Title: Book the Best BUSINESS Hotels in North Central Florida in 2026 | Expedia.ca [North Central Florida Travel Guide](https://expedia.ca/North-Central-Florida.dx6233773)[Hotels in North Central Florida](https://expedia.ca/North-Central-Florida-Hotels.d6233773.Travel-Guide-Hotels)[Vacation Rentals in North Central Florida](https://expedia.ca/North-Central-Florida-Vacation-Rentals.d6233773.Travel-Guide-VacationRentals)[Flights to North Central Florida](https://expedia.ca/Cheap-Flights-To-North-Central-Florida.d6233773.Travel-Guide-Flights)[Things to do in North Central Florida](https://expedia.ca/Things-To-Do-In-North-Central-Florida.d6233773.Travel-Guide-Activities)[North Central Florida Car Rentals](https://expedia.ca/Car-Rentals-In-North-Central-Florida.d6233773.Car-Rental-Guide)[North Central Florida Vacation Packages](https://expedia.ca/North-Central-Florida.d6233773.Destination-Travel-Guides) ![One of the famous glass bottom boats in Silver Springs State Park (Ocala, FL) floats by on the crystal clear water of the Silver River. If you visit Silver Springs, you must take one of these boat rides. In addition to seeing the underwater springs, we also saw manatees, alligators, turtles, monkeys, and birds on our 90 minute tour. #silversprings #florida](https://images.trvl-media.com/place/10102/70ef890d-5a7e-4d7c-ac71-04c7a28a93cd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jen - Nealys On Wheels # Find Business Hotels in North Central Florida, FL from CA $102 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on North Central Florida Business Hotels Tonight [Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2025-12-26&endDate=2025-12-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2025-12-27&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for North Central Florida business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/9ec8c850.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/9f59799c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/87e50709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/902a0c63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Dunnellon near Rainbow Springs [](https://www.expedia.ca/Crystal-River-Hotels-Comfort-Suites-Near-Rainbow-Springs.h12704476.Hotel-Information) Dunnellon 9.0/10 Wonderful (1002) "The breakfast was fresh and facilities were clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janett CA $134 CA $150 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Crystal-River-Hotels-Comfort-Suites-Near-Rainbow-Springs.h12704476.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/82e386c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/cb41e4e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/89f48c41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Live Oak by IHG [](https://www.expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) Live Oak 8.4/10 Very good (775) "Have stayed here whenever we are in town. Always god stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregg CA $165 CA $181 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/9a0ddc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/8207aeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/w4000h2664x0y0-4664f427.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/00752d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Lake City [](https://www.expedia.ca/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information) Lake City 9.0/10 Wonderful (169) "Very clean, friendly staff, safe and quiet " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy CA $122 CA $137 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/47bbd7f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/0ead3b62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/e1dc2812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/fd7eab0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn White Springs Suwanee [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) Live Oak 7.2/10 Good (618) "Clean rooms, very friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristin L CA $93 CA $102 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/d39ee4a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/0124d3bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/45cc4db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lake City [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) Lake City 9.4/10 Exceptional (1003) "Clean room, staff, everyone super helpful ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Devang CA $159 CA $178 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/cba0289f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/41454f4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/e8bf5c2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites University/Shands [](https://www.expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) Gainesville 8.8/10 Excellent (1050) "Clean room and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $101 CA $121 total includes taxes & fees Jan 9 - Jan 10, 2026 [](https://www.expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/7f945643.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/c94f1402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/695b0a91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/70b1f0e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Lake City [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) Lake City 9.6/10 Exceptional (1000) "Great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alison CA $146 CA $165 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17300/17274/10297322.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/17300/17274/087f9766.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17300/17274/a6972ed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave (Shower Only)](https://images.trvl-media.com/lodging/1000000/20000/17300/17274/4eafb70d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Starke [](https://www.expedia.ca/Gainesville-Hotels-Best-Western-Starke.h17274.Hotel-Information) Starke 8.6/10 Excellent (665) "staff was great but construction was noisy." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Duane CA $108 CA $120 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Gainesville-Hotels-Best-Western-Starke.h17274.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/dc8aa87c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/f5ec1000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/1240f4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Lake City [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) Lake City 9.2/10 Wonderful (1013) "Fantastic stay 10/10" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $113 CA $127 total includes taxes & fees Dec 31 - Jan 1, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/c38f0eff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast on weekdays](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/81ba003e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/b562f911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suite by Wyndham Lake City [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) Lake City 8.8/10 Excellent (1016) "Very clean property and a full hot breakfast buffet! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie CA $128 CA $144 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-09&endDate=2026-01-10®ionId=6233773&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top North Central Florida Hotel Reviews ![Equus Inn Ocala](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/8ea1560b_y.jpg) ### Equus Inn Ocala 10/10 Excellent "Clean room" [](https://expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) ![DoubleTree by Hilton Gainesville](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/ff7eaa86_y.jpg) ### DoubleTree by Hilton Gainesville 10/10 Excellent "Clean and comfortable room. Convenient location. Safe parking and easy access. The breakfast was great." [](https://expedia.ca/Gainesville-Hotels-DoubleTree-By-Hilton-Gainesville.h49617.Hotel-Information) ![Days Inn by Wyndham Ocala North](https://images.trvl-media.com/lodging/1000000/10000/900/818/ffb5d22e_y.jpg) ### Days Inn by Wyndham Ocala North 10/10 Excellent "Much better than expected " [](https://expedia.ca/Ocala-Hotels-Days-Inn-By-Wyndham-Ocala-North.h818.Hotel-Information) ![Best Western Gateway Grand](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/9a241e09_y.jpg) ### Best Western Gateway Grand 10/10 Excellent "Everything was on point. " [](https://expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) ![Sleep Inn & Suites University/Shands](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9_y.jpg) ### Sleep Inn & Suites University/Shands 10/10 Excellent "The property was right off I-75 and parking was easy. The property was clean and comfortable. The staff was friendly and courteous. " [](https://expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![Hilton University of Florida Conference Center Gainesville](https://images.trvl-media.com/lodging/1000000/480000/475300/475205/7dbdcf15_y.jpg) ### Hilton University of Florida Conference Center Gainesville 10/10 Excellent "Lobby customer service was below par." [](https://expedia.ca/Gainesville-Hotels-Hilton-University-Of-Florida-Conference-Center-Gainesville.h475205.Hotel-Information) ![Howard Johnson by Wyndham Ocala FL I-75](https://images.trvl-media.com/lodging/1000000/50000/41500/41471/40bf238e_y.jpg) ### Howard Johnson by Wyndham Ocala FL I-75 10/10 Excellent "Nice staff and room was clean" [](https://expedia.ca/Ocala-Hotels-Howard-Johnson-By-Wyndham-Ocala-FL.h41471.Hotel-Information) ![Country Inn & Suites by Radisson, Gainesville, FL](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/8584a629_y.jpg) ### Country Inn & Suites by Radisson, Gainesville, FL 10/10 Excellent "Staff was as friendly as anywhere I’ve stayed before…so kind from check-in to check-out. Room was very nice and it was very quiet (read reviews about it being loud but our room was pleasant!). Would definitely stay here again when in the area. " [](https://expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Comfort Inn University](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85_y.jpg) ### Comfort Inn University 10/10 Excellent "Clean room, friendly and attentive staff, very conveniently located." [](https://expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in North Central Florida cost? ### What are the best business-friendly hotels in North Central Florida? ### How many business-friendly hotels are there in North Central Florida? ### What are the best cheap business-friendly hotels in North Central Florida? ### Are there any family-friendly hotels in North Central Florida that are also business friendly? ### Why book your business-friendly hotel in North Central Florida with Expedia? ### How can I find cheap business-friendly hotels in North Central Florida? ### What is there to do in North Central Florida near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Green Hotels in Daytona Beach ](https://www.expedia.ca/Daytona-Beach-Hotels-Green-Sustainable.0-0-d6023995-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in Daytona Beach ](https://www.expedia.ca/Daytona-Beach-Hotels-Honeymoon-Hotels.0-0-d6023995-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - 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