Title: New Madrid Vacation Home Rentals from CA $410: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in New Madrid](https://expedia.ca/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels)[Vacation Rentals in New Madrid](https://expedia.ca/New-Madrid-Vacation-Rentals.d3000445315.Travel-Guide-VacationRentals)[New Madrid Car Rentals](https://expedia.ca/Car-Rentals-In-New-Madrid.d3000445315.Car-Rental-Guide)[New Madrid Vacation Packages](https://expedia.ca/New-Madrid.d3000445315.Destination-Travel-Guides) ![Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. . ](https://images.trvl-media.com/place/3000445315/970b11d9-266d-426a-9577-5e745e0939b7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # New Madrid Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=3000445315&startDate=2025-12-26&endDate=2025-12-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=3000445315&startDate=2026-02-06&endDate=2026-02-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=3000445315&startDate=2026-03-06&endDate=2026-03-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=3000445315&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for New Madrid vacation homes ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1080h1439x0y1-2bafdfca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1060h720x0y199-6f809fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1080h719x0y1-5e759738.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1050h1619x0y1-13beb152.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in New Madrid [](https://www.expedia.ca/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information) 10/10 Exceptional (1) "The host was very quick to respond and so great to work with for on our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica S. CA $222 CA $411 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/8a25ec43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/5a8fdf84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/0fb68382.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/c8f80adb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Tiptonville [](https://www.expedia.ca/Tiptonville-Hotels-Sunkist-Beach-House-Lake-Side-House-3-Bedroom-House.h102510923.Hotel-Information) 10/10 Exceptional (4) "The house was nice and clean and had every thing on hand that we needed. The host was excellent to deal with. We would definitely stay here again. It’s in a nice quiet neighborhood and the kids enjoyed the park that’s right down the road. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deanna P. CA $312 CA $504 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Tiptonville-Hotels-Sunkist-Beach-House-Lake-Side-House-3-Bedroom-House.h102510923.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-24&endDate=2025-12-25®ionId=3000445315&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FNew-Madrid-Private-Vacation-Homes.d3000445315-aaPrivateVacationHomes.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FNew-Madrid-Private-Vacation-Homes.d3000445315-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top New Madrid Hotel Reviews ![New Orleans Inn Portageville ](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg) ### New Orleans Inn Portageville 10/10 Excellent "Rooms were clean and staff was friendly!" [](https://expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Very clean room. Great breakfast and polite staff." [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf_y.jpg) ### Fairfield Inn & Suites by Marriott Sikeston 10/10 Excellent "Staff" [](https://expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da_y.jpg) ### Holiday Inn Express & Suites Sikeston Southwest by IHG 10/10 Excellent "Staff was great. Hotel was clean. Great sleep. " [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/755237c5_y.jpg) ### Reelfoot Lake Inn 10/10 Excellent "Homegate Inn is an older property and there is some noticeable wear and tear on the exterior. My room appears to have been updated recently with new bedding and furniture. Had a nice tv with tons of channels. Heat and air worked very well. Plenty of hot water. Room was very clean and comfortable. Nice desk and chair, tv, large fridge with freezer, coffee maker, dresser, large closet. Bath was clean and nice. Check-in was fast and easy. Owner and staff were friendly and attentive. Reelfoot Lake is directly across the street and is a beautiful area. Dining, gas, shopping is closeby, though it is a small town. This was my second stay and I will stay again, I'm sure. " [](https://expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![Premier lodging at Reelfoot lake , First class upgrade!](https://images.trvl-media.com/lodging/84000000/83510000/83500500/83500478/dbfefe0b_y.jpg) ### Premier lodging at Reelfoot lake , First class upgrade! 10/10 Excellent "Yes, the place was very clean, updated and very comfortable. Jason is a great host, very responsive, nice and informative." [](https://expedia.ca/Hornbeak-Hotels-Premier-Lodging-At-Reelfoot-Lake.h83500478.Hotel-Information) ![Super 8 By Wyndham Marston](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d663210_y.jpg) ### Super 8 By Wyndham Marston 10/10 Excellent "Great staff " [](https://expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) ![Travel Inn](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/501c540f_y.jpg) ### Travel Inn 10/10 Excellent "This motel is on a side road by open fields next to the expressway. The parking lot is large and well lit at night. It felt like a reasonably safe place. The desk clerk was friendly and helpful. The room was clean but a little worse for wear in some ways. The bed was comfortable and the HVAC unit worked well. Breakfast was just coffee, cold cereal and milk. " [](https://expedia.ca/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information) ![Duck Hunting, Fishing or Relaxing Family Vacation](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/09116238_y.jpg) ### Duck Hunting, Fishing or Relaxing Family Vacation 10/10 Excellent "Kitchen had everything you needed beds were comfortable and atmosphere was relaxing" [](https://expedia.ca/Hornbeak-Hotels-Duck-Hunting.h36088974.Hotel-Information) ## Find out more about New Madrid ## New Madrid Vacation Homes information | Number of reviews | 4 | | ----------------- | ----------------- | | Accommodation | 14 Vacation Homes | | Lowest Price | CA $410 | | Highest Price | CA $504 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Apartments in Baker ](https://www.expedia.ca/Baker-Apartments.d553248634983252914-aaApartments.Travel-Guide-Accommodation) - [Apartments in Bell City ](https://www.expedia.ca/Bell-City-Apartments.d553248634983588961-aaApartments.Travel-Guide-Accommodation) - 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