Title: Hotels by Omni in Otay Mesa West from CA $361 | Expedia.ca [Otay Mesa West Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa-West.dx553248625809641010)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa West Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa-West.d553248625809641010.Car-Rental-Guide)[Otay Mesa West Vacations](https://expedia.ca/Otay-Mesa-West.d553248625809641010.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/c82ea711c1af69b78661e7f0e8d60f0e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Leonardo De Leon # Find Hotels by Omni in Otay Mesa West from CA $361 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-11-02&endDate=2025-11-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-11-03&endDate=2025-11-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Otay Mesa West Omni Hotels ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/a9075ad6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/169b339e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 5:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/7806cdf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Bay View (Spacious, King Bed) | View from room](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/8cc93949.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni San Diego Hotel at the Ballpark Downtown San Diego 9.2/10 Wonderful (2059) "Professional staff, great hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ryan CA $257 CA $361 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-Omni-San-Diego-Hotel.h982408.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-16&endDate=2025-11-17®ionId=553248625809641010&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-West-San-Diego-Hotels-Omni.0-n553248625809641010-0--bOmni.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-West-San-Diego-Hotels-Omni.0-n553248625809641010-0--bOmni.Travel-Guide-Filter-Hotels) ## Top Otay Mesa West Hotel Reviews ![Hampton Inn & Suites by Hilton San Diego SeaWorld](//images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Good people " [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Everyone was incredibly nice great job" [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Good service, room was clean. " [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "I don’t know where to start. From the shuttle in to the shuttle out, everything was perfect!" [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Courtyard by Marriott San Diego Downtown Little Italy](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Balcony view and healthy breakfast! Excellent customer service!" [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Comfort Inn Sea World Area](//images.trvl-media.com/lodging/1000000/550000/544700/544662/44f458a2_y.jpg) ### Comfort Inn Sea World Area 10/10 Excellent "Vlwan" [](https://expedia.ca/San-Diego-Hotels-Comfort-Inn-Sea-World-Area.h544662.Hotel-Information) ![Wyndham Garden San Diego Near SeaWorld](//images.trvl-media.com/lodging/1000000/50000/41000/40962/76b78879_y.jpg) ### Wyndham Garden San Diego Near SeaWorld 10/10 Excellent "The staff were friendly. The room was clean but there were some issues in the room. Shower head was not completely sealed. There there spots on the ceiling in the bathroom and the some baseboards were messed up. " [](https://expedia.ca/San-Diego-Hotels-Wyndham-Garden-San-Diego-Near-SeaWorld.h40962.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "An excellent classic beachfront hotel. We have visited the property for several years, but this is the first time that we stayed in the hotel. It lived up to all of our expectations. Located on the famous Coronado Beach, the hotel offers six different dining alternatives, each maintaining a distinctive focus and personality. Loved Nobu in particular. Nice shops. Amazing beach!!" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "standard room, only thing we kind of have issues with was our key wasn't working properly when leaving the parking, so we would just press on the call button then they'll eventually open the gate." [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ## Find out more about Otay Mesa West ## Otay Mesa West Hotels Guide Expedia.ca offers a selection of 6788 hotels in Otay Mesa West. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Otay Mesa West. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Otay Mesa West neighborhood you prefer. Go ahead. 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