Title: Book the Best Myrtle LUXURY Hotels - Upscale Hotels in Myrtle, MS | Expedia.ca [Hotels in Myrtle](https://expedia.ca/Myrtle-Hotels.d553248635974530535.Travel-Guide-Hotels)[Vacation Rentals in Myrtle](https://expedia.ca/Myrtle-Vacation-Rentals.d553248635974530535.Travel-Guide-VacationRentals)[Myrtle Car Rentals](https://expedia.ca/Car-Rentals-In-Myrtle.d553248635974530535.Car-Rental-Guide)[Myrtle Vacation Packages](https://expedia.ca/Myrtle.d553248635974530535.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Myrtle, MS - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Myrtle Luxury Hotels Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=553248635974530535&startDate=2025-11-04&endDate=2025-11-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=553248635974530535&startDate=2025-11-05&endDate=2025-11-06&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635974530535&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635974530535&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Myrtle Luxury Hotels ## Top Myrtle Hotel Reviews ## Frequently asked questions ### Are you looking for a luxury hotel for your Myrtle vacation? > Expedia can help you get a flight to University, MS (UOX-University - Oxford) airport or Tupelo, MS (TUP-Tupelo Regional) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to get what you want to make your stay special. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Myrtle has to offer. ### When can I expect good weather in Myrtle? > Planning for the weather is an important factor for making your trip to Myrtle a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 78°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Myrtle is 55 inches. ### What's there to see and do in Myrtle? > Enjoy all that Myrtle has to offer and visit Tanglefoot Trail, New Albany City Hall, and Sugaree's Bakery. 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