Title: Hotels by Independent in Otay Mesa | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 16 - Mar 17](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-03-16&endDate=2026-03-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 17 - Mar 18](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-03-17&endDate=2026-03-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Independent.0-n6263723-0--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Independent.0-n6263723-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Otay Mesa Hotel Reviews ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/7e147d0f_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean clean clean!" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Bahia Resort Hotel](https://images.trvl-media.com/lodging/1000000/20000/18300/18241/1b98f5a3_y.jpg) ### Bahia Resort Hotel 6/10 Okay "Rooms are dated, clean. Great location and staff and had everything we needed. " [](https://expedia.ca/San-Diego-Hotels-Bahia-Resort-Hotel.h18241.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/4003f7ef_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "The staff is incredible. So attentive & kind. They go out of their way to be helpful. The property is spotless and they clearly have pride in how the hotel is maintained. My significant other left behind a piece of durable medical equipment. The staff was so helpful in retrieving it. The views and the location can't be beat. Stunning from many angles. I can't say enough good things but mostly it is the staff that brought us back 2x's within the same month. " [](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![San Diego Mission Bay Resort](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/b5f2a64d_y.jpg) ### San Diego Mission Bay Resort 6/10 Okay "Nice family friendly resort. Outdoor pool and common areas really nice, and good for all ages." [](https://expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/8e8c5197_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "We enjoyed our stay and the staff were very helpful " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/8cec183d_y.jpg) ### Handlery Hotel 10/10 Excellent "Pool was fantastic the staff absolutely amazing " [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 8/10 Good "Expensive parking!" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 6/10 Okay "Room is worn but reasonably clean and comfortable. Grateful that A/C works. bottled water cost money, no kettle or tea/coffee." [](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/a77f85c3_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "The room was really comfortable, in the perfect location, and with easy to access/secure parking. The pool area was clean and safe, and everyone was very friendly. " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ## Find out more about Otay Mesa ## Otay Mesa Hotels Guide Expedia.ca offers a selection of 4868 hotels in Otay Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Otay Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Otay Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Otay Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [Hilton Hotels in Altadena ](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Bartell Hotels in Barrio Logan ](https://www.expedia.ca/Barrio-Logan-San-Diego-Hotels-Bartell-Hotels.0-n553248635976388733-0--bBartellHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Bonita ](https://www.expedia.ca/Bonita-Hotels-La-Quinta-Inn-Suites.0-0-d177687--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Hotels near Brown Field Municipal ](https://www.expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Casa de Oro-Mount Helix ](https://www.expedia.ca/Casa-De-Oro-Mount-Helix-Hotels-Wyndham-Extra-Holidays.0-0-d553248635975875970--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - 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Airport (EWR) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/ewr/sdm/newark-liberty-intl-airport-to-san-diego) - [Flights from Fresno (FAT) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/fat/sdm/fresno-to-san-diego) - [Flights from Sierra Vista (FHU) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/fhu/sdm/sierra-vista-to-san-diego) - [Flights from Fort Lauderdale (FLL) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/fll/sdm/fort-lauderdale-to-san-diego) - [Flights from Hong Kong (HKG) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/hkg/sdm/hong-kong-to-san-diego) - [Flights from Hayward (HWD) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/hwd/sdm/hayward-to-san-diego) - [Flights from Houston (IAH) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/iah/sdm/houston-to-san-diego) - [Flights from Jacksonville (JAX) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/jax/sdm/jacksonville-to-san-diego) - [Flights from Las Vegas (LAS) to San Diego (SDM) ](https://www.expedia.ca/lp/flights/las/sdm/las-vegas-to-san-diego) - 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