Title: Book the Best Otay Mesa FAMILY FRIENDLY Hotels from CA $99 - Kid-Friendly Hotels in Otay Mesa, San Diego | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa Family Hotels Tonight [Jan 26 - Jan 27](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-26&endDate=2026-01-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Tomorrow [Jan 27 - Jan 28](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-27&endDate=2026-01-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) ## Our top choices for Otay Mesa family-friendly hotels ![Free on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/bd6623c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/70282182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa [](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) Otay Mesa 7.2/10 Good (1,006 reviews) "The room was nice the beds comfortable I’ll stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leo CA $136 CA $154 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/322e8dd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/e79ecd34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/b4dcb6f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/71485688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza San Diego - Mission Valley by IHG [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) Mission Valley 8.0/10 Very good (1,031 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Viviann CA $133 CA $153 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Corner](https://images.trvl-media.com/lodging/1000000/10000/900/858/721ac3a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/10000/900/858/c095adf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) Mission Bay 8.4/10 Very good (1,596 reviews) "Balcony view is awesome, clean room, staff at counter and restaurant service was stunning." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) francisco CA $218 CA $323 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, Bay View](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1e0934c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1a09735e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/3eeea039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (974 reviews) "Clean rooms and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Topeka CA $170 CA $197 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c4fd269e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/05a7ba66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/d6929efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loews Coronado Bay Resort [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) Silver Strand 8.8/10 Excellent (1,074 reviews) "Clean room, gorgeous grounds, very friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Taryn CA $259 CA $354 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/f71452c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/a653b43a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/4e3a5f44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/63e66623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 El Cajon, CA - San Diego [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) El Cajon 7.4/10 Good (1,507 reviews) "We only stayed one night but it was comfortable and clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandy CA $90 CA $99 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/14800/14745/99067de2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 9:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/14800/14745/41b93b2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14800/14745/9fc7cd11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/14800/14745/ddc24aab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn San Diego Old Town [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-San-Diego-Old-Town.h14745.Hotel-Information) Old Town San Diego 8.2/10 Very good (1,946 reviews) "Rooms are very clean, workers were very friendly. Will definitely stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Claudia CA $139 CA $160 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-San-Diego-Old-Town.h14745.Hotel-Information) ![2 restaurants, dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/26148b25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/10909e43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/bf074aa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/9d67384d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kings Inn San Diego [](https://www.expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) Mission Valley 8.8/10 Excellent (3,628 reviews) "Love the Kings Inn, always on our travel list!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linzee CA $112 CA $129 total includes taxes & fees Jan 28 - Jan 29 [](https://www.expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ![Children's play area - outdoor](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/aa370e3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c649726f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; Regional cuisine](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/a77f85c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/7f3bc7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) Downtown San Diego 8.4/10 Very good (6,029 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $209 CA $290 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking, Microwave](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/08f46b14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/6a4d216d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/c7295677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/3a81799d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Yacht Harbor Hotel [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) Point Loma 8.6/10 Excellent (1,697 reviews) "Great rate for a great stay!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) James CA $136 CA $156 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-10&endDate=2026-02-11®ionId=6263723&adults=2&travelerType=family_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Otay Mesa Hotel Reviews ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Clean room, comfortable bed and pillow. Spacious and updated." [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Courtyard by Marriott San Diego Downtown Little Italy](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Great hotel!! In the middle of Little Italy. Very walkable. The bar staff were fantastic!" [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg) ### Paradise Point Resort & Spa 10/10 Excellent "Clean. Great location. Hidden treasure. Heated pools. " [](https://expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Nice" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Great stay! " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Everything went good " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Everything looks great " [](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Room was clean and restocked daily. Staff was very courteous." [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![The Sofia Hotel](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Clean, nice friendly staff" [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ## Frequently asked questions ### What's Otay Mesa like for family-friendly vacations? ### What's there to see and do with your family in Otay Mesa? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotel-With-Early-Check-In.0-0-d6068523-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotels-With-Indoor-Pool.0-0-d6068523-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - 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