Title: Book the Best Moss Creek Adults Only Resorts & Hotels in 2025 | Expedia.ca [Moss Creek Travel Guide](https://expedia.ca/Hilton-Head-Island-Moss-Creek.dx553248635976475966)[Vacation Rentals in Hilton Head Island](https://expedia.ca/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals)[Flights to Hilton Head Island](https://expedia.ca/Cheap-Flights-To-Hilton-Head-Island.d601684.Travel-Guide-Flights)[Things to do in Hilton Head Island](https://expedia.ca/Things-To-Do-In-Hilton-Head-Island.d601684.Travel-Guide-Activities)[Moss Creek Car Rentals](https://expedia.ca/Car-Rentals-In-Moss-Creek.d553248635976475966.Car-Rental-Guide)[Moss Creek Vacations](https://expedia.ca/Moss-Creek.d553248635976475966.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Adults Only Resorts & Hotels in Moss Creek, SC ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Moss Creek Adults Only Resorts & Hotels Tonight [Sep 21 - Sep 22](https://www.expedia.ca/Hotel-Search?regionId=553248635976475966&startDate=2025-09-21&endDate=2025-09-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 22 - Sep 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976475966&startDate=2025-09-22&endDate=2025-09-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976475966&startDate=2025-09-26&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976475966&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Moss Creek Adults Only Resorts & Hotels ## Find out more about Moss Creek ### Discover top Moss Creek attractions Nestled in the serene Moss Creek neighbourhood, travellers can indulge in a variety of activities that beautifully blend relaxation and adventure. Start your day with a round of golf at the prestigious Moss Creek Golf Club, where the picturesque fairways and stunning water views create a perfect backdrop for both novice and seasoned players. For families, the nearby Coastal Discovery Museum offers interactive exhibits that engage children and adults alike, providing a fun and educational experience about the natural history of the Lowcountry. If you seek outdoor escapades, take advantage of the scenic trails at the Moss Creek Nature Preserve, ideal for hiking, birdwatching, or simply enjoying a peaceful stroll amid lush greenery. As the day winds down, enjoy a sunset cruise along the Intracoastal Waterway, where you can witness the vibrant colours reflecting off the water while spotting local wildlife. After a day of exploration, the hotels in Moss Creek, such as the luxurious Moss Creek Villas, offer spacious rooms with private balconies and stunning views, ensuring you unwind in comfort. With attentive staff dedicated to pampering your every need, you can enjoy a seamless blend of leisure and luxury, making your stay as memorable as the adventures that await outside your door. ## Top Moss Creek Hotel Reviews ![Omni Hilton Head Oceanfront Resort](//images.trvl-media.com/lodging/1000000/20000/14700/14690/c13a70d7_y.jpg) ### Omni Hilton Head Oceanfront Resort 10/10 Excellent "Excellent food" [](https://expedia.ca/Hilton-Head-Hotels-Omni-Hilton-Head-Oceanfront-Resort.h14690.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [4 Star Hotels in Windmill Harbor](https://www.expedia.ca/4Star-Windmill-Harbor-Hotels.s40-0-d553248635975850995.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Colleton River](https://www.expedia.ca/5Star-Colleton-River-Bluffton-Hotels.s50-n553248635976469811-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Westbury Park](https://www.expedia.ca/5Star-Westbury-Park-Bluffton-Hotels.s50-n553248635976474845-0.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Belfair](https://www.expedia.ca/Belfair-Bluffton-Hotels-All-Inclusive-Hotel.0-n553248635976480986-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Belfair](https://www.expedia.ca/Belfair-Bluffton-Hotels-Pet-Friendly-Hotel.0-n553248635976480986-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Aparthotels in Bluffton](https://www.expedia.ca/Bluffton-Apart-Hotels.d602237-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Bluffton](https://www.expedia.ca/Bluffton-Bed-And-Breakfast.d602237-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Condo Resorts in Bluffton](https://www.expedia.ca/Bluffton-Condominium-Resort.d602237-aaCondominiumResort.Travel-Guide-Accommodation) - [Adults Only Resorts & in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Adults-Only-Resorts.0-0-d602237-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Cheap-Hotels.0-0-d602237-tCheapHotels.Travel-Guide-Filter-Hotels) - [Golf Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Golf-Hotel.0-0-d602237-tGolfHotel.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Hotels-With-Kitchenettes.0-0-d602237-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Luxury-Hotel.0-0-d602237-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Oceanfront-Hotels.0-0-d602237-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Pet-Friendly-Hotel.0-0-d602237-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Spa-Hotel.0-0-d602237-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Waterpark-Hotels.0-0-d602237-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Hotel Wedding Venues Hotels in Bluffton](https://www.expedia.ca/Bluffton-Hotels-Wedding-Hotels.0-0-d602237-tWeddingHotels.Travel-Guide-Filter-Hotels) - [Bluffton Hotels](https://www.expedia.ca/Bluffton-Hotels.d602237.Travel-Guide-Hotels) - [Inns in Bluffton](https://www.expedia.ca/Bluffton-Inns.d602237-aaInns.Travel-Guide-Accommodation) - [Lodges in Bluffton](https://www.expedia.ca/Bluffton-Lodges.d602237-aaLodges.Travel-Guide-Accommodation) - [Motels in Bluffton](https://www.expedia.ca/Bluffton-Motels.d602237-aaMotels.Travel-Guide-Accommodation) - [Townhomes in Bluffton](https://www.expedia.ca/Bluffton-Townhomes.d602237-aaTownhomes.Travel-Guide-Accommodation) - [Beach Hotel Hotels in Buckingham Landing](https://www.expedia.ca/Buckingham-Landing-Bluffton-Hotels-Beach-Hotel.0-n553248635976480141-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Buckingham Landing Hotels](https://www.expedia.ca/Buckingham-Landing-Bluffton-Hotels.0-n553248635976480141-0.Travel-Guide-Filter-Hotels) - [Cabin Rentals in Callawassie Island](https://www.expedia.ca/Callawassie-Island-Cabins.d553248635975749022-aaCabins.Travel-Guide-Accommodation) - [Resorts in Callawassie Island](https://www.expedia.ca/Callawassie-Island-Resort-Hotels.d553248635975749022-aaResortHotels.Travel-Guide-Accommodation) - [Business Hotels in Charleston](https://www.expedia.ca/Charleston-Hotels-Business-Hotel.0-0-d179997-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Green Hotels in Charleston](https://www.expedia.ca/Charleston-Hotels-Green-Sustainable.0-0-d179997-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Charleston](https://www.expedia.ca/Charleston-Hotels-Hotel-With-Early-Check-In.0-0-d179997-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Hotels with a Lazy River in Charleston](https://www.expedia.ca/Charleston-Hotels-Hotels-With-A-Lazy-River.0-0-d179997-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels) - [Hotels near Coastal Discovery Museum](https://www.expedia.ca/Coastal-Discovery-Museum-Hotels.0-l6082729-0.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Colleton River](https://www.expedia.ca/Colleton-River-Bluffton-Hotels-Beach-Hotel.0-n553248635976469811-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Crescent](https://www.expedia.ca/Crescent-Bluffton-Hotels-Beach-Hotel.0-n553248635976481849-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Crescent](https://www.expedia.ca/Crescent-Bluffton-Hotels-Couples-Resorts-Hotels.0-n553248635976481849-0-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Crescent Hotels](https://www.expedia.ca/Crescent-Bluffton-Hotels.0-n553248635976481849-0.Travel-Guide-Filter-Hotels) - [Eagle's Pointe Hotels](https://www.expedia.ca/Eagles-Pointe-Bluffton-Hotels.0-n553248635976480317-0.Travel-Guide-Filter-Hotels) - [Hilton Head Island Hotels](https://www.expedia.ca/Hilton-Head-Island-Hotels.d601684.Travel-Guide-Hotels) - [Houseboats in Hilton Head Plantation](https://www.expedia.ca/Hilton-Head-Plantation-Houseboats.d553248635975851728-aaHouseboats.Travel-Guide-Accommodation) - [B&B in Indigo Run](https://www.expedia.ca/Indigo-Run-Bed-And-Breakfast.d553248635975867127-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Townhomes in Indigo Run](https://www.expedia.ca/Indigo-Run-Townhomes.d553248635975867127-aaTownhomes.Travel-Guide-Accommodation) - [Hotels near May River Golf Club at Palmetto Bluff](https://www.expedia.ca/May-River-Golf-Club-At-Palmetto-Bluff-Hotels.0-l6299934-0.Travel-Guide-Filter-Hotels) - [Mid Island Hotels](https://www.expedia.ca/Mid-Island-Hilton-Head-Island-Hotels.0-n904314885436178432-0.Travel-Guide-Filter-Hotels) - [Hotels with Bar in North End](https://www.expedia.ca/North-End-Hilton-Head-Island-Hotels-Hotels-With-Bar.0-n904315600885886976-0-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Palmetto Bluff](https://www.expedia.ca/Palmetto-Bluff-Bluffton-Hotels-Adults-Only-Resorts.0-n553248635074842419-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Palmetto Bluff](https://www.expedia.ca/Palmetto-Bluff-Bluffton-Hotels-All-Inclusive-Hotel.0-n553248635074842419-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Palmetto Bluff](https://www.expedia.ca/Palmetto-Bluff-Bluffton-Hotels-Casino-Hotel.0-n553248635074842419-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Palmetto Bluff](https://www.expedia.ca/Palmetto-Bluff-Bluffton-Hotels-Pet-Friendly-Hotel.0-n553248635074842419-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels near Palmetto Hall Golf and Country Club](https://www.expedia.ca/Palmetto-Hall-Golf-And-Country-Club-Hotels.0-l6300034-0.Travel-Guide-Filter-Hotels) - [Farmstay in Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Pinckney-Island-National-Wildlife-Refuge-Agritourism.d6082737-aaAgritourism.Travel-Guide-Accommodation) - [Condo Rentals in Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Pinckney-Island-National-Wildlife-Refuge-Condos.d6082737-aaCondos.Travel-Guide-Accommodation) - [Cheap Hotels in Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Pinckney-Island-National-Wildlife-Refuge-Hotels-Cheap-Hotels.0-0-d6082737-tCheapHotels.Travel-Guide-Filter-Hotels) - [Pinckney Island National Wildlife Refuge Hotels](https://www.expedia.ca/Pinckney-Island-National-Wildlife-Refuge-Hotels.d6082737.Travel-Guide-Hotels) - [Inns in Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Pinckney-Island-National-Wildlife-Refuge-Inns.d6082737-aaInns.Travel-Guide-Accommodation) - [Rv Parks in Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Pinckney-Island-National-Wildlife-Refuge-RV-Parks.d6082737-aaRVParks.Travel-Guide-Accommodation) - [Treehouses in Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Pinckney-Island-National-Wildlife-Refuge-Treehouses.d6082737-aaTreehouses.Travel-Guide-Accommodation) - [Hotels with Kitchenettes in Rose Hill](https://www.expedia.ca/Rose-Hill-Bluffton-Hotels-Hotels-With-Kitchenettes.0-n553248635976473228-0-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Hotel Wedding Venues Hotels in Rose Hill](https://www.expedia.ca/Rose-Hill-Bluffton-Hotels-Wedding-Hotels.0-n553248635976473228-0-tWeddingHotels.Travel-Guide-Filter-Hotels) - [Rose Hill Hotels](https://www.expedia.ca/Rose-Hill-Bluffton-Hotels.0-n553248635976473228-0.Travel-Guide-Filter-Hotels) - [Hotels near Rose Hill Golf Club](https://www.expedia.ca/Rose-Hill-Golf-Club-Hotels.0-l6300049-0.Travel-Guide-Filter-Hotels) - [Hotels near Rose Hill Mansion](https://www.expedia.ca/Rose-Hill-Mansion-Hotels.0-l6300944-0.Travel-Guide-Filter-Hotels) - [Hotels near Shelter Cove Harbour](https://www.expedia.ca/Shelter-Cove-Harbour-Hotels.0-l6301000-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Spanish Wells](https://www.expedia.ca/Spanish-Wells-Hilton-Head-Island-Hotels-Boutique-Hotel.0-n553248635976481270-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Spanish Wells Hotels](https://www.expedia.ca/Spanish-Wells-Hilton-Head-Island-Hotels.0-n553248635976481270-0.Travel-Guide-Filter-Hotels) - [Hotels near Tanger Outlets Hilton Head](https://www.expedia.ca/Tanger-Outlets-Hilton-Head-Hotels.0-l6300442-0.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Westbury Park](https://www.expedia.ca/Westbury-Park-Bluffton-Hotels-All-Inclusive-Hotel.0-n553248635976474845-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Westbury Park](https://www.expedia.ca/Westbury-Park-Bluffton-Hotels-Hotels-With-Kitchenettes.0-n553248635976474845-0-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Westbury Park](https://www.expedia.ca/Westbury-Park-Bluffton-Hotels-Luxury-Hotel.0-n553248635976474845-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Westbury Park](https://www.expedia.ca/Westbury-Park-Bluffton-Hotels-Romantic-Hotel.0-n553248635976474845-0-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Westbury Park](https://www.expedia.ca/Westbury-Park-Bluffton-Hotels-Waterpark-Hotels.0-n553248635976474845-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Flights to Bluffton](https://www.expedia.ca/Cheap-Flights-To-Bluffton.d602237.Travel-Guide-Flights) - [Flights to Callawassie Island](https://www.expedia.ca/Cheap-Flights-To-Callawassie-Island.d553248635975749022.Travel-Guide-Flights) - [Flights to Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Cheap-Flights-To-Pinckney-Island-National-Wildlife-Refuge.d6082737.Travel-Guide-Flights) - [Flights from Bluffton](https://www.expedia.ca/lp/flights/602237/flights-from-bluffton) - [Flights from Atlanta (ATL) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/atl/hhh/atlanta-to-hilton-head-island) - [Flights from Buffalo (BUF) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/buf/hhh/buffalo-to-hilton-head-island) - [Flights from Charlotte (CLT) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/clt/hhh/charlotte-to-hilton-head-island) - [Flights from Detroit (DTW) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/dtw/hhh/detroit-to-hilton-head-island) - [Flights from Niagara Falls (IAG) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/iag/hhh/niagara-falls-to-hilton-head-island) - [Flights from Orlando (MCO) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/mco/hhh/orlando-to-hilton-head-island) - [Flights from Savannah (SAV) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/sav/hhh/savannah-to-hilton-head-island) - [Flights from Syracuse (SYR) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/syr/hhh/syracuse-to-hilton-head-island) - [Flights from Hamilton (YHM) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yhm/hhh/hamilton-to-hilton-head-island) - [Flights from Halifax (YHZ) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yhz/hhh/halifax-to-hilton-head-island) - [Flights from Kitchener (YKF) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/ykf/hhh/kitchener-to-hilton-head-island) - [Flights from Ottawa (YOW) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yow/hhh/ottawa-to-hilton-head-island) - [Flights from Toronto (YTZ) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/ytz/hhh/toronto-to-hilton-head-island) - [Flights from Montreal (YUL) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yul/hhh/montreal-to-hilton-head-island) - [Flights from Vancouver (YVR) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yvr/hhh/vancouver-to-hilton-head-island) - [Flights from London (YXU) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yxu/hhh/london-to-hilton-head-island) - [Flights from Calgary (YYC) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yyc/hhh/calgary-to-hilton-head-island) - [Flights from Toronto (YYZ) to Hilton Head Island (HHH)](https://www.expedia.ca/lp/flights/yyz/hhh/toronto-to-hilton-head-island) - [Brighton Beach Vacations](https://www.expedia.ca/Brighton-Beach.d553248635975872557.Destination-Travel-Guides) - [Callawassie Island Vacations](https://www.expedia.ca/Callawassie-Island.d553248635975749022.Destination-Travel-Guides) - [Golden Bear Golf Club](https://www.expedia.ca/Golden-Bear-Golf-Club-Mid-Island.d6299903.Vacation-Attraction) - [Visit Indigo Run](https://www.expedia.ca/Indigo-Run.dx553248635975867127) - [Rose Hill Golf Club](https://www.expedia.ca/Rose-Hill-Golf-Club-Rose-Hill.d6300049.Vacation-Attraction) - [Car rental Bluffton](https://www.expedia.ca/Car-Rentals-In-Bluffton.d602237.Car-Rental-Guide) - [Redspot Rental Cars in Pinckney Island National Wildlife Refuge](https://www.expedia.ca/Redspot-Car-Rentals-In-Pinckney-Island-National-Wildlife-Refuge.d6082737-c1078.Car-Rental-Guide-Suppliers) - [Bluffton Vacation Rentals](https://www.expedia.ca/Bluffton-Vacation-Rentals.d602237.Travel-Guide-VacationRentals) - [Book Hotels in Moss Creek on Expedia.com](https://www.expedia.com/Moss-Creek-Hilton-Head-Hotels-Adults-Only-Resorts.0-n553248635976475966-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)