-Hotels) - [Inns in Dog Island ](https://www.expedia.ca/Dog-Island-Inns.d553248633992414405-aaInns.Travel-Guide-Accommodation) - [Motels in Dog Island ](https://www.expedia.ca/Dog-Island-Motels.d553248633992414405-aaMotels.Travel-Guide-Accommodation) - [Vacation Homes in Dog Island ](https://www.expedia.ca/Dog-Island-Private-Vacation-Homes.d553248633992414405-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Chalets in Lanark Village ](https://www.expedia.ca/Lanark-Village-Chalets.d553248635975876519-aaChalets.Travel-Guide-Accommodation) - [Guest Houses in Lanark Village ](https://www.expedia.ca/Lanark-Village-Guest-Houses.d553248635975876519-aaGuestHouses.Travel-Guide-Accommodation) - [Cheap Hotels in Lanark Village ](https://www.expedia.ca/Lanark-Village-Hotels-Cheap-Hotels.0-0-d553248635975876519-tCheapHotels.Travel-Guide-Filter-Hotels) - [Lanark Village Hotels ](https://www.expedia.ca/Lanark-Village-Hotels.d553248635975876519.Travel-Guide-Hotels) - [Lodges in Lanark Village ](https://www.expedia.ca/Lanark-Village-Lodges.d553248635975876519-aaLodges.Travel-Guide-Accommodation) - [Medart Hotels ](https://www.expedia.ca/Medart-Hotels.d553248635975866185.Travel-Guide-Hotels) - [Newport Hotels ](https://www.expedia.ca/Newport-Hotels.d553248635975872209.Travel-Guide-Hotels) - [Ochlockonee Bay Hotels ](https://www.expedia.ca/Ochlockonee-Bay-Hotels.d553248635975855809.Travel-Guide-Hotels) - [Hotels near Ochlockonee River State Park ](https://www.expedia.ca/Ochlockonee-River-State-Park-Hotels.0-l553248621532653556-0.Travel-Guide-Filter-Hotels) - [Business Hotels in Panama City Beach ](https://www.expedia.ca/Panama-City-Beach-Hotels-Business-Hotel.0-0-d8021-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Panama City Beach ](https://www.expedia.ca/Panama-City-Beach-Hotels-Couples-Resorts-Hotels.0-0-d8021-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Panama City Beach ](https://www.expedia.ca/Panama-City-Beach-Hotels-Historic-Hotel.0-0-d8021-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Panama City Beach ](https://www.expedia.ca/Panama-City-Beach-Hotels-Hotel-With-Early-Check-In.0-0-d8021-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Hotels with Wifi in Panama City Beach ](https://www.expedia.ca/Panama-City-Beach-Hotels-Hotel-With-Wifi.0-0-d8021-tHotelwithwifi.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in Panama City Beach ](https://www.expedia.ca/Panama-City-Beach-Hotels-Scuba-Diving-Vacations.0-0-d8021-tscubadivingvacations.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Panama City ](https://www.expedia.ca/Panama-City-Hotels-Hotels-With-Free-Parking.0-0-d6023330-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Lake Hotels in Panama City ](https://www.expedia.ca/Panama-City-Hotels-Lake-Hotels.0-0-d6023330-tLakeHotels.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Panama City ](https://www.expedia.ca/Panama-City-Hotels-Mountain-Hotels.0-0-d6023330-tMountainHotels.Travel-Guide-Filter-Hotels) - [Saint Teresa Hotels ](https://www.expedia.ca/Saint-Teresa-Hotels.d3000432006.Travel-Guide-Hotels) - [Hotels near Shell Point Beach ](https://www.expedia.ca/Shell-Point-Beach-Hotels.0-l553248635976197335-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Sopchoppy ](https://www.expedia.ca/Sopchoppy-Hotels-Cheap-Hotels.0-0-d6355340-tCheapHotels.Travel-Guide-Filter-Hotels) - [Sopchoppy Hotels ](https://www.expedia.ca/Sopchoppy-Hotels.d6355340.Travel-Guide-Hotels) - [Cheap Hotels in St. Marks ](https://www.expedia.ca/St-Marks-Hotels-Cheap-Hotels.0-0-d6348000-tCheapHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in St. Marks ](https://www.expedia.ca/St-Marks-Hotels-Pet-Friendly-Hotel.0-0-d6348000-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [St. Marks Hotels ](https://www.expedia.ca/St-Marks-Hotels.d6348000.Travel-Guide-Hotels) - [Hotels near St. Marks National Wildlife Refuge ](https://www.expedia.ca/St-Marks-National-Wildlife-Refuge-Hotels.0-l6063701-0.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-All-Inclusive-Hotel.0-0-d6048214-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Beach-Hotel.0-0-d6048214-tBeachHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Cheap-Hotels.0-0-d6048214-tCheapHotels.Travel-Guide-Filter-Hotels) - [Golf Hotels in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Golf-Hotel.0-0-d6048214-tGolfHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Historic-Hotel.0-0-d6048214-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Hotel-With-Pool.0-0-d6048214-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d6048214-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Hotels-With-Free-Breakfast.0-0-d6048214-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Luxury-Hotel.0-0-d6048214-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Tallahassee ](https://www.expedia.ca/Tallahassee-Hotels-Pet-Friendly-Hotel.0-0-d6048214-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Wakulla Beach Hotels ](https://www.expedia.ca/Wakulla-Beach-Hotels.d553248635975849044.Travel-Guide-Hotels) - [Vacation Homes in Wakulla Beach ](https://www.expedia.ca/Wakulla-Beach-Private-Vacation-Homes.d553248635975849044-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Aparthotels in Wakulla Springs ](https://www.expedia.ca/Wakulla-Springs-Apart-Hotels.d553248635077778744-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Wakulla Springs ](https://www.expedia.ca/Wakulla-Springs-Bed-And-Breakfast.d553248635077778744-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Wakulla Springs ](https://www.expedia.ca/Wakulla-Springs-Cabins.d553248635077778744-aaCabins.Travel-Guide-Accommodation) - [Hostels in Wakulla Springs ](https://www.expedia.ca/Wakulla-Springs-Hostels.d553248635077778744-aaHostels.Travel-Guide-Accommodation) - [Cheap Hotels in Wakulla Springs ](https://www.expedia.ca/Wakulla-Springs-Hotels-Cheap-Hotels.0-0-d553248635077778744-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Wakulla Springs ](https://www.expedia.ca/Wakulla-Springs-Hotels-Luxury-Hotel.0-0-d553248635077778744-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Wakulla Springs Hotels ](https://www.expedia.ca/Wakulla-Springs-Hotels.d553248635077778744.Travel-Guide-Hotels) - [Hotels near Wakulla Springs State Park ](https://www.expedia.ca/Wakulla-Springs-State-Park-Hotels.0-l6089879-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Woodville ](https://www.expedia.ca/Woodville-Hotels-Cheap-Hotels.0-0-d553248635975850490-tCheapHotels.Travel-Guide-Filter-Hotels) - [Flights to Alligator Point ](https://www.expedia.ca/Cheap-Flights-To-Alligator-Point.d553248635975849030.Travel-Guide-Flights) - [Flights to Carrabelle ](https://www.expedia.ca/Cheap-Flights-To-Carrabelle.d86458.Travel-Guide-Flights) - [Flights to Crawfordville ](https://www.expedia.ca/Cheap-Flights-To-Crawfordville.d183090.Travel-Guide-Flights) - [Flights to Dog Island ](https://www.expedia.ca/Cheap-Flights-To-Dog-Island.d553248633992414405.Travel-Guide-Flights) - [Flights from Carrabelle ](https://www.expedia.ca/lp/flights/86458/flights-from-carrabelle) - [Dog Island Vacations ](https://www.expedia.ca/Dog-Island.d553248633992414405.Destination-Travel-Guides) - [Visit Dog Island ](https://www.expedia.ca/Dog-Island.dx553248633992414405) - [Visit Medart ](https://www.expedia.ca/Medart.dx553248635975866185) - [St. Marks National Wildlife Refuge ](https://www.expedia.ca/St-Marks-National-Wildlife-Refuge-Crawfordville.d6063701.Vacation-Attraction) - [St. Marks Vacations ](https://www.expedia.ca/St-Marks.d6348000.Destination-Travel-Guides) - [Uss Mohawk CGC Veterans Memorial Reef ](https://www.expedia.ca/USS-Mohawk-CGC-Veterans-Memorial-Reef-Panacea.d553248621561885546.Vacation-Attraction) - [Car rental Crawfordville ](https://www.expedia.ca/Car-Rentals-In-Crawfordville.d183090.Car-Rental-Guide) - [Enterprise Rental Cars in Carrabelle ](https://www.expedia.ca/Enterprise-Car-Rentals-In-Carrabelle.d86458-c15.Car-Rental-Guide-Suppliers) - [Europcar Rental Cars in Alligator Point ](https://www.expedia.ca/Europcar-Car-Rentals-In-Alligator-Point.d553248635975849030-c14.Car-Rental-Guide-Suppliers) - [Carrabelle Vacation Rentals ](https://www.expedia.ca/Carrabelle-Vacation-Rentals.d86458.Travel-Guide-VacationRentals) - [Dog Island Vacation Rentals ](https://www.expedia.ca/Dog-Island-Vacation-Rentals.d553248633992414405.Travel-Guide-VacationRentals) - [Book Luxury Hotels in Panacea on Expedia.com ](https://www.expedia.com/Panacea-Hotels-Luxury-Hotel.0-0-d3000431554-tLuxuryHotel.Travel-Guide-Filter-Hotels)