Title: Book the Best Murex Lakes SPA Resorts - Spa Hotels in Murex Lakes, Sanibel | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Murex Lakes Car Rentals](https://expedia.ca/Car-Rentals-In-Murex-Lakes.d553248635976468770.Car-Rental-Guide)[Murex Lakes Vacations](https://expedia.ca/Murex-Lakes.d553248635976468770.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Murex Lakes, Sanibel ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Murex Lakes Spa Hotels Tonight [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-09-28&endDate=2025-09-29&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-09-29&endDate=2025-09-30&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Murex Lakes Spa Hotels ![A heated pool](https://images.trvl-media.com/lodging/100000000/99430000/99425100/99425020/02751187.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/100000000/99430000/99425100/99425020/c040a544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99430000/99425100/99425020/126bac5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99430000/99425100/99425020/a903e5cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious 3/2 pool home on Sanibel Island | 10 min walk to beach - Lily Pad Murex Lakes 10/10 Exceptional (1) "The property is better than it appears in pictures. In addition, it is more than sufficiently well supplied and not only in the kitchen. We would have appreciated if we had known beforehand that there were 5 bicycles available, 3 beach coolers, a beach cart to take the stuff to the beach, beach chairs and even beach toys. We did not use these as we brought our bikes, beach cart, beach chairs and umbrellas but it would have saved expense and room. It is also not advertised that the house is at... [](https://www.expedia.ca/Sanibel-Hotels-Private-Pool.h99425020.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/69000000/68690000/68687000/68686960/06e44506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/69000000/68690000/68687000/68686960/27879299.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/69000000/68690000/68687000/68686960/36c2aa00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![A heated pool](https://images.trvl-media.com/lodging/69000000/68690000/68687000/68686960/6550d554.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urlaub Haus, Beautifully Remodeled, Lake-Front Pool Home Murex Lakes 10/10 Exceptional (6) "Rating Details: The property manager was very helpful. The vacation rental was spotless. I was very happy with the location. I was very satisfied with the condition of the vacation rental. Overall, I recommend this vacation rental. Reviewer Comments: The perfectl home in the most perfect location With an amazing view of the lake and the sunset. Close to the beach, shops, restaurants but tranquility is what this home is about!!!" [](https://www.expedia.ca/Sanibel-Hotels-Urlaub-Haus.h68686960.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/101830000/101826500/101826469/w904h683x60y0-ceb99384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/102000000/101830000/101826500/101826469/w1024h676x0y3-c6e04a79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101830000/101826500/101826469/w1024h676x0y4-c3130ab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/102000000/101830000/101826500/101826469/w905h683x60y0-75dccf4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beach Walk Haven Murex Lakes [](https://www.expedia.ca/Sanibel-Hotels-Beach-Walk-Haven.h101826469.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-12&endDate=2025-10-13®ionId=553248635976468770&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Murex Lakes Hotel Reviews ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent "Overall very pleasant experience " [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "Newly renovated property just finishing the last upgrades like new exterior tiles. Lobby was spacious, staff helpful & check in prompt. Room was newly upgraded, excellent WiFi, great pool and breakfast was outstanding continental with hot options like sausages, scrambled egg, omelettes and waffle maker. Overall a great stay and would stay again." [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "Great location. " [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "Great place to stay. Town is a 10 minute walk with Tram and golf cart if you prefer not to walk. Events for the kids every morning. Italian restaurant on property is delicious. Plenty of other food options so you don’t need to leave. " [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Hilton Garden Inn Ft Myers](//images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "Safe, quiet, and clean" [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ![Homewood Suites by Hilton - Fort Myers](//images.trvl-media.com/lodging/1000000/70000/63300/63247/6feb2ef6_y.jpg) ### Homewood Suites by Hilton - Fort Myers 10/10 Excellent "Breakfast was phenomenal. Very clean hotel, it has everything you could ever want or need to offer. Very friendly staff also." [](https://expedia.ca/Fort-Myers-Hotels-Homewood-Suites-By-Hilton-Fort-Myers.h63247.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "Top notch resort with amazing pool and bayfront views of Sanibel!" [](https://expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Hyatt Vacation Club at Coconut Cove, Bonita Springs](//images.trvl-media.com/lodging/1000000/1000000/991200/991114/7c494168_y.jpg) ### Hyatt Vacation Club at Coconut Cove, Bonita Springs 10/10 Excellent "Everything was perfect " [](https://expedia.ca/Bonita-Springs-Hotels-Hyatt-Vacation-Club-At-Coconut-Cove.h991114.Hotel-Information) ![Hyatt Regency Coconut Point Resort & Spa](//images.trvl-media.com/lodging/1000000/800000/792100/792025/311e3874_y.jpg) ### Hyatt Regency Coconut Point Resort & Spa 10/10 Excellent "We always love our stays at The Hyatt Regency Coconut Point. The rooms are great, the staff is super friendly and accommodating, food and drink are on point. The pools and slides are so fun and the property has so many extras and fun environments to explore. " [](https://expedia.ca/Naples-Hotels-Hyatt-Regency-Coconut-Point-Resort-Spa.h792025.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Murex Lakes? > Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Spa hotels are the perfect way to take a break from your daily routine and add a layer of luxury to your weekend away. ### What's there to see and do in Murex Lakes? > Enjoy Murex Lakes with a stop at Key West Express, Sanibel Island Southern Beach, and J. N. Ding Darling National Wildlife Refuge. If you have extra time while you're in the area, you might want to stop by Periwinkle Way and Bowman's Beach. ### What is a Murex Lakes spa hotel? > Spa hotels in Murex Lakes feature on-site spas which offer services including massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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