Title: Book the Best Otay Mesa Hotels with smoking rooms in 2025 from CA $158 | Expedia.ca

  

[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides)

![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find Smoking Hotels in Otay Mesa, San Diego from CA $158

![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)

### 

Change your mind

Book hotels with free cancellation

![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)

### 

Treat yourself

Sign in to save 10% or more on thousands of hotels

[Sign in](https://www.expedia.ca/login)

![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)

### 

Be picky

Search almost a million properties worldwide

## Check availability on Otay Mesa Hotels with smoking rooms

Tonight

[Sep 30 - Oct 1](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-09-30&endDate=2025-10-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 1 - Oct 2](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-01&endDate=2025-10-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Otay Mesa Hotels with smoking rooms

![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/eda7e8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/3f975189.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Accessible, Non Smoking (Mobility, Transfer Shower)](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1d234b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Otay Mesa

8.0/10

Very good

(1467)

"Very good to stayed "

CA $139

CA $158 total

includes taxes & fees

Oct 7 - Oct 8

[](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-15&endDate=2025-10-16&regionId=6263723&adults=2&property_amenities_group_explore=designated_smoking_areas&sort=RECOMMENDED&openPlayBack=true)

## Top Otay Mesa Hotel Reviews

![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg)

### The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent

"Rooms are clean. Nice staff"

[](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information)

![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg)

### The Dana on Mission Bay

10/10 Excellent

"good "

[](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information)

![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg)

### Sheraton San Diego Resort

10/10 Excellent

"Excellent service in the front desk from Hamilton. Help me to get a great room."

[](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information)

## Explore a world of travel with Expedia

-   Lodging
-   More ways to book

-   [Beach Hotel Hotels in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Early Check-in in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotel-With-Early-Check-In.0-0-d6068523-thotelwithearlycheckin.Travel-Guide-Filter-Hotels)
-   [Hotels with an Indoor Pool in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotels-With-Indoor-Pool.0-0-d6068523-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Luxury-Hotel.0-0-d6068523-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Oceanfront Hotels in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Oceanfront-Hotels.0-0-d6068523-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
-   [Ski Hotels in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Ski-Hotel.0-0-d6068523-tSkiHotel.Travel-Guide-Filter-Hotels)
-   [Hotels & Resorts for Couples in Carlsbad](https://www.expedia.ca/Carlsbad-Hotels-Couples-Resorts-Hotels.0-0-d6056550-tCouplesResortsHotels.Travel-Guide-Filter-Hotels)
-   [Hotels with Early Check-in in Carlsbad](https://www.expedia.ca/Carlsbad-Hotels-Hotel-With-Early-Check-In.0-0-d6056550-thotelwithearlycheckin.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Carlsbad](https://www.expedia.ca/Carlsbad-Hotels-Hotels-With-Hot-Tubs.0-0-d6056550-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Lake Hotels in Carlsbad](https://www.expedia.ca/Carlsbad-Hotels-Lake-Hotels.0-0-d6056550-tLakeHotels.Travel-Guide-Filter-Hotels)
-   [Scuba Diving Hotels in Carlsbad](https://www.expedia.ca/Carlsbad-Hotels-Scuba-Diving-Vacations.0-0-d6056550-tscubadivingvacations.Travel-Guide-Filter-Hotels)
-   [Winery Hotels in Carlsbad](https://www.expedia.ca/Carlsbad-Hotels-Winery-Hotel.0-0-d6056550-tWineryHotel.Travel-Guide-Filter-Hotels)
-   [Casino Hotels in Chula Vista](https://www.expedia.ca/Chula-Vista-Hotels-Casino-Hotel.0-0-d7442-tCasinoHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Chula Vista](https://www.expedia.ca/Chula-Vista-Hotels-Hotels-With-Hot-Tubs.0-0-d7442-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Chula Vista](https://www.expedia.ca/Chula-Vista-Hotels-Spa-Hotel.0-0-d7442-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Green Hotels in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Green-Sustainable.0-0-d178304-tGreenSustainable.Hotel-Filter-Destinations)
-   [Hotels with Wifi in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Hotel-With-Wifi.0-0-d178304-tHotelwithwifi.Hotel-Filter-Destinations)
-   [Hotels with Bar in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Hotels-With-Bar.0-0-d178304-tHotelswithBar.Hotel-Filter-Destinations)
-   [Hotels with Childcare in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Hotels-With-Childcare.0-0-d178304-tHotelswithChildcare.Hotel-Filter-Destinations)
-   [Hotels with Free Breakfast in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Hotels-With-Free-Breakfast.0-0-d178304-tHotelswithFreeBreakfast.Hotel-Filter-Destinations)
-   [Hotels with Free Parking in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Hotels-With-Free-Parking.0-0-d178304-tHotelswithFreeParking.Hotel-Filter-Destinations)
-   [Hotels with Hot Tubs in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Hotels-With-Hot-Tubs.0-0-d178304-tHotelsWithHotTubs.Hotel-Filter-Destinations)
-   [Hotels with smoking rooms in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Hotels-With-Smoking-Rooms.0-0-d178304-tHotelswithsmokingrooms.Hotel-Filter-Destinations)
-   [Lgbt Friendly Hotels in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-LGBT-Friendly-Hotel.0-0-d178304-tLGBTFriendlyHotel.Hotel-Filter-Destinations)
-   [Scuba Diving Hotels in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Scuba-Diving-Vacations.0-0-d178304-tscubadivingvacations.Hotel-Filter-Destinations)
-   [Shopping Hotels in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Shopping-Hotel.0-0-d178304-tShoppingHotel.Hotel-Filter-Destinations)
-   [Hotel Wedding Venues Hotels in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Wedding-Hotels.0-0-d178304-tWeddingHotels.Hotel-Filter-Destinations)
-   [Adults Only Resorts & in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Adults-Only-Resorts.0-n800123-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
-   [Hotels & Resorts for Couples in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Couples-Resorts-Hotels.0-n800123-0-tCouplesResortsHotels.Travel-Guide-Filter-Hotels)
-   [Golf Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Golf-Hotel.0-n800123-0-tGolfHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Wifi in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Hotel-With-Wifi.0-n800123-0-tHotelwithwifi.Travel-Guide-Filter-Hotels)
-   [Hotels with a Lazy River in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Hotels-With-A-Lazy-River.0-n800123-0-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels)
-   [Hotels with Balconies in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Hotels-With-Balconies.0-n800123-0-tHotelswithBalconies.Travel-Guide-Filter-Hotels)
-   [Hotels with Bar in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Hotels-With-Bar.0-n800123-0-tHotelswithBar.Travel-Guide-Filter-Hotels)
-   [Hotels with Free Breakfast in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Hotels-With-Free-Breakfast.0-n800123-0-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Hotels-With-Hot-Tubs.0-n800123-0-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Hotels with an Indoor Pool in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Hotels-With-Indoor-Pool.0-n800123-0-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
-   [Lgbt Friendly Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-LGBT-Friendly-Hotel.0-n800123-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Lake Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Lake-Hotels.0-n800123-0-tLakeHotels.Travel-Guide-Filter-Hotels)
-   [Mountain Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Mountain-Hotels.0-n800123-0-tMountainHotels.Travel-Guide-Filter-Hotels)
-   [Romantic Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Romantic-Hotel.0-n800123-0-tRomanticHotel.Travel-Guide-Filter-Hotels)
-   [Scuba Diving Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Scuba-Diving-Vacations.0-n800123-0-tscubadivingvacations.Travel-Guide-Filter-Hotels)
-   [Shopping Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Shopping-Hotel.0-n800123-0-tShoppingHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Spa-Hotel.0-n800123-0-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Waterpark Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Waterpark-Hotels.0-n800123-0-tWaterparkHotels.Travel-Guide-Filter-Hotels)
-   [Winery Hotels in Downtown San Diego](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels-Winery-Hotel.0-n800123-0-tWineryHotel.Travel-Guide-Filter-Hotels)
-   [Green Hotels in Gaslamp Quarter](https://www.expedia.ca/Gaslamp-Quarter-San-Diego-Hotels-Green-Sustainable.0-n6130021-0-tGreenSustainable.Travel-Guide-Filter-Hotels)
-   [Hotels with Bar in Gaslamp Quarter](https://www.expedia.ca/Gaslamp-Quarter-San-Diego-Hotels-Hotels-With-Bar.0-n6130021-0-tHotelswithBar.Travel-Guide-Filter-Hotels)
-   [Waterpark Hotels in Gaslamp Quarter](https://www.expedia.ca/Gaslamp-Quarter-San-Diego-Hotels-Waterpark-Hotels.0-n6130021-0-tWaterparkHotels.Travel-Guide-Filter-Hotels)
-   [Scuba Diving Hotels in Laguna Beach](https://www.expedia.ca/Laguna-Beach-Hotels-Scuba-Diving-Vacations.0-0-d8384-tscubadivingvacations.Travel-Guide-Filter-Hotels)
-   [All Inclusive Resorts and in Ocean View Hills](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels-All-Inclusive-Hotel.0-n553248635976008220-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
-   [Beach Hotel Hotels in Ocean View Hills](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels-Beach-Hotel.0-n553248635976008220-0-tBeachHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Early Check-in in Ocean View Hills](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels-Hotel-With-Early-Check-In.0-n553248635976008220-0-thotelwithearlycheckin.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Ocean View Hills](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels-Hotels-With-Hot-Tubs.0-n553248635976008220-0-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Mountain Hotels in Ocean View Hills](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels-Mountain-Hotels.0-n553248635976008220-0-tMountainHotels.Travel-Guide-Filter-Hotels)
-   [Oceanfront Hotels in Ocean View Hills](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels-Oceanfront-Hotels.0-n553248635976008220-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
-   [Hotel Wedding Venues Hotels in Ocean View Hills](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels-Wedding-Hotels.0-n553248635976008220-0-tWeddingHotels.Travel-Guide-Filter-Hotels)
-   [Historic Hotels in Oceanside](https://www.expedia.ca/Oceanside-Hotels-Historic-Hotel.0-0-d9154-tHistoricHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Balconies in Oceanside](https://www.expedia.ca/Oceanside-Hotels-Hotels-With-Balconies.0-0-d9154-tHotelswithBalconies.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Oceanside](https://www.expedia.ca/Oceanside-Hotels-Hotels-With-Hot-Tubs.0-0-d9154-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in Otay Mesa West](https://www.expedia.ca/Otay-Mesa-West-San-Diego-Hotels-Cheap-Hotels.0-n553248625809641010-0-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Lgbt Friendly Hotels in Otay Ranch Village 1](https://www.expedia.ca/Otay-Ranch-Village-1-Chula-Vista-Hotels-LGBT-Friendly-Hotel.0-n553248635976473906-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Lgbt Friendly Hotels in Otay Ranch Village West](https://www.expedia.ca/Otay-Ranch-Village-West-Chula-Vista-Hotels-LGBT-Friendly-Hotel.0-n553248635976473051-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in San Diego Coast](https://www.expedia.ca/San-Diego-Coast-Hotels-Cheap-Hotels.0-0-d553248633966884021-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Family Hotels in San Diego Coast](https://www.expedia.ca/San-Diego-Coast-Hotels-Family-Hotel.0-0-d553248633966884021-tFamilyHotel.Travel-Guide-Filter-Hotels)
-   [Green Hotels in San Diego Coast](https://www.expedia.ca/San-Diego-Coast-Hotels-Green-Sustainable.0-0-d553248633966884021-tGreenSustainable.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in San Diego Coast](https://www.expedia.ca/San-Diego-Coast-Hotels-Hotels-With-Hot-Tubs.0-0-d553248633966884021-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Lake Hotels in San Diego Coast](https://www.expedia.ca/San-Diego-Coast-Hotels-Lake-Hotels.0-0-d553248633966884021-tLakeHotels.Travel-Guide-Filter-Hotels)
-   [Business Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Business-Hotel.0-0-d3073-tBusinessHotel.Travel-Guide-Filter-Hotels)
-   [Casino Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Casino-Hotel.0-0-d3073-tCasinoHotel.Travel-Guide-Filter-Hotels)
-   [Hotels & Resorts for Couples in San Diego](https://www.expedia.ca/San-Diego-Hotels-Couples-Resorts-Hotels.0-0-d3073-tCouplesResortsHotels.Travel-Guide-Filter-Hotels)
-   [Golf Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Golf-Hotel.0-0-d3073-tGolfHotel.Travel-Guide-Filter-Hotels)
-   [Green Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Green-Sustainable.0-0-d3073-tGreenSustainable.Travel-Guide-Filter-Hotels)
-   [Historic Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Historic-Hotel.0-0-d3073-tHistoricHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Wifi in San Diego](https://www.expedia.ca/San-Diego-Hotels-Hotel-With-Wifi.0-0-d3073-tHotelwithwifi.Travel-Guide-Filter-Hotels)
-   [Hotels with Bar in San Diego](https://www.expedia.ca/San-Diego-Hotels-Hotels-With-Bar.0-0-d3073-tHotelswithBar.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in San Diego](https://www.expedia.ca/San-Diego-Hotels-Hotels-With-Hot-Tubs.0-0-d3073-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Lake Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Lake-Hotels.0-0-d3073-tLakeHotels.Travel-Guide-Filter-Hotels)
-   [Scuba Diving Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Scuba-Diving-Vacations.0-0-d3073-tscubadivingvacations.Travel-Guide-Filter-Hotels)
-   [Hotel Wedding Venues Hotels in San Diego](https://www.expedia.ca/San-Diego-Hotels-Wedding-Hotels.0-0-d3073-tWeddingHotels.Travel-Guide-Filter-Hotels)
-   [Boutique Hotels in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Boutique-Hotel.0-0-d8380-tBoutiqueHotel.Travel-Guide-Filter-Hotels)
-   [Business Hotels in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Business-Hotel.0-0-d8380-tBusinessHotel.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Cheap-Hotels.0-0-d8380-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Hotels & Resorts for Couples in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Couples-Resorts-Hotels.0-0-d8380-tCouplesResortsHotels.Travel-Guide-Filter-Hotels)
-   [Hotels with Early Check-in in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Hotel-With-Early-Check-In.0-0-d8380-thotelwithearlycheckin.Travel-Guide-Filter-Hotels)
-   [Hotels with Free Airport Shuttle in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d8380-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Luxury-Hotel.0-0-d8380-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Pet-Friendly-Hotel.0-0-d8380-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Winery Hotels in San Ysidro](https://www.expedia.ca/San-Ysidro-Hotels-Winery-Hotel.0-0-d8380-tWineryHotel.Travel-Guide-Filter-Hotels)
-   [All Inclusive Resorts and in South Bay](https://www.expedia.ca/South-Bay-Hotels-All-Inclusive-Hotel.0-0-d6056572-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
-   [Beach Hotel Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Beach-Hotel.0-0-d6056572-tBeachHotel.Travel-Guide-Filter-Hotels)
-   [Boutique Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Boutique-Hotel.0-0-d6056572-tBoutiqueHotel.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Cheap-Hotels.0-0-d6056572-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Golf Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Golf-Hotel.0-0-d6056572-tGolfHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Kitchenettes in South Bay](https://www.expedia.ca/South-Bay-Hotels-Hotels-With-Kitchenettes.0-0-d6056572-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Luxury-Hotel.0-0-d6056572-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Oceanfront Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Oceanfront-Hotels.0-0-d6056572-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Pet-Friendly-Hotel.0-0-d6056572-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Spa-Hotel.0-0-d6056572-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Winery Hotels in South Bay](https://www.expedia.ca/South-Bay-Hotels-Winery-Hotel.0-0-d6056572-tWineryHotel.Travel-Guide-Filter-Hotels)

-   [Book Hotels in Otay Mesa on Expedia.com](https://www.expedia.com/Otay-Mesa-San-Diego-Hotels-Hotels-With-Smoking-Rooms.0-n6263723-0-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)