Title: Book the Best BUSINESS Hotels in North Central San Diego in 2026 | Expedia.ca [North Central San Diego Travel Guide](https://expedia.ca/North-Central-San-Diego.dx553248633938928037)[Hotels in North Central San Diego](https://expedia.ca/North-Central-San-Diego-Hotels.d553248633938928037.Travel-Guide-Hotels)[Vacation Rentals in North Central San Diego](https://expedia.ca/North-Central-San-Diego-Vacation-Rentals.d553248633938928037.Travel-Guide-VacationRentals)[Flights to North Central San Diego](https://expedia.ca/Cheap-Flights-To-North-Central-San-Diego.d553248633938928037.Travel-Guide-Flights)[North Central San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-North-Central-San-Diego.d553248633938928037.Car-Rental-Guide)[North Central San Diego Vacation Packages](https://expedia.ca/North-Central-San-Diego.d553248633938928037.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/3073/1edd2210-6df3-4887-ad63-87169c60539a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in North Central San Diego, CA from CA $127 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on North Central San Diego Business Hotels Tonight [Dec 19 - Dec 20](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2025-12-19&endDate=2025-12-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 20 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2025-12-20&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248633938928037&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for North Central San Diego business-friendly hotels ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/900/858/c6795882.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/10000/900/858/c095adf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Corner](https://images.trvl-media.com/lodging/1000000/10000/900/858/721ac3a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) Mission Bay 8.4/10 Very good (1573) "Loved our stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeremy CA $171 CA $270 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![Room, 1 King Bed with Sofa bed, Marina View | View from room](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/1f402c59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/14f99248.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; Mexican cuisine](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/252aa24a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton San Diego Resort [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) Harbor Island 8.4/10 Very good (3162) "Great stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $146 CA $218 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/483e1c41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/8fd57751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/089f0b78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/60000/50100/50032/8aabd9fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ayres Lodge Alpine [](https://www.expedia.ca/Alpine-Hotels-Ayres-Lodge-Alpine.h50032.Hotel-Information) Alpine 9.2/10 Wonderful (1008) "Large rooms,very clean, wonderful breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Becky [](https://www.expedia.ca/Alpine-Hotels-Ayres-Lodge-Alpine.h50032.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/aa48478b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/ad83f8b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/9862c417.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/b3ef3ceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton San Diego - Del Mar [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) Carmel Valley 8.4/10 Very good (1891) "Excellent location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paolo CA $135 CA $154 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778037/c6aee7bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778037/f5673282.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778037/4c1ca929.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778037/6999adfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn San Diego Del Mar [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-DiegoDel-Mar.h1778037.Hotel-Information) Carmel Valley 8.6/10 Excellent (1000) "Everything was excellent. Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $137 CA $157 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-DiegoDel-Mar.h1778037.Hotel-Information) ![Outdoor pool, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/1000000/810000/807600/807521/bd6ac666.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/807600/807521/041f688c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/810000/807600/807521/8d1301b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/810000/807600/807521/6556ef22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott Del Mar [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Del-Mar.h807521.Hotel-Information) Carmel Valley 8.6/10 Excellent (1003) "Nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacqueline CA $221 CA $252 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Del-Mar.h807521.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/49f2cd82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/bc2ee3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/8ae9b43e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/5700/5684/0d512cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego - Miramar [](https://www.expedia.ca/San-Diego-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Miramar.h5684.Hotel-Information) Rancho Peñasquitos 7.8/10 Good (1101) "It was a great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cherie CA $110 CA $127 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Miramar.h5684.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1152200/1152196/67b2bb02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1152200/1152196/e290b33c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1160000/1152200/1152196/66925a4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1152200/1152196/caf40983.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn San Diego - Rancho Bernardo [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-Rancho-Bernardo.h1152196.Hotel-Information) Rancho Bernardo 8.6/10 Excellent (1000) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandra CA $168 CA $192 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-Rancho-Bernardo.h1152196.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/911600/911534/8793d34a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/920000/911600/911534/a4220190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/920000/911600/911534/19e7828e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/920000/911600/911534/b03e8933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott San Diego-Scripps Poway [](https://www.expedia.ca/San-Diego-Hotels-SpringHill-Suites-By-Marriott-San-Diego-Scripps-Poway.h911534.Hotel-Information) Miramar Ranch North 8.8/10 Excellent (1129) "Great place to stay! Will definitely stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory CA $169 CA $194 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Diego-Hotels-SpringHill-Suites-By-Marriott-San-Diego-Scripps-Poway.h911534.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/15800/15731/6dbceb69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/15800/15731/09b93864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/15800/15731/b6c96fd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/15800/15731/fb3415c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego - Rancho Bernardo [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Rancho-Bernardo.h15731.Hotel-Information) Rancho Bernardo 8.4/10 Very good (1002) "Enjoyed our stop here on our way to San Diego " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eddie CA $186 CA $212 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Rancho-Bernardo.h15731.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-02&endDate=2026-01-03®ionId=553248633938928037&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top North Central San Diego Hotel Reviews ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "really big rooms and delicious breakfast! would come back again" [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![San Diego Marriott La Jolla](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg) ### San Diego Marriott La Jolla 10/10 Excellent "Easy access to where I needed to be & lots of food options nearby at the mall. Clean & comfortable!" [](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Fantastic location for catching a cruise. Right across the street!!! Great views as well! " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Nice room and beds" [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean. Great room " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "The hotel was clean, festive and helpful. Very accommodating. I will definitely come back. " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "It was great " [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Staff was friendly room was very clean " [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "We love staying here. The pool is great for us all. We love the rooms that have patios and our boys can play on the grass right in front of room. " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in North Central San Diego cost? ### How many business-friendly hotels are there in North Central San Diego? ### Why book your business-friendly hotel in North Central San Diego with Expedia? ### How can I find cheap business-friendly hotels in North Central San Diego? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Adults Only Resorts & in Black Mountain Ranch ](https://www.expedia.ca/Black-Mountain-Ranch-San-Diego-Hotels-Adults-Only-Resorts.0-n797416278820573184-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Black Mountain Ranch ](https://www.expedia.ca/Black-Mountain-Ranch-San-Diego-Hotels-All-Inclusive-Hotel.0-n797416278820573184-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Black Mountain Ranch ](https://www.expedia.ca/Black-Mountain-Ranch-San-Diego-Hotels-Boutique-Hotel.0-n797416278820573184-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - 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