Title: Book the Best Orangeburg LUXURY Hotels - Upscale Hotels in Orangeburg, SC | Expedia.ca [Orangeburg Travel Guide](https://expedia.ca/Orangeburg.dx6058108)[Hotels in Orangeburg](https://expedia.ca/Orangeburg-Hotels.d6058108.Travel-Guide-Hotels)[Vacation Rentals in Orangeburg](https://expedia.ca/Orangeburg-Vacation-Rentals.d6058108.Travel-Guide-VacationRentals)[Flights to Orangeburg](https://expedia.ca/Cheap-Flights-To-Orangeburg.d6058108.Travel-Guide-Flights)[Orangeburg Car Rentals](https://expedia.ca/Car-Rentals-In-Orangeburg.d6058108.Car-Rental-Guide)[Orangeburg Vacation Packages](https://expedia.ca/Orangeburg.d6058108.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/d91715fa11e9d5570856838fd5bd4287.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Corey Dargan # Find luxury hotels in Orangeburg, SC - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Orangeburg Luxury Hotels Tonight [Oct 31 - Nov 1](https://www.expedia.ca/Hotel-Search?regionId=6058108&startDate=2025-10-31&endDate=2025-11-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6058108&startDate=2025-11-01&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6058108&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6058108&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Orangeburg Luxury Hotels ![Breakfast area](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/5f1ffd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking | Bathroom sink](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/13cfcb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Smoking](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/77c6db86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Orangeburg Orangeburg 8.2/10 Very good (1004) "Clean room, comfortable bed, staff was welcoming " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary Diane CA $99 CA $110 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/b105c391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/e9087580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee Santee 6.6/10 (631) "It's a quiet tuck back hotel. Although the front desk lady was extremely rude and tried to over charge me several times. The property manager was very professional." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Monica CA $88 CA $98 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/91286f8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/2824d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/6e319d52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee Santee 8.0/10 Very good (1003) "Good place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) omar CA $147 CA $163 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/3438166f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/581bc335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/b15e751d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/1000000/30000/20500/20500/3e8501ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Orangeburg North Orangeburg 6.0/10 (1003) "Clean room. Great AC……..runs quietly and strong." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fred CA $71 CA $79 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c7187353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee Santee 8.0/10 Very good (1382) "A nice location, plenty of parking, nice that breakfast was included. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alyssa CA $105 CA $116 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/61b41f5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/23463ec8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Santee I-95 Santee 6.2/10 (537) "The grounds and property were clean and you could tell they take pride in what they're offering." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric CA $100 CA $111 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/1f93ecf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/60673add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/3b5b7fa1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/6c8567ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Santee 6.4/10 (309) "It was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $88 CA $98 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-14&endDate=2025-11-15®ionId=6058108&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Orangeburg Hotel Reviews ![Travelodge by Wyndham Orangeburg](//images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f_y.jpg) ### Travelodge by Wyndham Orangeburg 10/10 Excellent "This older motel is always clean, always " [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![Baymont by Wyndham Orangeburg North](//images.trvl-media.com/lodging/1000000/30000/20500/20500/3438166f_y.jpg) ### Baymont by Wyndham Orangeburg North 10/10 Excellent "The room did what it needed to do." [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Orangeburg-North.h20500.Hotel-Information) ## Frequently asked questions ### Are you searching for the perfect hotel for your luxury holiday in Orangeburg? > Use Expedia and let us help you arrange a flight to Columbia Metropolitan Airport (CAE) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Orangeburg offers. During your visit, you might want to enjoy the sporting events and university which Orangeburg is known for. ### When can I expect good weather in Orangeburg? > Planning for the weather is a good way to make your trip to Orangeburg relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 51°F. Average annual precipitation for Orangeburg is 52 inches. ### What's there to see and do in Orangeburg? > Experience Orangeburg with a stop at Edisto Memorial Gardens, South Carolina State College Historic District, and Smith-Hammond-Middleton Memorial Center. 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