Title: Hotels by Best Western in Otay Mesa from CA $123 | Expedia.ca [Otay Mesa Travel Guide](https://expedia.ca/San-Diego-Otay-Mesa.dx6263723)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 25 - Jan 26](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-25&endDate=2026-01-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 26 - Jan 27](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-26&endDate=2026-01-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa Best Western ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/297b9804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/e17b5b7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/0303dbfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/50e4f8af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Inn & Suites San Diego – Zoo/SeaWorld Area [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) Mission Valley 8.0/10 Very good (2,402 reviews) "Nice hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lamberto Jr CA $150 CA $173 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3840h2556x0y3-1156c5d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-2f0f89f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-6971afdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Seven Seas [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) Mission Valley 8.0/10 Very good (3,169 reviews) "The place and room was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Trinidad CA $107 CA $123 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/bc7617fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/5a519562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/ddddbc6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ad23cf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Chula Vista/Otay Valley Hotel [](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) Otay 7.8/10 Good (1,585 reviews) "Clean rooms and the breakfast was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vanessa CA $139 CA $152 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/025fd645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/e40d2481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/2ba90811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/44f8822a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Americana Inn [](https://www.expedia.ca/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) San Ysidro 8.8/10 Excellent (1,214 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elisa CA $150 CA $171 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking, Microwave](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/08f46b14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/02dbf386.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/c7295677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21600/21527/6a4d216d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Yacht Harbor Hotel [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) Point Loma 8.6/10 Excellent (1,695 reviews) "Great rate for a great stay!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) James CA $136 CA $156 total includes taxes & fees Jan 27 - Jan 28 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Yacht-Harbor-Hotel.h21527.Hotel-Information) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-498f6208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/a137d768.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/1a78c634.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/18200/18147/w3840h2877x0y3-a0181fa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western San Diego Pacific Beach/Mission Bay [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-Diego-Pacific-BeachMission-Bay.h18147.Hotel-Information) Bay Park 8.4/10 Very good (250 reviews) "Clean hotel & great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) yardley CA $127 CA $146 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-San-Diego-Pacific-BeachMission-Bay.h18147.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/1954ac96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/bb0bbb71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/3bd865c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Kitchenette (with Sofabed)](https://images.trvl-media.com/lodging/1000000/30000/27100/27004/e868665c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Santee Lodge [](https://www.expedia.ca/Santee-Hotels-Best-Western-Santee-Lodge.h27004.Hotel-Information) Santee 7.8/10 Good (603 reviews) " Room was clean and the staff was friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $154 CA $169 total includes taxes & fees Jan 28 - Jan 29 [](https://www.expedia.ca/Santee-Hotels-Best-Western-Santee-Lodge.h27004.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/8edd50b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/c3b7953f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking, Refrigerator](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/6b4abe60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/973700/973615/3ce0d724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Downtown San Diego [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Cabrillo-Garden-Inn.h973615.Hotel-Information) Downtown San Diego 8.4/10 Very good (930 reviews) "Room was ckean and the staff was courteous." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Juan CA $186 CA $212 total includes taxes & fees Jan 28 - Jan 29 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Cabrillo-Garden-Inn.h973615.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-08&endDate=2026-02-09®ionId=6263723&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Best-Western.0-n6263723-0--bBestWestern.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels-Best-Western.0-n6263723-0--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Otay Mesa Hotel Reviews ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Nice" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Great stay! " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Everything went good " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Everything looks great " [](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Room was clean and restocked daily. Staff was very courteous." [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![The Sofia Hotel](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Clean, nice friendly staff" [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Pendry San Diego](https://images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Good hotel " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![Sentral Gaslamp Quarter](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/b82a5191_y.jpg) ### Sentral Gaslamp Quarter 10/10 Excellent "Staff is very nice " [](https://expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Outstanding service we loved it and will go back again. " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ## Find out more about Otay Mesa ## Otay Mesa Hotels Guide Expedia.ca offers a selection of 4898 hotels in Otay Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Otay Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Otay Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Otay Mesa, San Diego now! ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [Hilton Hotels in Altadena ](https://www.expedia.ca/Altadena-San-Diego-Hotels-Hilton-Hotels.0-n553248635976472078-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Bartell Hotels in Barrio Logan ](https://www.expedia.ca/Barrio-Logan-San-Diego-Hotels-Bartell-Hotels.0-n553248635976388733-0--bBartellHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Bonita ](https://www.expedia.ca/Bonita-Hotels-La-Quinta-Inn-Suites.0-0-d177687--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Hotels near Brown Field Municipal ](https://www.expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Casa de Oro-Mount Helix ](https://www.expedia.ca/Casa-De-Oro-Mount-Helix-Hotels-Wyndham-Extra-Holidays.0-0-d553248635975875970--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - 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