Pamplico Vacation Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In one month
In two months
In three months

Browse Select Pamplico Vacation Homes

Our top choices for Pamplico vacation homes

Peaceful Farm Getaway

10.0 out of 10, Exceptional, (25)
"Lovely house! We were in town for a wedding and it was perfect for us."
The price is CA $169
CA $271 total
includes taxes & fees
Aug 24 - Aug 25
Peaceful Farm Getaway

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

10.0 out of 10, Exceptional, (26)
"Excellent house and property. Would definitely stay here again!"
The price is CA $231
CA $293 total
includes taxes & fees
Aug 24 - Aug 25
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Pineapple House: Historic. Southern Charm. Walk Downtown.

9.4 out of 10, Exceptional, (16)
"This was a very nice property and very comfortable. We enjoyed our stay there."
Pineapple House: Historic. Southern Charm. Walk Downtown.

Hickory Haven 3Br Elegant Downtown Hidden Gem

9.6 out of 10, Exceptional, (18)
"We stayed at the house for the Darlington race weekend. It was pretty close to the racetrack and was great size for what we needed. Not the best area but the house was great. "
Hickory Haven 3Br Elegant Downtown Hidden Gem

Cheerful home with plenty of privacy and entertainment room.

8.2 out of 10, Very good, (25)
"We had a wonderful stay. Three couples in for the race, house was perfect. "
Cheerful home with plenty of privacy and entertainment room.

Jacqueline Estates

10.0 out of 10, Exceptional, (10)
"The house was so beautiful! Everything we could have needed was provided. I will totally stay againnext time I'm in Florence "
Jacqueline Estates

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

9.6 out of 10, Exceptional, (5)
"Everything about this location was great and the host was very kind. Thank you for making our stay comfortable. "
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Quaint Bungalow in Historic Downtown Florence

10.0 out of 10, Exceptional, (15)
"Our second time to stay here and again found it to be charming, comfortable, and clean. Will definitely stay again!"
Quaint Bungalow in Historic Downtown Florence

Great Home in the Greater Florence Area

9.6 out of 10, Exceptional, (7)
"Thank you so much for sharing your home with us for the last 3 months. Everything was wonderful and comfortable stay. "
Great Home in the Greater Florence Area

Quiet, Clean & Spacious 4bd near I-95 & Hospital with WiFi

8.0 out of 10, Very good, (1)
"Lovely place!"
The price is CA $271
CA $605 total
includes taxes & fees
Aug 27 - Aug 28
Quiet, Clean & Spacious 4bd near I-95 & Hospital with WiFi

Cozy Mullins Retreat w/ Backyard & Covered Porch!

2.0 star property
8.8 out of 10, Excellent, (3)
"My staff and I were in Mullins the week of July 7-11 to facilitate a youth camp. The accommodations were just what we needed for a comfortable week. The house was clean and spacious, providing all the essentials we needed. The host was responsive to any of our needs. The neighborhood was quiet and convenient to downtown stores and shops. Overall, a great stay and we definitely plan to book again in the future."
Cozy Mullins Retreat w/ Backyard & Covered Porch!

Elegant Historic Home w/ Modern Touch in Florence

8.0 out of 10, Very good, (1)
"We came to visit my godchild and enjoyed visiting with his family. This home is a beautiful house and with it being a fairly new listing it had some hiccups that could be work on, but other then that the neighborhood is quite"
Elegant Historic Home w/ Modern Touch in Florence

Simple & Sweet 2-bedroom house in amazing Florence

7.0 out of 10, Good, (4)
"Awesome everything was cozy and functional. "
Simple & Sweet 2-bedroom house in amazing Florence

Walking distance from one of South Carolina's top Medical centers.

9.8 out of 10, Exceptional, (41)
"Clean, well stocked and very comfortable. I would definitely stay again if I am in the area."
The price is CA $186
CA $324 total
includes taxes & fees
Aug 24 - Aug 25
Walking distance from one of South Carolina's top Medical centers.

Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence!

9.0 out of 10, Wonderful, (6)
"It was a great place. "
The price is CA $277
CA $830 total
includes taxes & fees
Aug 25 - Aug 26
Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence!

Charming 3-bedroom house in Florence, SC

8.0 out of 10, Very good, (1)
"Property was clean and inviting. The only issue we had was the ac wasnt cool enough for us. (We work outside)"
Charming 3-bedroom house in Florence, SC

Charming 1-bedroom house in awesome Kingstree with AC, WiFi

Charming 1-bedroom house in awesome Kingstree with AC, WiFi

Luxury stay at 4 bedroom house

9.0 out of 10, Wonderful, (2)
"We needed a place to stay, close to a wedding venue and this house was Perfect for our large family. Very clean, roomy, and well stocked. Zilola was so nice and quick to respond."
Luxury stay at 4 bedroom house

Cozy Retreat in Florence, SC

Cozy Retreat in Florence, SC

2 bedroom home with cozy back porch retreat

2 bedroom home with cozy back porch retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Pamplico Hotel Reviews