Title: Book the Best BUSINESS Hotels in Otay Mesa in 2025 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/business.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Otay Mesa, CA from CA $116 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa Business Hotels Tonight [Oct 22 - Oct 23](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-22&endDate=2025-10-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Otay Mesa Business Hotels ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/eda7e8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/c607b0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Non Smoking (Mobility, Transfer Shower)](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1d234b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG Otay Mesa 8.0/10 Very good (1480) "Very good to stayed " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ramiro CA $167 CA $190 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/673df2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/d3d09d7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa Otay Mesa 7.2/10 Good (1007) "Clean, friendly staff and yummy breakfast :)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Iliana CA $139 CA $158 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/f294be65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/48aa6044.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/d3b44b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/16da1e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza San Diego - Mission Valley by IHG Mission Valley 7.8/10 Good (1052) "Good value Nice place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $143 CA $165 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/76b78879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/c3607c60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/143ad063.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/41000/40962/87da6900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden San Diego Near SeaWorld Point Loma 7.4/10 Good (4092) "Really good place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $119 CA $136 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-Garden-San-Diego-Near-SeaWorld.h40962.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse](https://images.trvl-media.com/lodging/1000000/10000/900/858/36c2b78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/900/858/93b051f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina Mission Bay 8.4/10 Very good (1554) "Clean rooms great view amazing pool and we loved the breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ad CA $237 CA $347 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/1f4c359a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/250333ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/8995625e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/91cdc1c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort El Cajon 9.2/10 Wonderful (1582) "Great resort!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicky CA $126 CA $156 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Outdoor pool, open 7:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/91a184a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/abbee14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/633cc48d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/56fafd1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club University Heights 9.4/10 Exceptional (1229) "10/10 looooove loooove this place will be coming back " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Moises CA $317 CA $364 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/7cb5b7d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/52554aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/cc6aac5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/98dcc319.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Humphreys Half Moon Inn Point Loma 9.2/10 Wonderful (2591) "Great hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adil CA $223 CA $284 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Humphreys-Half-Moon-Inn.h36183.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/w3837h2560x3y0-07d390b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/w3837h2557x3y3-122e500e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/36f8ccfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection Downtown San Diego 8.8/10 Excellent (565) "Great place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $167 CA $194 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/d29cf820.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/234557f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking, Corner (with Single Sofabed;Larger Room)](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3837h2877x3y3-6cbb3bd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-498f6208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western San Diego Pacific Beach/Mission Bay Bay Park 7.2/10 Good (1303) "Excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Alerson CA $101 CA $116 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-Diego-Pacific-BeachMission-Bay.h18147.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-05&endDate=2025-11-06®ionId=6263723&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Otay Mesa Hotel Reviews ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Great View, close to the concert!" [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Older property but great location. Friendly staff and lots nearby. " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Courtyard by Marriott San Diego Downtown Little Italy](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Amazing staff! From front desk to dinning and bar area! Safe area, walking distance to restaurants " [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "The only negative is you have to pay for parking daily $35 and a fee " [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Manchester Grand Hyatt San Diego](//images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4_y.jpg) ### Manchester Grand Hyatt San Diego 10/10 Excellent "The hotel is beautiful and conveniently located near Seaport Village, offering everything you need within walking distance. You and your family can fully enjoy your stay without having to venture far—Seaport Village and the hotel itself provide plenty to experience. The dining options are both affordable and excellent. There is truly no better hotel to choose from." [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Super easy check in process, staff was extremely hospitable. My room was comfortable as well. Great job Hilton" [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](//images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great for the price" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Wyndham Garden San Diego Near SeaWorld](//images.trvl-media.com/lodging/1000000/50000/41000/40962/76b78879_y.jpg) ### Wyndham Garden San Diego Near SeaWorld 10/10 Excellent "Great location. Very central. Did not love how you can hear everything outside your room " [](https://expedia.ca/San-Diego-Hotels-Wyndham-Garden-San-Diego-Near-SeaWorld.h40962.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](//images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "It was a quick over night stay. Did not use any additional amenities. Always enjoy the warm cookies!" [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in Otay Mesa with Expedia? > Here at Expedia, our business is to help you land an excellent stay at the right price. From upmarket, corporate-friendly retreats to affordable hotels loaded with amenities, you'll have your next work trip organized in a few quick clicks. ### How can I find cheap business-friendly hotels in Otay Mesa? > Select the "business friendly" filter, listed under the "traveller experience" heading, to find cheap business-friendly hotels in Otay Mesa. Then refine your search by your nightly budget. 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