Title: Book the Best Murex Lakes LUXURY Hotels - Upscale Hotels in Murex Lakes, Sanibel | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Murex Lakes Car Rentals](https://expedia.ca/Car-Rentals-In-Murex-Lakes.d553248635976468770.Car-Rental-Guide)[Murex Lakes Vacations](https://expedia.ca/Murex-Lakes.d553248635976468770.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Murex Lakes, Sanibel ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Murex Lakes Luxury Hotels Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-10-13&endDate=2025-10-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-10-14&endDate=2025-10-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976468770&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Murex Lakes Luxury Hotels ## Top Murex Lakes Hotel Reviews ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent " Nice, large room. This hotel on the beach has everything: on the beach, great views, nice pool/hot tubs, food/bar, and some entertainment. Needs a sit down breakfast option." [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![The Westin Cape Coral Resort At Marina Village](//images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e_y.jpg) ### The Westin Cape Coral Resort At Marina Village 10/10 Excellent "Great space and great location. Staff extremely helpful." [](https://expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![Lani Kai Beachfront Resort](//images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Property Is all new however still some construction" [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "Very satisfied with the hotel, amenities and our stay. We will be back! " [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![The Lighthouse Resort Inn & Suites](//images.trvl-media.com/lodging/1000000/810000/800800/800715/w2800h1779x0y3-dbc2bfa3_y.jpg) ### The Lighthouse Resort Inn & Suites 10/10 Excellent "our first time staying at the lighthouse . we really enjoyed our stay and actually extended one more nite , and have already booked another stay. sad to see all the extended damage from storm's But we found a new location to visit . We LOVE ft.Myers Beach " [](https://expedia.ca/Fort-Myers-Hotels-The-Lighthouse-Resort-Inn-Suites.h800715.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "The time at the pool was amazing. Really nice views from the room" [](https://expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "Friendly staff. Good location close to Sanibel Island." [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Baymont by Wyndham Fort Myers Central](//images.trvl-media.com/lodging/1000000/30000/23400/23367/7ff8face_y.jpg) ### Baymont by Wyndham Fort Myers Central 8/10 Good "The room did not look like the picture. And the bed is not comfortable. The room had a musty smell. And the bathroom is super small. The grounds of the property are well-maintained. But the rooms you can tell are old and painted to look better. " [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-By-Wyndham-Fort-Myers-Central.h23367.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury holiday in Murex Lakes? > Use Expedia to arrange your flight to Southwest Florida Intl. Airport (RSW) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Murex Lakes has to offer. ### What's there to see and do in Murex Lakes? > When you're in Murex Lakes, enjoy exploring the sights and attractions here including Key West Express, Sanibel Island Southern Beach, and J. N. Ding Darling National Wildlife Refuge. 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