Title: Pamplico Vacation Home Rentals from CA $251: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in Pamplico](https://expedia.ca/Pamplico-Hotels.d3000353197.Travel-Guide-Hotels)[Vacation Rentals in Pamplico](https://expedia.ca/Pamplico-Vacation-Rentals.d3000353197.Travel-Guide-VacationRentals)[Things to do in Pamplico](https://expedia.ca/Things-To-Do-In-Pamplico.d3000353197.Travel-Guide-Activities)[Pamplico Car Rentals](https://expedia.ca/Car-Rentals-In-Pamplico.d3000353197.Car-Rental-Guide)[Pamplico Vacation Packages](https://expedia.ca/Pamplico.d3000353197.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Pamplico Vacation Rentals ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-10-31&endDate=2025-11-02&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-11-07&endDate=2025-11-09&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-11-21&endDate=2025-11-23&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-12-19&endDate=2025-12-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Pamplico Vacation Homes ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ca6cd657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/31dca09e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/bd6a3dbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walking distance from one of South Carolina's top Medical centers. Florence 9.8/10 Exceptional (41) "Clean, well stocked and very comfortable. I would definitely stay again if I am in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peggy CA $126 CA $251 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/1f22847e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/d976ad14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, shampoo](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/bd28d6c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/b91b5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peaceful Farm Getaway Mullins 10/10 Exceptional (30) "The property is fantastic and so are the owners. Do not hesitate to book this property.!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teddy R. CA $189 CA $296 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Mullins-Hotels-Peaceful-Farm-Getaway.h94795059.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/f8c3716e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/94a0d867.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/dbbd1114.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/90a72a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence! Marion 9.0/10 Wonderful (6) "It was a great place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cindy N. CA $280 CA $836 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Marion-Hotels-Located-In-Marion-Only-1-Hour-From-Myrtle-Beach.h87657259.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/4c52a4d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/96e90379.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, foosball, books, computer monitors](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/6fcb0465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/116000000/115640000/115638400/115638333/04c9cb2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quiet, Clean & Spacious 4bd near I-95 & Hospital with WiFi Florence 9.4/10 Exceptional (3) "It’s a beautiful home in a quiet neighborhood. The owner was very responsive to questions. I’d definitely stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dawn L. CA $320 CA $671 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Florence-Hotels-Quiet.h115638333.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/d78ca460.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/23ea7b6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/0a272051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's Florence 10/10 Exceptional (31) "Property had everything we needed for a weekend stay for a wedding. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cortney B. CA $330 CA $418 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-07&endDate=2025-11-08®ionId=3000353197&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPamplico-Private-Vacation-Homes.d3000353197-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPamplico-Private-Vacation-Homes.d3000353197-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Pamplico Hotel Reviews ![La Quinta Inn & Suites by Wyndham Florence](//images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695_y.jpg) ### La Quinta Inn & Suites by Wyndham Florence 10/10 Excellent "Very nice" [](https://expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) ![Staybridge Suites Florence - Civic Center by IHG](//images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/5abcf1ed_y.jpg) ### Staybridge Suites Florence - Civic Center by IHG 10/10 Excellent "Everything excellent from the staff to the food." [](https://expedia.ca/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information) ![Park Inn by Radisson Florence, SC](//images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg) ### Park Inn by Radisson Florence, SC 10/10 Excellent "The front desk person was welcoming, professional and very kind." [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Howard Johnson by Wyndham Florence](//images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "💯" [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Aloft Florence](//images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/0724af0f_y.jpg) ### Aloft Florence 10/10 Excellent "they were great! " [](https://expedia.ca/Florence-Hotels-Aloft-Florence.h76026194.Hotel-Information) ![Comfort Inn & Suites](//images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites 10/10 Excellent "Friendly staff, clean, comfortable room." [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Residence Inn Marriott Florence](//images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb_y.jpg) ### Residence Inn Marriott Florence 10/10 Excellent "Nice room and easy in and out. " [](https://expedia.ca/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) ![Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG](//images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31_y.jpg) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG 10/10 Excellent "The staff was wonderful " [](https://expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![TownePlace Suites by Marriott Florence](//images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg) ### TownePlace Suites by Marriott Florence 10/10 Excellent "Friendly staff. Clean hotel." [](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ## Find out more about Pamplico ## Pamplico Vacation Homes information | Number of reviews | 111 | | --- | --- | | Accommodation | 27 Vacation Homes | | Lowest Price | CA $251 | | Highest Price | CA $836 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [5 Star Hotels in Florence](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Aparthotels in Aynor](https://www.expedia.ca/Aynor-Apart-Hotels.d3000353082-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Aynor](https://www.expedia.ca/Aynor-Bed-And-Breakfast.d3000353082-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Aynor](https://www.expedia.ca/Aynor-Cabins.d3000353082-aaCabins.Travel-Guide-Accommodation) - [Coward Hotels](https://www.expedia.ca/Coward-Hotels.d3000353109.Travel-Guide-Hotels) - [Cheap Hotels in Florence County](https://www.expedia.ca/Destinations-In-Florence-County-Cheap-Hotels.0-0-d553248635976432658-tCheapHotels.Hotel-Filter-Destinations) - 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