Title: Book the Best BUSINESS Hotels in North Central Florida in 2026 | Expedia.ca [North Central Florida Travel Guide](https://expedia.ca/North-Central-Florida.dx6233773)[Hotels in North Central Florida](https://expedia.ca/North-Central-Florida-Hotels.d6233773.Travel-Guide-Hotels)[Vacation Rentals in North Central Florida](https://expedia.ca/North-Central-Florida-Vacation-Rentals.d6233773.Travel-Guide-VacationRentals)[Flights to North Central Florida](https://expedia.ca/Cheap-Flights-To-North-Central-Florida.d6233773.Travel-Guide-Flights)[Things to do in North Central Florida](https://expedia.ca/Things-To-Do-In-North-Central-Florida.d6233773.Travel-Guide-Activities)[North Central Florida Car Rentals](https://expedia.ca/Car-Rentals-In-North-Central-Florida.d6233773.Car-Rental-Guide)[North Central Florida Vacation Packages](https://expedia.ca/North-Central-Florida.d6233773.Destination-Travel-Guides) ![One of the famous glass bottom boats in Silver Springs State Park (Ocala, FL) floats by on the crystal clear water of the Silver River. If you visit Silver Springs, you must take one of these boat rides. In addition to seeing the underwater springs, we also saw manatees, alligators, turtles, monkeys, and birds on our 90 minute tour. #silversprings #florida](https://images.trvl-media.com/place/10102/70ef890d-5a7e-4d7c-ac71-04c7a28a93cd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jen - Nealys On Wheels # Find Business Hotels in North Central Florida, FL from CA $117 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on North Central Florida Business Hotels Tonight [Dec 31 - Jan 1](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2025-12-31&endDate=2026-01-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 1 - Jan 2](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-01-01&endDate=2026-01-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for North Central Florida business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/9ec8c850.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/dc34db6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/902a0c63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/87e50709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Dunnellon near Rainbow Springs [](https://www.expedia.ca/Crystal-River-Hotels-Comfort-Suites-Near-Rainbow-Springs.h12704476.Hotel-Information) Dunnellon 9.0/10 Wonderful (1001) "Great location and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sirbrina CA $122 CA $136 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Crystal-River-Hotels-Comfort-Suites-Near-Rainbow-Springs.h12704476.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/d9964af7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/5e8d5ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/daecd7e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/c4df473c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta by Wyndham Gainesville [](https://www.expedia.ca/Gainesville-Hotels-La-Quinta-By-Wyndham-Gainesville.h37760006.Hotel-Information) Gainesville 9.0/10 Wonderful (1140) "Very clean hotel and the breakfast was outstanding. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $122 CA $137 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Gainesville-Hotels-La-Quinta-By-Wyndham-Gainesville.h37760006.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/893e3583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/89f48c41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/cb41e4e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Live Oak by IHG [](https://www.expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) Live Oak 8.4/10 Very good (776) "Have stayed here whenever we are in town. Always god stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregg CA $165 CA $182 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/0124d3bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/d39ee4a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/45cc4db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lake City [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) Lake City 9.4/10 Exceptional (1000) "Clean room, staff, everyone super helpful ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Devang CA $160 CA $180 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) ![Deluxe Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/07c3ba53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/6adfb804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/2f0849f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/d639db90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOM Hotel Gainesville, SureStay Collection by Best Western [](https://www.expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) Gainesville 8.4/10 Very good (1801) "Awesome place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aristeo CA $104 CA $117 total includes taxes & fees Jan 26 - Jan 27, 2026 [](https://www.expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/e387508a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/f5784012.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/9c7b0262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/abd6d373.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Gainesville, FL [](https://www.expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) Gainesville 9.2/10 Wonderful (1631) "Quiet and clean overnight stay, we will be back , breakfast was good . " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ralph CA $125 CA $141 total includes taxes & fees Jan 25 - Jan 26, 2026 [](https://www.expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/cba0289f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/41454f4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/e8bf5c2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites University/Shands [](https://www.expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) Gainesville 8.8/10 Excellent (1051) "Clean room and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $101 CA $121 total includes taxes & fees Jan 9 - Jan 10, 2026 [](https://www.expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/f5ec1000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/1240f4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/dc8aa87c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Lake City [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) Lake City 9.2/10 Wonderful (1025) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack CA $130 CA $146 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/7f945643.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/c94f1402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/695b0a91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/4977ae81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Lake City [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) Lake City 9.6/10 Exceptional (1000) "Great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alison CA $147 CA $165 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/8ea1560b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Accessible](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/a06a7172.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/0fcdbbf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/d868e6f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Equus Inn Ocala [](https://www.expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) Ocala 9.0/10 Wonderful (1777) "We had a good stay , the breakfast is a lifesaver " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) arlet CA $114 CA $127 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-14&endDate=2026-01-15®ionId=6233773&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top North Central Florida Hotel Reviews ![Drury Inn & Suites Gainesville](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/93f8f773_y.jpg) ### Drury Inn & Suites Gainesville 10/10 Excellent " Everything about the Drury Inn is great. " [](https://expedia.ca/Gainesville-Hotels-Drury-Inn-Suites-Gainesville.h19484503.Hotel-Information) ![Best Western Ocala Park Centre](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/fbb41ad1_y.jpg) ### Best Western Ocala Park Centre 10/10 Excellent "Breakfast" [](https://expedia.ca/Ocala-Hotels-Best-Western-Ocala-Park-Centre.h429339.Hotel-Information) ![Best Western Gateway Grand](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/9a241e09_y.jpg) ### Best Western Gateway Grand 10/10 Excellent "The room was clean, spacious and comfortable!! We loved enjoying the hot tub at night and the bath towels were some of the softest and nicest quality I have ever had at a hotel. Also, don’t skip the free breakfast! They had a lot of great options and they were actually flavorful and of good quality!" [](https://expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) ![Sleep Inn & Suites University/Shands](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9_y.jpg) ### Sleep Inn & Suites University/Shands 10/10 Excellent "Safe parking " [](https://expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![Country Inn & Suites by Radisson, Gainesville, FL](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/8584a629_y.jpg) ### Country Inn & Suites by Radisson, Gainesville, FL 10/10 Excellent "Highly Recommend " [](https://expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Howard Johnson by Wyndham Ocala FL I-75](https://images.trvl-media.com/lodging/1000000/50000/41500/41471/40bf238e_y.jpg) ### Howard Johnson by Wyndham Ocala FL I-75 10/10 Excellent "Shopped around quite a bit before settling on Howard Johnson. Best deal! The staff was friendly, rooms were clean, beds were comfortable, and the breakfast was about what you'd expect for that price. After a long day kayaking Silver Springs the hot tub was a perfect way to end the day. " [](https://expedia.ca/Ocala-Hotels-Howard-Johnson-By-Wyndham-Ocala-FL.h41471.Hotel-Information) ![Equus Inn Ocala](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/8ea1560b_y.jpg) ### Equus Inn Ocala 10/10 Excellent "Clean and comfortable, good breakfast and location. Very reasonable rate and great location." [](https://expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) ![Comfort Inn University](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85_y.jpg) ### Comfort Inn University 10/10 Excellent "It’s ok" [](https://expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ![DoubleTree by Hilton Gainesville](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/ff7eaa86_y.jpg) ### DoubleTree by Hilton Gainesville 10/10 Excellent "Check in was easy and we were greeted by Sierra who gave us Hotel info including breakfast and coffee. Lobby was decorated for Christmas and it was lovely. " [](https://expedia.ca/Gainesville-Hotels-DoubleTree-By-Hilton-Gainesville.h49617.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in North Central Florida cost? ### What are the best business-friendly hotels in North Central Florida? ### How many business-friendly hotels are there in North Central Florida? ### What are the best cheap business-friendly hotels in North Central Florida? ### Are there any family-friendly hotels in North Central Florida that are also business friendly? ### Why book your business-friendly hotel in North Central Florida with Expedia? ### How can I find cheap business-friendly hotels in North Central Florida? ### What is there to do in North Central Florida near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Green Hotels in Daytona Beach ](https://www.expedia.ca/Daytona-Beach-Hotels-Green-Sustainable.0-0-d6023995-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in Daytona Beach ](https://www.expedia.ca/Daytona-Beach-Hotels-Honeymoon-Hotels.0-0-d6023995-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - 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