Title: 10 Best Hotels in Otay Mesa West, San Diego for 2025 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa West Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa-West.d553248625809641010.Car-Rental-Guide)[Otay Mesa West Vacations](https://expedia.ca/Otay-Mesa-West.d553248625809641010.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Hotels in Otay Mesa West, San Diego ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Otay Mesa West Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&lodging=APART_HOTEL) Resort [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&lodging=HOTEL_RESORT) Spa [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&amenities=SPA_ON_SITE) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&travelerType=family_friendly) Pool [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&amenities=POOL) Ocean view [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&amenities=OCEAN_VIEW) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&lodging=APARTMENT) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&amenities=HOT_TUB) Condo [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&lodging=CONDO) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&lodging=COTTAGE) Villa [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&lodging=VILLA) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa+West%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=553248625809641010&latLong=32.577585%2C-117.054421&adults=2&startDate=2025-10-19&d1=2025-10-19&endDate=2025-10-21&d2=2025-10-21&amenities=WATER_PARK) ## Check prices for these dates Tonight [Oct 5 - Oct 6](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-05&endDate=2025-10-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-06&endDate=2025-10-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Otay Mesa West hotels and places to stay ![Rooftop terrace](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/a314a493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/881441d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/dd3cca67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palihotel San Diego Gaslamp Quarter Gaslamp Quarter, 18.1 km from Otay Mesa West 8.8/10 Excellent (1883) "A lovely hotel, great staff. I will definitely stay here again. " CA $157 CA $182 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/43298e98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/f7c3fa7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/b435bca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/038c4b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada Suites by Wyndham San Diego/Hotel Circle Area 22.8 km from Otay Mesa West 6.2/10 (1015) "Clean room, friendly staff" CA $106 CA $121 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/San-Diego-Hotels-Ramada-Suites-By-Wyndham-San-Diego.h11553.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100830000/100828000/100827985/60078fd7_edited_a626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Billiards](https://images.trvl-media.com/lodging/101000000/100830000/100828000/100827985/a01039da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Elite Suite, 1 Queen Bed, Kitchenette](https://images.trvl-media.com/lodging/101000000/100830000/100828000/100827985/7ea5ffe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite, 2 Bedrooms](https://images.trvl-media.com/lodging/101000000/100830000/100828000/100827985/b99cbba6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zindel Little Italy, 19.6 km from Otay Mesa West 7.6/10 Good (550) "Nice place and you could walk to most places of interest " CA $97 CA $145 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/San-Diego-Hotels-Hotel-Zindel.h100827985.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/88f9cd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/5142b853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/d5ea2f3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside 19.2 km from Otay Mesa West 8.4/10 Very good (5964) "Great stay near the airport." CA $212 CA $287 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/91baa1e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/ade03197.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/8bb8fc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Marina Gateway Hotel 10.5 km from Otay Mesa West 9.2/10 Wonderful (3301) "Great hotel" CA $187 CA $206 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Serves dinner and happy hour](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/ce3fee83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/d9883b91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/93444558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/c6debcd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Horton Grand, Downtown/Gaslamp Quarter 17.8 km from Otay Mesa West 9.0/10 Wonderful (2589) "Great location and lovely staff. " CA $186 CA $253 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/San-Diego-Hotels-The-Horton-Grand.h11026.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a0a6825c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/49bcb235.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a9bcd444.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/e3befa7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter Gaslamp Quarter, 17.6 km from Otay Mesa West 9.0/10 Wonderful (1149) "Great stay! " CA $236 CA $274 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-DowntownGaslamp-Quarter.h2918129.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/4877ef6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/7bb755a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/1194fa32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/3a963240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Cordova Hotel on Coronado Island 16.4 km from Otay Mesa West 8.8/10 Excellent (1004) "Cute and unique hotel!" CA $250 CA $317 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Coronado-Hotels-El-Cordova-Hotel-On-Coronado-Island.h11395.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/54935ba5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/ddc5f050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, City View (1 Queen and 1 Sofabed) | Living area](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/3de76bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/23c18b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gaslamp Plaza Suites Gaslamp Quarter, 18.2 km from Otay Mesa West 8.8/10 Excellent (1007) "Had a great stay " CA $151 CA $171 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/San-Diego-Hotels-Gaslamp-Plaza-Suites.h16266.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/23e38216.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/d85ecd0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/7e147d0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hard Rock Hotel San Diego Gaslamp Quarter, 17.5 km from Otay Mesa West 9.0/10 Wonderful (2984) "Loved staying here. Will definitely stay again " CA $250 CA $354 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/5feb0059.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/30e922d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking (Mobility/Hearing Impaired) | Bathroom](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/a4925138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/7a33c92c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham El Cajon/San Diego 26.2 km from Otay Mesa West 7.8/10 Good (1003) "Great place " CA $97 CA $107 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/El-Cajon-Hotels-Super-8-By-Wyndham-El-Cajon-CA.h4926.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/75ec9582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/589f8e80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/f8b10da9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Sofia Hotel 18.5 km from Otay Mesa West 8.4/10 Very good (1597) "Close to a lot of areas, would stay here again." CA $139 CA $195 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Standard Room, 1 King Bed, Smoking](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/2b01136a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/81f394e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/e71b90b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Smoking](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/1e9b6911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham San Diego-East/El Cajon 27 km from Otay Mesa West 7.6/10 Good (1004) "Place was nice and comfy. Decent stay at a very genuine price. " CA $110 CA $121 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/El-Cajon-Hotels-Days-Inn-By-Wyndham-San-Diego-EastEl-Cajon.h1175963.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2540b7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/423e7241.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/99024d06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loews Coronado Bay Resort 9.7 km from Otay Mesa West 8.8/10 Excellent (1039) "Beautiful quiet hotel." CA $278 CA $372 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/aa7dcb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/bb4bfc7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/2639daee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/965cd455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus La Mesa San Diego 23.2 km from Otay Mesa West 8.2/10 Very good (1004) "Excelent place to stay." CA $138 CA $152 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/La-Mesa-Hotels-Best-Western-Plus-La-Mesa-San-Diego.h20454.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/243b93bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/8f3ed06e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds (Fab)](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/febc9a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/d154e491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bristol Hotel San Diego 18.5 km from Otay Mesa West 8.6/10 Excellent (1389) "Very nice staff from check in, clean rooms, quiet and comfortable. " CA $190 CA $221 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-The-Bristol-Hotel-San-Diego.h23816.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/fe340c37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/7012e279.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/0c67e9c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/bd7d0518.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Chula Vista/San Diego 7.2 km from Otay Mesa West 6.2/10 (1007) "The staff was incredibly helpful" CA $100 CA $110 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Chula-Vista-Hotels-Red-Roof-Inn-PLUS-Chula-Vista.h2217787.Hotel-Information) ![Premium bedding, pillowtop beds, desk, blackout drapes](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/c31e05e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/53d75480.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/1fbe17de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/ec632047.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staypineapple, Hotel Z, Gaslamp San Diego Gaslamp Quarter, 17.8 km from Otay Mesa West 9.4/10 Exceptional (1001) "Great staff and clean rooms" CA $208 CA $281 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/San-Diego-Hotels-Staypineapple.h11486063.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/236157bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/dc860349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/w395h595x4y3-183171c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/e45ffdb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Pensione Hotel Little Italy, 19.4 km from Otay Mesa West 8.6/10 Excellent (1868) "Great place to stay they are right in the middle of everything " CA $187 CA $213 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/San-Diego-Hotels-La-Pensione-Hotel.h914373.Hotel-Information) ![Panoramic Room](https://images.trvl-media.com/lodging/38000000/37230000/37226900/37226869/90c3821a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/38000000/37230000/37226900/37226869/34c93ca7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Room | Living area](https://images.trvl-media.com/lodging/38000000/37230000/37226900/37226869/w846h1124x2y0-931d900a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Room | Living area](https://images.trvl-media.com/lodging/38000000/37230000/37226900/37226869/9049d715.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Abpopa Hillcrest Hillcrest, 21.3 km from Otay Mesa West 8.2/10 Very good (520) "Great place" CA $144 CA $162 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/San-Diego-Hotels-Abpopa-Hillcrest.h37226869.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-20&endDate=2025-10-21®ionId=553248625809641010&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in Otay Mesa West Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. - Downtown San Diego - Gaslamp Quarter - Pacific Beach - Mission Beach - Ocean Beach ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481093-Downtown-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480742-Maritime-Museum-Of-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476416-Downtown-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480743-Maritime-Museum-Of-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476415-Downtown-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=800123) ![Downtown San Diego map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:yfwfEzeejUaMaj%40fa%40k%5CbLaPx%40qOkGcWu%40i%5B%60DgKrIcFdRgF%7CrAsAHjJvK%60IqKjOFzR%7EP%7CI%7BH%7CO%7CIfNma%40hn%40%7B%40fIe%5ChZma%40t%40o%40kSei%40E_FfEiEnLwEd%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Cs9sAV_TcaQK48f0iT1-t86hPRE=) ### Downtown San Diego Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options. [See properties](https://www.expedia.ca/Hotel-Search?regionId=800123) ![Gaslamp Quarter showing street scenes, night scenes and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22037-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/475000/475881-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480435-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480422-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480432-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6130021) ![Gaslamp Quarter map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mmtfEh%7CbjUAwJqIDCm%5B%60x%40OmEpJ%7DPD%40zAiE%40A_B%7BEBFj%5B_HH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=68cMX7ldk9-J6tcepLMBQKKwvpY=) ### Gaslamp Quarter Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6130021) ![Pacific Beach Park showing a sandy beach](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152283-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park which includes rugged coastline, a coastal town and surfing](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152049-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park featuring a sandy beach and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152293-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park featuring a beach](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152300-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park which includes a beach bar and drinks or beverages](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152301-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6185751) ![Pacific Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:agfgEvyujUgHcNcG%60IiBwN%7BKtBkf%40inCoKyIyEoFcHy%40aKoT%60mBq_B%7Cl%40aZb%40xB%7DAlAuMdQsExHkAvMbB%7CVpV_F%7CGrk%40tPgDhDlTbMbDlZu%40%60V%7EDxQfMtAlJg%40xH_GxEkRnGkUrA%7DP%60IiFbTv%40lR%60J%7CNcKjBzCfUec%40%60L%7BUxIkP%60IuM%7CH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=5FbBeekgWkepp0jnCE7WEy_Qh88=) ### Pacific Beach Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6185751) ![Belmont Park which includes a garden and rides](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22160-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Belmont Park featuring street scenes and rides as well as a large group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22159-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Belmont Park which includes a city, rides and street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22161-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/187000/187064-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Belmont Park ![Belmont Park](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/187000/187072-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Belmont Park [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635998112279) ![Mission Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ec%7DfE%7CgujU_Die%40%7BAYqk%40sBclAvBeNh%40wNtAcg%40%60H_DqUxGwAlD%7EF%60Dm%40v%40%40Bb%40tDIhRqFnGs%40nEBzOdBzF%40xI%7DAvNwH%60BMfBZt%40m%40EhIzJy%40hNJI%7DIrBvAjErA%7EJb%40%7CMcEjJsFzArBfF%7EcA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=hFrZWtAC8u-2IGYk_Bcs7ztzP5Q=) ### Mission Beach Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635998112279) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481019-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480252-San-Diego-City.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481012-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481011-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481016-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=177689) ![Ocean Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:eq%7CfEneujUqO%7ByCl%5CdMdL%7B%40pnB%60%60BoUlb%40crB%60I&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=lCc_uj9JIfh1kP738Xl1bJJqo_A=) ### Ocean Beach Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego. [See properties](https://www.expedia.ca/Hotel-Search?regionId=177689) ## Top Otay Mesa West Hotel Reviews ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Stay was excellent room always cleaned and beds made promptly. Room was very spacious and view of the bay with balcony amazing. Location is excellent." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Hotel is pretty and is in a great location to be able to walk to shops, restaurants and bars " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "It was centrally located,. I had private car and they had parking in. It was perfect for me, the rooms were comfortable and clean. Pretty view." [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean room" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Thanks " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Clean room, friendly staff " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Had a comfortable stay" [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "We stayed for 9 nights and had an awesome time! Staff was friendly and accommodating. " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Great ocean view located right on wide beach. Hotel is awesome." [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ## Frequently asked questions ### What are the best family hotels in Otay Mesa West? > The [Best Western Chula Vista/Otay Valley Hotel](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) is an excellent choice for families seeking a comfortable and convenient stay. This hotel offers a refreshing pool area, superb for kids to splash around while parents relax nearby. The property also provides cribs at no extra charge, making it easy for families traveling with infants. Guests appreciate the daily housekeeping service that keeps everything tidy, along with microwaves in the rooms, ensuring you can prepare quick snacks for your little ones. > > > > Another family-friendly option is the [Motel 6 San Diego, CA - Southbay](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h663151.Hotel-Information). This hotel is particularly accommodating for families with children, offering connecting rooms, which allow for easy supervision and bonding time. Young travellers can enjoy free stays, adding great value for families on a budget. Like the Best Western, this property also features housekeeping services and microwaves, making it convenient for families to settle in and feel at home. ### What hotels in Otay Mesa West offer free breakfast? > The [Best Western Chula Vista/Otay Valley Hotel](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) is a fantastic choice for travellers seeking comfort and convenience in Otay Mesa West. This hotel offers a delightful start to your day with a complimentary continental breakfast, ensuring you and your family can fuel up before heading out on your adventures. ### What are the best budget hotels in Otay Mesa West? > The [Best Western Chula Vista/Otay Valley Hotel](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) is a fantastic budget-friendly option in Otay Mesa West, offering families and travellers a comfortable stay with a variety of amenities. Guests appreciate the outdoor pool, great for splashing around after a day of exploration, and the complimentary continental breakfast ensures a great start to your day without breaking the bank. > > > > This hotel also caters to families, providing free cribs and accessible parking, making it easy for parents traveling with young children. The fitness centre allows adults to stay active, while free WiFi keeps everyone connected. With a customer review rating of 7.8, it's clear that many have found it to be a reliable choice for quality and convenience. ### Can I cancel my hotel reservation on Expedia? > You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Otay Mesa West. ### How can I save on a Otay Mesa West hotel booking with Expedia? > With Expedia, you'll unlock our lowest prices by becoming a member. It's free and easy to join, and you can even access member perks too. Just remember to sign in to get our best prices on Otay Mesa West hotels. Another way to save is by booking your hotel and flights together on Expedia, where bundling can lead to significant savings. ### How much is the nightly rate at a Otay Mesa West hotel? > Hotel prices in Otay Mesa West often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. 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[Aparthotels in San Diego](https://expedia.ca/San-Diego-Apart-Hotels.d3073-aaApartHotels.Travel-Guide-Accommodation) - [Resorts in San Diego](https://expedia.ca/San-Diego-Resort-Hotels.d3073-aaResortHotels.Travel-Guide-Accommodation) - [Motels in San Diego](https://expedia.ca/San-Diego-Motels.d3073-aaMotels.Travel-Guide-Accommodation) - [Hostels in San Diego](https://expedia.ca/San-Diego-Hostels.d3073-aaHostels.Travel-Guide-Accommodation) - [B&B in San Diego](https://expedia.ca/San-Diego-Bed-And-Breakfast.d3073-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Houseboats in San Diego](https://expedia.ca/San-Diego-Houseboats.d3073-aaHouseboats.Travel-Guide-Accommodation) - [Inns in San Diego](https://expedia.ca/San-Diego-Inns.d3073-aaInns.Travel-Guide-Accommodation) - [Farmstay in San Diego](https://expedia.ca/San-Diego-Agritourism.d3073-aaAgritourism.Travel-Guide-Accommodation) - [Cabin Rentals in San Diego](https://expedia.ca/San-Diego-Cabins.d3073-aaCabins.Travel-Guide-Accommodation) - [RV Parks in San Diego](https://expedia.ca/San-Diego-RV-Parks.d3073-aaRVParks.Travel-Guide-Accommodation) - [Condo Resorts in San Diego](https://expedia.ca/San-Diego-Condominium-Resort.d3073-aaCondominiumResort.Travel-Guide-Accommodation) - [Residences in San Diego](https://expedia.ca/San-Diego-Residences.d3073-aaResidences.Travel-Guide-Accommodation) ### Hotels Close to Nearby Airports - [Hotels near San Diego Intl. Airport](https://expedia.ca/San-Diego-Intl-Airport-Hotels.0-aSAN-0.Travel-Guide-Filter-Hotels) - [Hotels near Brown Field Municipal Airport](https://expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Hotels near Montgomery Field Airport](https://expedia.ca/Montgomery-Field-Airport-Hotels.0-aMYF-0.Travel-Guide-Filter-Hotels) - [Hotels near Gillespie Field Airport](https://expedia.ca/Gillespie-Field-Airport-Hotels.0-aSEE-0.Travel-Guide-Filter-Hotels) - [Hotels near McClellan-Palomar Airport](https://expedia.ca/McClellan-Palomar-Airport-Hotels.0-aCLD-0.Travel-Guide-Filter-Hotels) ### Otay Mesa West Hotels by Star Rating - [2 Star Hotels in Otay Mesa West](https://expedia.ca/2Star-Otay-Mesa-West-San-Diego-Hotels.s20-n553248625809641010-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Otay Mesa West](https://expedia.ca/3Star-Otay-Mesa-West-San-Diego-Hotels.s30-n553248625809641010-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Otay Mesa West](https://expedia.ca/4Star-Otay-Mesa-West-San-Diego-Hotels.s40-n553248625809641010-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Otay Mesa West](https://expedia.ca/5Star-Otay-Mesa-West-San-Diego-Hotels.s50-n553248625809641010-0.Travel-Guide-Filter-Hotels) ### Otay Mesa West Hotels by Brand - [Bartell Hotels Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Bartell-Hotels.0-n553248625809641010-0--bBartellHotels.Travel-Guide-Filter-Hotels) - [Best Western Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Best-Western.0-n553248625809641010-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Hilton Hotels Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Hilton-Hotels.0-n553248625809641010-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Independent Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Independent.0-n553248625809641010-0--bIndependent.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-La-Quinta-Inn-Suites.0-n553248625809641010-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Marriott-Hotels-Resorts.0-n553248625809641010-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Motel-6.0-n553248625809641010-0--bMotel6.Travel-Guide-Filter-Hotels) - [Noble House Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Noble-House.0-n553248625809641010-0--bNobleHouse.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Wyndham-Extra-Holidays.0-n553248625809641010-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Wyndham Hotels Hotels](https://expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Wyndham-Hotels.0-n553248625809641010-0--bWyndhamHotels.Travel-Guide-Filter-Hotels) ### Explore more hotels - [Kings Inn San Diego](https://expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) - [The Little Italy Hotel Downtown San Diego](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) - [Hilton San Diego Mission Valley](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) - [Hotel del Coronado, Curio Collection by Hilton](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) - [Pendry San Diego](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) - [Bay Club Hotel & Marina](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) - [The Sofia Hotel](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) - [Legacy Resort Hotel & Spa](https://expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) - [Marriott Marquis San Diego Marina](https://expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) - [Sheraton San Diego Resort](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) - [California Suites Hotel](https://expedia.ca/San-Diego-Hotels-California-Suites-Hotel.h40531.Hotel-Information) - [Hyatt Regency Mission Bay Spa and Marina](https://expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) [See a list of all hotels in San Diego](https://expedia.ca/All-San-Diego-Hotels.d3073.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Otay Mesa West on Expedia.com](https://www.expedia.com/Otay-Mesa-West-San-Diego-Hotels.0-n553248625809641010-0.Travel-Guide-Filter-Hotels) ### Expedia's Latest Trends Hotels - [Hotels in Ocean Beach](https://expedia.ca/Ocean-Beach-San-Diego-Hotels.0-n177689-0.Travel-Guide-Filter-Hotels) - [Hotels in Koreatown](https://expedia.ca/Koreatown-Los-Angeles-Hotels.0-n6156068-0.Travel-Guide-Filter-Hotels) - [Hotels in Union Square](https://expedia.ca/Union-Square-San-Francisco-Hotels.0-n800129-0.Travel-Guide-Filter-Hotels) - [Hotels in Downtown San Diego](https://expedia.ca/Downtown-San-Diego-San-Diego-Hotels.0-n800123-0.Travel-Guide-Filter-Hotels) - [Hotels in Downtown San Francisco](https://expedia.ca/Downtown-San-Francisco-San-Francisco-Hotels.0-n6151902-0.Travel-Guide-Filter-Hotels) - [Hotels in Pacific Beach](https://expedia.ca/Pacific-Beach-San-Diego-Hotels.0-n6185751-0.Travel-Guide-Filter-Hotels) - [Hotels in Mission Valley](https://expedia.ca/Mission-Valley-San-Diego-Hotels.0-n800124-0.Travel-Guide-Filter-Hotels) - 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