Title: Book the Best Otay Mesa LUXURY Hotels - Upscale Hotels in Otay Mesa, San Diego | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Otay Mesa, San Diego - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa Luxury Hotels Tonight [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-11-05&endDate=2025-11-06&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 6 - Nov 7](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-11-06&endDate=2025-11-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Otay Mesa Luxury Hotels ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/673df2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/d3d09d7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa Otay Mesa 7.2/10 Good (1005) "Hotel was great the staff was very attentive. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anibal CA $126 CA $143 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-19&endDate=2025-11-20®ionId=6263723&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Otay Mesa Hotel Reviews ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Amazing! " [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "The room and service was excellent. " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Clean room, friendly staff, and great service." [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Sheraton Mission Valley San Diego Hotel](//images.trvl-media.com/lodging/1000000/20000/11800/11725/f387ad25_y.jpg) ### Sheraton Mission Valley San Diego Hotel 10/10 Excellent "Everything was great!!" [](https://expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) ![Comfort Inn Sea World Area](//images.trvl-media.com/lodging/1000000/550000/544700/544662/44f458a2_y.jpg) ### Comfort Inn Sea World Area 10/10 Excellent "Very clean rooms and very accessible. Loved it." [](https://expedia.ca/San-Diego-Hotels-Comfort-Inn-Sea-World-Area.h544662.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Airport shuttle was the best. Rooms are ok with nice views. " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Beautiful location and loved the pools." [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Great room and great staff! They really made our stay with their hospitality and efficiency. " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Loews Coronado Bay Resort](//images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864_y.jpg) ### Loews Coronado Bay Resort 10/10 Excellent "Beautiful hotel. The room was clean, quiet, and had a great view. The staff was excellent. The only complaint was the price of parking. 50 a day. We would definitely stay there again. " [](https://expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ## Frequently asked questions ### Are you searching for the perfect hotel for your luxury getaway to Otay Mesa? > Use Expedia to arrange your flight to Tijuana Intl. Airport (TIJ) airport or San Diego Intl. Airport (SAN) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a vacation, so we make it easy to get what you want to make your stay special. If you want a posh hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Otay Mesa has to offer. During your visit, you might want to enjoy the restaurants which Otay Mesa is known for. ### What's there to see and do in Otay Mesa? > Enjoy Otay Mesa and visit San Diego Zoo, San Ysidro Border Crossing, and Hotel del Coronado. 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