Title: Book the Best Otay Mesa CASINO Hotels & Resorts in 2026 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Casino Hotels in Otay Mesa, CA from CA $95 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa Casino Hotels Tonight [Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-15&endDate=2025-12-16&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-16&endDate=2025-12-17&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-19&endDate=2025-12-21&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-12-26&endDate=2025-12-28&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa hotels with a casino ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/22ecf276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/250333ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/700997bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/3bb415c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) El Cajon 9.2/10 Wonderful (1633) "Nice rooms. Great food at all restaurants " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steve CA $112 CA $140 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3836h2556x3y3-467b2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/e9cd53ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/e4156a66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3839h2555x0y3-5f9fe6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Imperial Beach San Diego [](https://www.expedia.ca/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) Imperial Beach 9.4/10 Exceptional (950) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Crystal CA $148 CA $168 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/86ae0a3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/a5cb77af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/8bb8fc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/ade03197.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Marina Gateway Hotel [](https://www.expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) National City 9.2/10 Wonderful (3531) "Great friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mohammed CA $143 CA $157 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/f71452c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/5bf5b920.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/a653b43a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996144/4e3a5f44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 El Cajon, CA - San Diego [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) El Cajon 7.4/10 Good (1459) "My stay here was pretty cool" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rana CA $96 CA $105 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/El-Cajon-Hotels-Motel-6-El-Cajon.h996144.Hotel-Information) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/43ae1d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/486f9d1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/6248eb98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/05adb83a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Mission Valley/Hotel Circle [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Mission-ValleyHotel-Circle.h1987617.Hotel-Information) Mission Valley 8.4/10 Very good (1442) "Good place to stay, and clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yuke CA $142 CA $163 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Mission-ValleyHotel-Circle.h1987617.Hotel-Information) ![Arcade](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/ec5cea9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Memory foam beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/df9e8ced.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool, open 9:00 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/8921b04c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/4ef92902.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Rambler [](https://www.expedia.ca/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information) Chula Vista 9.2/10 Wonderful (2000) "The front desk is very kind and the coffee is the best!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alma CA $126 CA $146 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/433d1302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/2b448002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, ocean views ](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/889d28b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/112000000/111960000/111958400/111958344/178c1eb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bower Coronado [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) Historic Downtown Coronado 9.2/10 Wonderful (150) "Great place. Great rooftop bar. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $284 CA $381 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Coronado-Hotels-The-Bower.h111958344.Hotel-Information) ![Coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/18bcfb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/14f93e35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/43f82912.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/58b6effd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 Suites San Ysidro, CA -San Diego South Bay [](https://www.expedia.ca/San-Ysidro-Hotels-Studio-6-Suites-San-Ysidro.h1798071.Hotel-Information) San Ysidro 7.8/10 Good (1407) "Excelente hotel " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Adrian AndrĂ©s CA $96 CA $110 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/San-Ysidro-Hotels-Studio-6-Suites-San-Ysidro.h1798071.Hotel-Information) ![Outdoor wedding area](https://images.trvl-media.com/lodging/7000000/6730000/6728200/6728130/9ab08509.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cooked-to-order breakfast for a fee on weekends](https://images.trvl-media.com/lodging/7000000/6730000/6728200/6728130/7a9d01e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf view](https://images.trvl-media.com/lodging/7000000/6730000/6728200/6728130/1169bbeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6730000/6728200/6728130/f89c33f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carlton Oaks Lodge, an Ascend Collection Hotel [](https://www.expedia.ca/Santee-Hotels-Carlton-Oaks-Lodge.h6728130.Hotel-Information) Santee 8.2/10 Very good (1002) "It was a great place to stay for a quick trip to the town." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcia CA $135 CA $179 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Santee-Hotels-Carlton-Oaks-Lodge.h6728130.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/102000000/101320000/101313900/101313887/b886e58f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101320000/101313900/101313887/c25ab923.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/102000000/101320000/101313900/101313887/5202e595.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually furnished, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/102000000/101320000/101313900/101313887/8db7deb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rodeway Inn El Cajon - San Diego East [](https://www.expedia.ca/El-Cajon-Hotels-EL-CAJON-INN-SUITES.h101313887.Hotel-Information) El Cajon 6.6/10 (96) "Lovely place! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) L and M CA $87 CA $95 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/El-Cajon-Hotels-EL-CAJON-INN-SUITES.h101313887.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-29&endDate=2025-12-30®ionId=6263723&adults=2&amenities=CASINO&sort=RECOMMENDED&openPlayBack=true) ## Top Otay Mesa Hotel Reviews ## Frequently asked questions ### Searching for casino hotels in Otay Mesa? ### What is there to do in Otay Mesa? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotel-With-Early-Check-In.0-0-d6068523-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotels-With-Indoor-Pool.0-0-d6068523-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - 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