Title: Browse the Best Orangeburg County Resorts | Expedia.ca [Orangeburg County Hotels](https://expedia.ca/Destinations-In-Orangeburg-County.d553248635996998003.Hotel-Destinations)[Vacation Rentals in Orangeburg County](https://expedia.ca/Destinations-In-Orangeburg-County.d553248635996998003.Vacation-Rental-Destinations)[Orangeburg County Car Rentals](https://expedia.ca/Destinations-In-Orangeburg-County.d553248635996998003.Car-Rental-Destinations)[Orangeburg County Vacations](https://expedia.ca/Orangeburg-County.d553248635996998003.Destination-Travel-Guides) ![The Branchville Railroad Depot is listed on the National Register of Historic Places. The front of the structure now houses a museum/shrine of railroad memorabilia, including a caboose. It is open by appointment and children are welcome. Informal tours are led by John Norris, a retired railroad company executive. Admission is free but donations toward the upkeep of the museum are appreciated. Call (803) 707-1788 for information. The rear of the structure houses the Eatery at the Depot, which serves dinners on Thursday, Friday and Saturday evenings. Reservations are recommended but not required. Call (803) 274-8001 or (803) 515-](https://images.trvl-media.com/place/3000455875/43d228a3-3ea8-4c0d-b974-e33e83be19a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Sara Dean / Race2Beach ![](https://images.trvl-media.com/place/3000455875/43d228a3-3ea8-4c0d-b974-e33e83be19a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635996998003&startDate=2026-01-30&endDate=2026-02-01&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635996998003&startDate=2026-02-06&endDate=2026-02-08&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248635996998003&startDate=2026-02-20&endDate=2026-02-22&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=553248635996998003&startDate=2026-03-20&endDate=2026-03-22&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cities in Orangeburg County ![](https://mediaim.expedia.com/destination/2/d91715fa11e9d5570856838fd5bd4287.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Orangeburg [](https://expedia.ca/Orangeburg-Resort-Hotels.d6058108-aaResortHotels.Travel-Guide-Accommodation) ## Our top choices for Orangeburg County resorts ![Interior](https://images.trvl-media.com/lodging/103000000/102020000/102018300/102018216/67115d00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/103000000/102020000/102018300/102018216/fd2945fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102020000/102018300/102018216/8544d4ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/103000000/102020000/102018300/102018216/fb378afa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Waterfront Condo on Lake Marion [](https://www.expedia.ca/Santee-Hotels-Spacious-Condo-On-Beautiful-Lake-Marion.h102018216.Hotel-Information) Santee 10/10 Exceptional (6 reviews) "This place was outstanding, clean and beautifully decorated. I will rent this property again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tuwanna G. [](https://www.expedia.ca/Santee-Hotels-Spacious-Condo-On-Beautiful-Lake-Marion.h102018216.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/109000000/108970000/108963600/108963596/b1937017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, soap, shampoo](https://images.trvl-media.com/lodging/109000000/108970000/108963600/108963596/62c27d79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Marion 2Bed/2Bath Deluxe! [](https://www.expedia.ca/Santee-Hotels-Lake-Marion-2Bed2Bath-Deluxe.h108963596.Hotel-Information) Santee [](https://www.expedia.ca/Santee-Hotels-Lake-Marion-2Bed2Bath-Deluxe.h108963596.Hotel-Information) ![Hair dryer, towels, soap, shampoo](https://images.trvl-media.com/lodging/109000000/108970000/108964200/108964119/bcd8bf6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Marion 3Bed/3Bath Deluxe! [](https://www.expedia.ca/Santee-Hotels-Lake-Marion-3Bed3Bath-Deluxe.h108964119.Hotel-Information) Santee [](https://www.expedia.ca/Santee-Hotels-Lake-Marion-3Bed3Bath-Deluxe.h108964119.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/109000000/108970000/108962500/108962490/5692bed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, soap, shampoo](https://images.trvl-media.com/lodging/109000000/108970000/108962500/108962490/bca2cf62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 2Bed/2Bath Deluxe at Lake Marion! [](https://www.expedia.ca/Santee-Hotels-2Bed2Bath-Deluxe-At-Lake-Marion.h108962490.Hotel-Information) Santee [](https://www.expedia.ca/Santee-Hotels-2Bed2Bath-Deluxe-At-Lake-Marion.h108962490.Hotel-Information) ![Hair dryer, towels, soap, shampoo](https://images.trvl-media.com/lodging/109000000/108970000/108963200/108963171/6008f4d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3Bed/3Bath Deluxe at Lake Marion! [](https://www.expedia.ca/Santee-Hotels-3Bed3Bath-Deluxe-At-Lake-Marion.h108963171.Hotel-Information) Santee [](https://www.expedia.ca/Santee-Hotels-3Bed3Bath-Deluxe-At-Lake-Marion.h108963171.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-03&endDate=2026-02-04®ionId=553248635996998003&adults=2&lodging=HOTEL_RESORT&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOrangeburg-County-Resort-Hotels.d553248635996998003-aaResortHotels.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOrangeburg-County-Resort-Hotels.d553248635996998003-aaResortHotels.Travel-Guide-Accommodation) ## Top Orangeburg County Hotel Reviews ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg) ### Tru By Hilton Santee 10/10 Excellent "Very nice! Very friendly check in, great beds & shower, very clean. Easy to reach from I 95." [](https://expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Staff was very friendly and the room was large and very clean. " [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Travelodge by Wyndham Orangeburg](https://images.trvl-media.com/lodging/18000000/17390000/17380300/17380261/bfdc100f_y.jpg) ### Travelodge by Wyndham Orangeburg 10/10 Excellent "Property and rooms, super clean, staff is always up to top level, helpful and efficient. An older property but splendidly maintained. The best value for money in the whole cluster of hotels and exit 145 of 26.. " [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Orangeburg.h17380261.Hotel-Information) ![Hampton Inn & Suites Orangeburg](https://images.trvl-media.com/lodging/10000000/9860000/9854700/9854604/637dd914_y.jpg) ### Hampton Inn & Suites Orangeburg 10/10 Excellent "Clean room, helpful and friendly front desk staff. Tasty breakfast." [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Suites-Orangeburg.h9854604.Hotel-Information) ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "The room is elegant" [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "The outside of the building is nothing to look at, but the room was modern, clean, had good bathrooms, was spacious. Had a larger refrigerator and a microwave. Very comfortable for an overnight stay. The price was great too" [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "Some recent updates are much appreciated. Staff is always very nice. The grounds and the room are very clean." [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Fairfield Inn by Marriott Orangeburg](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/aa173c27_y.jpg) ### Fairfield Inn by Marriott Orangeburg 10/10 Excellent "The room was nice " [](https://expedia.ca/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) ![Tru by Hilton Orangeburg](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/1bbd70f5_y.jpg) ### Tru by Hilton Orangeburg 10/10 Excellent "Staff was 100/10!! They are the ones who made my stay unforgettable. I also received a daily text to make sure everything was good okay. So many quick food places within the vicinity. The lounge area was pretty nice/cool. I did not get a chance to eat breakfast. Highly recommend Tru! " [](https://expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ## Find out more about Orangeburg County ## Orangeburg County Resorts information | Number of reviews | 6 | | ----------------- | --------- | | Accommodation | 5 Resorts | | Lowest Price | | | Highest Price | | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Norway ](https://www.expedia.ca/5Star-Norway-Hotels.s50-0-d553248634998816179.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Bamberg ](https://www.expedia.ca/Bamberg-Hotels-Cheap-Hotels.0-0-d55570-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Bamberg ](https://www.expedia.ca/Bamberg-Hotels-Family-Hotel.0-0-d55570-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Bamberg ](https://www.expedia.ca/Bamberg-Hotels-Luxury-Hotel.0-0-d55570-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Bamberg Hotels ](https://www.expedia.ca/Bamberg-Hotels.d55570.Travel-Guide-Hotels) - 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