Title: Book the Best Otay Mesa West LUXURY Hotels - Upscale Hotels in Otay Mesa West, San Diego | Expedia.ca

  

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# Find Luxury Hotels in Otay Mesa West, San Diego

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## Check availability on Otay Mesa West Luxury Hotels

Tonight

[Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-13&endDate=2025-10-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-14&endDate=2025-10-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Otay Mesa West Luxury Hotels

## Top Otay Mesa West Hotel Reviews

![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg)

### The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent

"I really liked this place, it is quiet, clean and is located in a nice place, the only think I didn't like is that I had to pay $35 to use the parking lot."

[](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information)

![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg)

### Best Western Plus Marina Gateway Hotel

10/10 Excellent

"The hotel is clean and relaxing. The staff is courteous and always eager to accommodate. The best part was the coffee machine in the lobby. I'll be returning. "

[](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information)

![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg)

### Wyndham San Diego Bayside

10/10 Excellent

"Great that there is an airport shuttle. Very convenient to cruise terminal."

[](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information)

![Days Inn by Wyndham San Diego Hotel Circle](//images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg)

### Days Inn by Wyndham San Diego Hotel Circle

10/10 Excellent

"Location, price amazing! Friendly staff"

[](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information)

![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg)

### Hotel del Coronado, Curio Collection by Hilton

10/10 Excellent

"Amazing property "

[](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information)

![Kings Inn San Diego](//images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg)

### Kings Inn San Diego

10/10 Excellent

"Pleasant stay"

[](https://expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information)

![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg)

### Hard Rock Hotel San Diego

10/10 Excellent

"Very clean, easy to move a lot things to do and Tourist Really love it"

[](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information)

![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg)

### Sheraton San Diego Resort

10/10 Excellent

"Amazing"

[](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information)

![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg)

### The Sofia Hotel

10/10 Excellent

"Great location for the gaslamp"

[](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information)

## Frequently asked questions

### Are you searching for the perfect hotel for your luxury holiday in Otay Mesa West?

> Expedia can help you get a flight to Tijuana Intl. Airport (TIJ) airport or San Diego Intl. Airport (SAN) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Otay Mesa West has to offer.

### What's there to see and do in Otay Mesa West?

> Experience Otay Mesa West and visit San Diego Zoo, Mission Bay, and San Ysidro Border Crossing. If you have extra time while you're in the area, you might want to see Hotel del Coronado and Petco Park.

### How can I get around Otay Mesa West?

> It's easier to get around town comfortably when you know your options. Make your way to Iris Avenue Trolley Station for metro transit.

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