Title: Hotels by Independent in Otay Mesa from CA $87 | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 18 - Jan 19](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-18&endDate=2026-01-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 19 - Jan 20](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-19&endDate=2026-01-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa Independent ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/b0a789a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/9eb7273b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/a24a0e44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bay Club Hotel & Marina [](https://www.expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) Point Loma 9.2/10 Wonderful (3,295 reviews) "Beautiful location, great staff, always a pleasure to stay here" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) simona CA $174 CA $200 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/981f9667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed (High Floor)](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/3d7acad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) Mission Valley 9.2/10 Wonderful (2,933 reviews) "Great relaxing hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher CA $248 CA $285 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![3 bars/lounges, lobby lounge, cocktail bar, cocktail bar](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/ce2dc6d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/abbee14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/fd80224d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, minibar, desk](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/8ea4f9d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) University Heights 9.4/10 Exceptional (1,420 reviews) "Nice staff, very clean, good food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) TIM CA $319 CA $366 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/08ee83c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/8c0b3f94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/aa651342.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves lunch and dinner](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/7680d8f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Hotel San Diego Gaslamp Quarter [](https://www.expedia.ca/San-Diego-Hotels-Solamar-San-Diego.h1117693.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1,199 reviews) "Perfect location in the Gaslamp District. Rooms were large & clean with friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ginger CA $259 CA $357 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/San-Diego-Hotels-Solamar-San-Diego.h1117693.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/90271416.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/a98dc1ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/b67130be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2210000/2202800/2202716/9ad1416a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Inn San Diego [](https://www.expedia.ca/San-Diego-Hotels-Heritage-Inn-San-Diego-Near-SeaWorld.h2202716.Hotel-Information) Point Loma 7.4/10 Good (1,212 reviews) "Clean, safe, kinda walkable, but really good for the prices " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darius CA $83 CA $96 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/San-Diego-Hotels-Heritage-Inn-San-Diego-Near-SeaWorld.h2202716.Hotel-Information) ![5 outdoor pools, a heated pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/d0f041ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed (Bayside Bungalow Bay) | Living area](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/2fecbf54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/7fe47de0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Paradise Point Resort & Spa [](https://www.expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) Mission Bay 8.6/10 Excellent (2,369 reviews) "Great facility and amenities. We look forward to taking our family back again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andy CA $194 CA $296 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![2 outdoor pools, a heated pool, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/8e8c5197.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/9248247c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/0673c619.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/2c4c818b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Dana on Mission Bay [](https://www.expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) Mission Bay 9.0/10 Wonderful (3,996 reviews) "We had a wonderful stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Megan CA $221 CA $286 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/14000000/13160000/13155700/13155645/b95fa76e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Birthday party area](https://images.trvl-media.com/lodging/14000000/13160000/13155700/13155645/be7e10d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/14000000/13160000/13155700/13155645/da997a05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hot springs](https://images.trvl-media.com/lodging/14000000/13160000/13155700/13155645/61eaf52a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Atwood Hotel San Diego - SeaWorld/Zoo [](https://www.expedia.ca/San-Diego-Hotels-The-Atwood.h13155645.Hotel-Information) Mission Valley 8.0/10 Very good (1,860 reviews) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle [](https://www.expedia.ca/San-Diego-Hotels-The-Atwood.h13155645.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/879bd035.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/8c83985c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Spa](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/d5d4acc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/3000000/2820000/2811100/2811010/8cf8ea27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Inn La Mesa [](https://www.expedia.ca/La-Mesa-Hotels-Heritage-Inn-La-Mesa.h2811010.Hotel-Information) La Mesa 7.0/10 Good (1,252 reviews) "room was clean and staff very friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles CA $79 CA $87 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/La-Mesa-Hotels-Heritage-Inn-La-Mesa.h2811010.Hotel-Information) ![Breakfast, lunch, dinner served; Mediterranean cuisine ](https://images.trvl-media.com/lodging/1000000/20000/18300/18241/1b98f5a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Bay View (Marina Suite King 2nd Floor) | Dock](https://images.trvl-media.com/lodging/1000000/20000/18300/18241/9090f3e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/1000000/20000/18300/18241/794c3bf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden view](https://images.trvl-media.com/lodging/1000000/20000/18300/18241/a9901fbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bahia Resort Hotel [](https://www.expedia.ca/San-Diego-Hotels-Bahia-Resort-Hotel.h18241.Hotel-Information) Central Mission Beach 8.6/10 Excellent (1,845 reviews) "Front desk was very helpful when checking in " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly CA $224 CA $334 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/San-Diego-Hotels-Bahia-Resort-Hotel.h18241.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-01&endDate=2026-02-02®ionId=6263723&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Independent.0-n6263723-0--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Independent.0-n6263723-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Otay Mesa Hotel Reviews ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Great location. Nice property on the bay." [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Geat and good " [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Pendry San Diego](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Well decorated, super clean high touches " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Everything was very clean, and the staff were very professional but friendly " [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "My stay was great, room was beautiful and we had breakfast which was actually pretty good. " [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![San Diego Mission Bay Resort](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d_y.jpg) ### San Diego Mission Bay Resort 10/10 Excellent "The staff was great,service was excellent! " [](https://expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) ![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Room was clean, Hotel was in a great location to areas we wanted to visit, staff was courteous and was able to resolve issues with gate quickly" [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Sentral Gaslamp Quarter](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/b82a5191_y.jpg) ### Sentral Gaslamp Quarter 10/10 Excellent "Everything from the great hospitality to the innovative technology. I've never heard of a washer and dryer combined into one machine! I was able to do my laundry in my room. Never been able to do that before. It was so cool 😎" [](https://expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Very nice room" [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ## Find out more about Otay Mesa ## Otay Mesa Hotels Guide Expedia.ca offers a selection of 4905 hotels in Otay Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Otay Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Otay Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Otay Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [Hilton Hotels in Altadena ](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Bartell Hotels in Barrio Logan ](https://www.expedia.ca/Barrio-Logan-San-Diego-Hotels-Bartell-Hotels.0-n553248635976388733-0--bBartellHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Bonita ](https://www.expedia.ca/Bonita-Hotels-La-Quinta-Inn-Suites.0-0-d177687--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Hotels near Brown Field Municipal ](https://www.expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Casa de Oro-Mount Helix ](https://www.expedia.ca/Casa-De-Oro-Mount-Helix-Hotels-Wyndham-Extra-Holidays.0-0-d553248635975875970--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - 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