Title: Book the Best North Central San Diego LUXURY Hotels - Upscale Hotels in North Central San Diego, CA | Expedia.ca

[North Central San Diego Travel Guide](https://expedia.ca/North-Central-San-Diego.dx553248633938928037)[Hotels in North Central San Diego](https://expedia.ca/North-Central-San-Diego-Hotels.d553248633938928037.Travel-Guide-Hotels)[Vacation Rentals in North Central San Diego](https://expedia.ca/North-Central-San-Diego-Vacation-Rentals.d553248633938928037.Travel-Guide-VacationRentals)[Flights to North Central San Diego](https://expedia.ca/Cheap-Flights-To-North-Central-San-Diego.d553248633938928037.Travel-Guide-Flights)[North Central San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-North-Central-San-Diego.d553248633938928037.Car-Rental-Guide)[North Central San Diego Vacation Packages](https://expedia.ca/North-Central-San-Diego.d553248633938928037.Destination-Travel-Guides)

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## Check availability on North Central San Diego Luxury Hotels

Tonight

[Jan 28 - Jan 29](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2026-01-28&endDate=2026-01-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Tomorrow

[Jan 29 - Jan 30](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2026-01-29&endDate=2026-01-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

This weekend

[Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Next weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

## Top North Central San Diego Hotel Reviews

![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg)

### The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent

"Great little spot, also very. close to Little Italy farmers market. The staff was very friendly and accommodating. if need a place for a quick get a way this is it. "

[](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information)

![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg)

### Hilton San Diego Mission Valley

10/10 Excellent

"staff were friendly and accommodating."

[](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information)

![Courtyard by Marriott San Diego Downtown Little Italy](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff_y.jpg)

### Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent

"Great hotel!! In the middle of Little Italy. Very walkable. The bar staff were fantastic!"

[](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information)

![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/bc1e5add_y.jpg)

### Paradise Point Resort & Spa

10/10 Excellent

"Clean. Great location. Hidden treasure. Heated pools. "

[](https://expedia.ca/San-Diego-Hotels-Paradise-Point-Resort-Spa.h3731.Hotel-Information)

![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg)

### Days Inn by Wyndham San Diego Hotel Circle

10/10 Excellent

"Nice"

[](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information)

![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg)

### Wyndham San Diego Bayside

10/10 Excellent

"Great stay! "

[](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information)

![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg)

### The Dana on Mission Bay

10/10 Excellent

"Everything went good "

[](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information)

![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg)

### Bay Club Hotel & Marina

10/10 Excellent

"Everything looks great "

[](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information)

![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg)

### Hard Rock Hotel San Diego

10/10 Excellent

"Room was clean and restocked daily. Staff was very courteous."

[](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information)

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