Title: Hotels by Motel 6 in Otay Mesa from CA $99 | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 23 - Jan 24](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-23&endDate=2026-01-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 24 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-24&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa Motel 6 ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/79d129c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/b2dde816.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/59ede676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/19df6caa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Ysidro, CA - San Diego - Border [](https://www.expedia.ca/San-Ysidro-Hotels-Motel-6-San-Ysidro.h57235.Hotel-Information) San Ysidro 7.0/10 Good (1,487 reviews) "The staff seemed nice but the restrooms could have used cleaning " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leticia CA $97 CA $110 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/San-Ysidro-Hotels-Motel-6-San-Ysidro.h57235.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/f71452c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/4e3a5f44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/5bf5b920.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/63e66623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 El Cajon, CA - San Diego [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) El Cajon 7.4/10 Good (1,506 reviews) "We only stayed one night but it was comfortable and clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandy CA $90 CA $99 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/28a65c4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/52b5d02a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/75f70bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/95f9de7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Chula Vista, CA - San Diego [](https://www.expedia.ca/Chula-Vista-Hotels-Motel-6-Chula-Vista.h996139.Hotel-Information) Chula Vista 6.0/10 (1,737 reviews) "Awesome staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria CA $89 CA $102 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Chula-Vista-Hotels-Motel-6-Chula-Vista.h996139.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/bbc30b9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/5ac30f2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Double Room, 1 Queen Bed, Non Smoking, Refrigerator | Bathroom](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/edba2136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee and/or coffee maker](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/ece30776.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego, CA - Downtown [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h979323.Hotel-Information) Downtown San Diego 6.2/10 (1,241 reviews) "very nice staff, hotel, and location. Get there early to secure parking. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Saquib CA $85 CA $101 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h979323.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/e1f8ca63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/aeb52f58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/0cdeeab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/383ad103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego, CA - Hotel Circle - Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h996099.Hotel-Information) Mission Valley 6.8/10 (1,476 reviews) "Quick and easy check in, room was clean, spacious. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lizbeth CA $103 CA $118 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h996099.Hotel-Information) ![Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/3eadc536.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/ea596309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/5adc58b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/eac85e21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego Airport - Harbor [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego-Airport-Harbor.h13147064.Hotel-Information) Downtown San Diego 7.2/10 Good (1,005 reviews) "Clean room, friendly staff and proximity the airport. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margaret CA $100 CA $114 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego-Airport-Harbor.h13147064.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/340dbfd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/57452eba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/b8558e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, towels](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/dfda8053.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego, CA - Southbay [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h663151.Hotel-Information) Nestor 7.4/10 Good (1,005 reviews) "Clean and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lillian CA $99 CA $111 total includes taxes & fees Feb 11 - Feb 12 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h663151.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/f857bc80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/811fde23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/2565e8b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/46653e76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 La Mesa, CA [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h565024.Hotel-Information) La Mesa 7.2/10 Good (1,005 reviews) "Very nice room. No shampoo but soap was good. Close to hospital." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Betsy [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h565024.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/abdecda1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/81089cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/afc27f05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/58fd0de7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 La Mesa, CA - San Diego [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h998968.Hotel-Information) La Mesa 7.4/10 Good (991 reviews) "Excellent service" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Luay CA $124 CA $137 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h998968.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-07&endDate=2026-02-08®ionId=6263723&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Motel-6.0-n6263723-0--bMotel6.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Motel-6.0-n6263723-0--bMotel6.Travel-Guide-Filter-Hotels) ## Top Otay Mesa Hotel Reviews ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Outstanding " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Sofia Hotel](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Clean, nice friendly staff" [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Pendry San Diego](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Good hotel " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Sentral Gaslamp Quarter](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/b82a5191_y.jpg) ### Sentral Gaslamp Quarter 10/10 Excellent "Staff is very nice " [](https://expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Outstanding service we loved it and will go back again. " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "The bed was noiceeeee" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Clean" [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "The riom was great, staff was very friendly, lots of things to do in and around the hotel." [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Perfect stay — highly recommend. A near-new hotel with spotless, modern rooms in a very convenient location. The beds were incredibly comfortable, making it easy to relax and unwind. The breakfast buffet was a real highlight — especially the Hampton waffles, which were absolutely delicious. The facilities were well maintained and enjoyable, with a warm pool and hot tub that we loved using. The staff were exceptionally friendly and helpful throughout our stay. A massive shout-out to Malarie, who went above and beyond to make our experience truly superb and accommodating. Thank you so much 🤗🙏" [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ## Find out more about Otay Mesa ## Otay Mesa Hotels Guide Expedia.ca offers a selection of 4889 hotels in Otay Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Otay Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Otay Mesa neighborhood you prefer. Go ahead. 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