Title: Hotels by Best Western in Otay Mesa West from CA $122 | Expedia.ca [Otay Mesa West Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa-West.dx553248625809641010)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa West Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa-West.d553248625809641010.Car-Rental-Guide)[Otay Mesa West Vacations](https://expedia.ca/Otay-Mesa-West.d553248625809641010.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 28 - Jan 29](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2026-01-28&endDate=2026-01-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 29 - Jan 30](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2026-01-29&endDate=2026-01-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248625809641010&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa West Best Western ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/297b9804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/e17b5b7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/0303dbfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/6bd68dda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Inn & Suites San Diego – Zoo/SeaWorld Area [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) Mission Valley 8.0/10 Very good (2,406 reviews) "Nice hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lamberto Jr CA $136 CA $156 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/e24122f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-6971afdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-2f0f89f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Seven Seas [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) Mission Valley 8.0/10 Very good (3,174 reviews) "The place and room was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Trinidad CA $106 CA $122 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/bc7617fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ad23cf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/5a519562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/ddddbc6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Chula Vista/Otay Valley Hotel [](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) Otay 7.8/10 Good (1,590 reviews) "Clean rooms and the breakfast was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vanessa CA $143 CA $158 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/025fd645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/e40d2481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/2ba90811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/bb54a734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Americana Inn [](https://www.expedia.ca/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) San Ysidro 8.8/10 Excellent (1,218 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elisa CA $149 CA $170 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking, Microwave](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/08f46b14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/3a81799d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/02dbf386.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/6a4d216d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Yacht Harbor Hotel [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) Point Loma 8.6/10 Excellent (1,698 reviews) "Great rate for a great stay!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) James CA $155 CA $178 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-498f6208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-a1a1fa40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/a137d768.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-a0181fa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western San Diego Pacific Beach/Mission Bay [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-Diego-Pacific-BeachMission-Bay.h18147.Hotel-Information) Bay Park 8.4/10 Very good (252 reviews) "Clean hotel & great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) yardley CA $126 CA $145 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-Diego-Pacific-BeachMission-Bay.h18147.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/1954ac96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Kitchenette (with Sofabed)](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/e868665c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/w3840h2560x0y1-a53682c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/3bd865c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Santee Lodge [](https://www.expedia.ca/Santee-Hotels-Best-Western-Santee-Lodge.h27004.Hotel-Information) Santee 7.8/10 Good (603 reviews) " Room was clean and the staff was friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $153 CA $168 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Santee-Hotels-Best-Western-Santee-Lodge.h27004.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/8edd50b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/c3b7953f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/3ce0d724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking, Refrigerator](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/6b4abe60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Downtown San Diego [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Cabrillo-Garden-Inn.h973615.Hotel-Information) Downtown San Diego 8.4/10 Very good (931 reviews) "Very clean the room and nice place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marisol CA $185 CA $211 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Cabrillo-Garden-Inn.h973615.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-12&endDate=2026-02-13®ionId=553248625809641010&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-West-San-Diego-Hotels-Best-Western.0-n553248625809641010-0--bBestWestern.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-West-San-Diego-Hotels-Best-Western.0-n553248625809641010-0--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Otay Mesa West Hotel Reviews ![Courtyard by Marriott San Diego Downtown Little Italy](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "The room was clean and the staff was very welcoming " [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "Great stay. Wonderful location " [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Great little spot, also very. close to Little Italy farmers market. The staff was very friendly and accommodating. if need a place for a quick get a way this is it. " [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Sentral Gaslamp Quarter](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/b82a5191_y.jpg) ### Sentral Gaslamp Quarter 10/10 Excellent "Sentral has been a great find for me and my puppy. Staff is extremely friendly and helpful. I have everything I need in the suite." [](https://expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Clean room, comfortable bed and pillow. Spacious and updated." [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "staff were friendly and accommodating." [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg) ### Paradise Point Resort & Spa 10/10 Excellent "Clean. Great location. Hidden treasure. Heated pools. " [](https://expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Nice" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Great stay! " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ## Find out more about Otay Mesa West ## Otay Mesa West Hotels Guide Expedia.ca offers a selection of 6899 hotels in Otay Mesa West. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Otay Mesa West. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Otay Mesa West neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Otay Mesa West, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [Bartell Hotels in Barrio Logan ](https://www.expedia.ca/Barrio-Logan-San-Diego-Hotels-Bartell-Hotels.0-n553248635976388733-0--bBartellHotels.Travel-Guide-Filter-Hotels) - [Hotels near Beyer Blvd Trolley Station ](https://www.expedia.ca/Beyer-Blvd-Trolley-Station-Hotels.d6186828.Travel-Guide-Hotels) - [La Quinta Inn & Suites Hotels in Bonita ](https://www.expedia.ca/Bonita-Hotels-La-Quinta-Inn-Suites.0-0-d177687--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Camino Real Hotels in Castle Park ](https://www.expedia.ca/Castle-Park-Chula-Vista-Hotels-Camino-Real.0-n177686-0--bCaminoReal.Travel-Guide-Filter-Hotels) - [Accor Hotels in Chula Vista ](https://www.expedia.ca/Chula-Vista-Hotels-Accor-Hotels.0-0-d7442--bAccorHotels.Travel-Guide-Filter-Hotels) - [Extended Stay America Hotels in Chula Vista ](https://www.expedia.ca/Chula-Vista-Hotels-Extended-Stay-America.0-0-d7442--bExtendedStayAmerica.Travel-Guide-Filter-Hotels) - 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