Title: Book the Best Otay Mesa West WINERY Hotels in 2025 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa West Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa-West.d553248625809641010.Car-Rental-Guide)[Otay Mesa West Vacations](https://expedia.ca/Otay-Mesa-West.d553248625809641010.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/c82ea711c1af69b78661e7f0e8d60f0e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Leonardo De Leon # Find Winery Hotels in Otay Mesa West, CA from CA $110 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa West Winery Hotels Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-14&endDate=2025-10-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Otay Mesa West Winery Hotels ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 outdoor pools, a heated pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/d0f041ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/a9d5662a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/7fe47de0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Paradise Point Resort & Spa San Diego 8.6/10 Excellent (2303) "Great spot right on the bay, Been there forever which is part of the charm." CA $217 CA $320 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/a90f2d6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/18bcfb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/58b6effd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/14f93e35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 Suites San Ysidro, CA -San Diego South Bay San Ysidro 7.8/10 Good (1299) "Ideally located " CA $97 CA $110 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/San-Ysidro-Hotels-Studio-6-Suites-San-Ysidro.h1798071.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/12000000/11990000/11981200/11981154/39135f25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Kitchen](https://images.trvl-media.com/lodging/12000000/11990000/11981200/11981154/d7e34a22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms | Living area](https://images.trvl-media.com/lodging/12000000/11990000/11981200/11981154/39433261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/12000000/11990000/11981200/11981154/e8b14ece.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Sunset Cliffs Ocean Beach 9.2/10 Wonderful (1007) "Great quiet peaceful place to stay" CA $280 CA $316 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/San-Diego-Hotels-The-Inn-At-Sunset-Cliffs.h11981154.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21200/21135/5c5f8e88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed, Balcony, Bay View](https://images.trvl-media.com/lodging/1000000/30000/21200/21135/c18834b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed, Balcony, Bay View](https://images.trvl-media.com/lodging/1000000/30000/21200/21135/ea338056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/21200/21135/dd9a437a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin San Diego Gaslamp Quarter Downtown San Diego 8.8/10 Excellent (1010) "Clean room, friendly staff" CA $263 CA $346 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-The-Westin-San-Diego-Gaslamp-Quarter.h21135.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/338bb608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/27f733a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/2312739a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking (View)](https://images.trvl-media.com/lodging/1000000/330000/327500/327441/dfc0f891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Downtown Downtown San Diego 8.8/10 Excellent (1005) "Great stay!" CA $255 CA $296 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Downtown.h327441.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/3b915004.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking (Balcony)](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/139a6c49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/76ddbc07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/0f34ec95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel by Marriott San Diego Downtown Gaslamp Quarter Downtown San Diego 8.8/10 Excellent (934) "Would definitely stay again!" CA $238 CA $276 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Diego-Hotels-AC-Hotel-By-Marriott-San-Diego-Downtown-Gaslamp-Quarter.h87137975.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119490000/119481800/119481708/59c0f3d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119490000/119481800/119481708/4e86a830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119490000/119481800/119481708/2908b87f_edited_9fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/120000000/119490000/119481800/119481708/fb0cda9c_edited_cf3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3BR - 3Bth near San Diego Gaslamp Beach National City 10/10 Exceptional (1) "Being a San Diego native, the location was perfect. It was centrally located between both mine and my partners jobs, as well as being within 20 minutes of everything SD has to offer. The living room AC took some getting used to, as the display for the remote was broken, however it worked as normal. It got a bit loud at times, but I attribute it to being the one AC trying to cool down a large room. Nonetheless, there were so many windows and you're technically on the third floor, so opening the... CA $77 CA $392 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/National-City-Hotels-Modern-3-Bed-3-Bath-Near-San-Diego-Gaslamp-Beach.h119481708.Hotel-Information) ![Sun loungers, beach towels](https://images.trvl-media.com/lodging/102000000/101390000/101388900/101388878/0046ec42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/102000000/101390000/101388900/101388878/c507452e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/102000000/101390000/101388900/101388878/9e04083f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/101390000/101388900/101388878/02623002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 1 block from ocean - stylish & cozy beach cottage in funky Ocean Beach! Ocean Beach 9.6/10 Exceptional (33) "Location was perfect. The rental was clean and perfectly sized for the two of us." CA $159 CA $518 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/San-Diego-Hotels-1-Block-From-Ocean-Stylish-Cozy-Beach-Cottage-In-Funky-Ocean-Beach.h101388878.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/9000000/8790000/8782500/8782409/da8f2406.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Library](https://images.trvl-media.com/lodging/9000000/8790000/8782500/8782409/f6cdb0c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/9000000/8790000/8782500/8782409/6d6bdbe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed (Wedgewood) | Living area](https://images.trvl-media.com/lodging/9000000/8790000/8782500/8782409/6988f242.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vineyard Hacienda Spring Valley 9.2/10 Wonderful (525) "Beautiful place, kind staff. We are glad we found this place!" CA $228 CA $247 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Spring-Valley-Hotels-Vineyard-Hacienda.h8782409.Hotel-Information) ![Smart TV, books, music library](https://images.trvl-media.com/lodging/119000000/118010000/118006200/118006148/54f471e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/119000000/118010000/118006200/118006148/f6e25af1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118010000/118006200/118006148/b5e925b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/119000000/118010000/118006200/118006148/ac23292f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3BR/2Bth Mountain View, 2500 sqft, King Bed, Garage Jamul 10/10 Exceptional (1) CA $180 CA $511 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Jamul-Hotels-Charming-3-Bedroom-House-With-WiFi.h118006148.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. 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