Title: Hotels by Motel 6 in Otay Mesa from CA $92 | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Feb 2 - Feb 3](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-02&endDate=2026-02-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 3 - Feb 4](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-03&endDate=2026-02-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa Motel 6 ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/23d13d0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/12575691.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/a024d7fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/57300/57235/126585af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Ysidro, CA - San Diego - Border [](https://www.expedia.ca/San-Ysidro-Hotels-Motel-6-San-Ysidro.h57235.Hotel-Information) San Ysidro 7.2/10 Good (1,482 reviews) "Easy acces to restsurant" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JOSE CA $89 CA $101 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Ysidro-Hotels-Motel-6-San-Ysidro.h57235.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/3bc75d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/83d682ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/be50f5c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/fb684d7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 El Cajon, CA - San Diego [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) El Cajon 7.4/10 Good (1,508 reviews) "We only stayed one night but it was comfortable and clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandy CA $84 CA $93 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/49d692f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/46e3fb07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/49113a9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/996200/996139/453e1d9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Chula Vista, CA - San Diego [](https://www.expedia.ca/Chula-Vista-Hotels-Motel-6-Chula-Vista.h996139.Hotel-Information) Chula Vista 6.0/10 (1,726 reviews) "Awesome staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria CA $80 CA $92 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Chula-Vista-Hotels-Motel-6-Chula-Vista.h996139.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/bbc30b9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee and/or coffee maker](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/ece30776.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/5ac30f2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Double Room, 1 Queen Bed, Non Smoking, Refrigerator | Bathroom](https://images.trvl-media.com/lodging/1000000/980000/979400/979323/edba2136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego, CA - Downtown [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h979323.Hotel-Information) Downtown San Diego 6.2/10 (1,236 reviews) "very nice staff, hotel, and location. Get there early to secure parking. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Saquib CA $80 CA $99 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h979323.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/e1f8ca63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/09242ddc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/4f31ca7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/1000000/996100/996099/9bccaa72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego, CA - Hotel Circle - Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h996099.Hotel-Information) Mission Valley 6.8/10 (1,466 reviews) "Quick and easy check in, room was clean, spacious. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lizbeth CA $95 CA $109 total includes taxes & fees Feb 4 - Feb 5 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h996099.Hotel-Information) ![Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/0e2b836a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/a2df9b05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/fdac2751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/14000000/13150000/13147100/13147064/2d566cbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego Airport - Harbor [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego-Airport-Harbor.h13147064.Hotel-Information) Downtown San Diego 7.2/10 Good (1,008 reviews) "Clean room, friendly staff and proximity the airport. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margaret CA $111 CA $127 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego-Airport-Harbor.h13147064.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/975c5305.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, towels](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/df442bab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/5b5c059d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/670000/663200/663151/aad9fb53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Diego, CA - Southbay [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h663151.Hotel-Information) Nestor 7.4/10 Good (1,001 reviews) "Clean and friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lillian CA $109 CA $122 total includes taxes & fees Feb 10 - Feb 11 [](https://www.expedia.ca/San-Diego-Hotels-Motel-6-San-Diego.h663151.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/879c7f28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/be7ed53f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/ef7518eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/570000/565100/565024/106443b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 La Mesa, CA [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h565024.Hotel-Information) La Mesa 7.2/10 Good (1,002 reviews) "Very nice room. No shampoo but soap was good. Close to hospital." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Betsy [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h565024.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/6d417f12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/58fd0de7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/54c6fac8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/1000000/999000/998968/0ea1345d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 La Mesa, CA - San Diego [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h998968.Hotel-Information) La Mesa 7.4/10 Good (991 reviews) "Excellent service" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Luay CA $115 CA $127 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/La-Mesa-Hotels-Motel-6-La-Mesa.h998968.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-17&endDate=2026-02-18®ionId=6263723&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Motel-6.0-n6263723-0--bMotel6.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Motel-6.0-n6263723-0--bMotel6.Travel-Guide-Filter-Hotels) ## Top Otay Mesa Hotel Reviews ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "This place was really nice and cozy. Friendly staff. The only thing I didn’t like was we had to pay $35 per car for parking. " [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Always fabulous! That’s a great staff here, the views are wonderful, the restaurant is great, the bar is fun and the bartenders are wonderful. There’s the sweetest lady in the mornings that helps with breakfast and her name is Mariam and she is the best. I always love my stay here. " [](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "I really enjoy staying here when in San Diego. What a relaxing place. I'm afforded the opportunity to contemplate and reflect when I'm here.. it's very rewarding and the accomodations are well above par. " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Room was clean and staff was outstanding." [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Staff was helpful" [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Everything excellent but expensive" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Rooms were very accommodating and clean and good size. The staff were helpful and friendly. I highly recommend staying here " [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Was a comfortable Room. Shower tile looked pretty run down. But otherwise was a excellent place to stay before cruise." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg) ### Paradise Point Resort & Spa 10/10 Excellent "Always a good time" [](https://expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ## Find out more about Otay Mesa ## Otay Mesa Hotels Guide Expedia.ca offers a selection of 4908 hotels in Otay Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Otay Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Otay Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Otay Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [Hilton Hotels in Altadena ](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Bartell Hotels in Barrio Logan ](https://www.expedia.ca/Barrio-Logan-San-Diego-Hotels-Bartell-Hotels.0-n553248635976388733-0--bBartellHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Bonita ](https://www.expedia.ca/Bonita-Hotels-La-Quinta-Inn-Suites.0-0-d177687--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Hotels near Brown Field Municipal ](https://www.expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Casa de Oro-Mount Helix ](https://www.expedia.ca/Casa-De-Oro-Mount-Helix-Hotels-Wyndham-Extra-Holidays.0-0-d553248635975875970--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - 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