Title: Book the Best Mosel Wine Region LUXURY Hotels - Upscale Hotels in Mosel Wine Region | Expedia.ca [Mosel Wine Region Travel Guide](https://expedia.ca/Mosel-Wine-Region.dx553248621593537217)[Hotels in Mosel Wine Region](https://expedia.ca/Mosel-Wine-Region-Hotels.d553248621593537217.Travel-Guide-Hotels)[Vacation Rentals in Mosel Wine Region](https://expedia.ca/Mosel-Wine-Region-Vacation-Rentals.d553248621593537217.Travel-Guide-VacationRentals)[Flights to Mosel Wine Region](https://expedia.ca/Cheap-Flights-To-Mosel-Wine-Region.d553248621593537217.Travel-Guide-Flights)[Mosel Wine Region Car Rentals](https://expedia.ca/Car-Rentals-In-Mosel-Wine-Region.d553248621593537217.Car-Rental-Guide)[Mosel Wine Region Vacation Packages](https://expedia.ca/Mosel-Wine-Region.d553248621593537217.Destination-Travel-Guides) ![Deutsches Eck](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/221000/221307-Rhineland-Palatinate.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Mosel Wine Region ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mosel Wine Region Luxury Hotels Tonight [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248621593537217&startDate=2025-10-19&endDate=2025-10-20&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=553248621593537217&startDate=2025-10-20&endDate=2025-10-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248621593537217&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248621593537217&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Mosel Wine Region Luxury Hotels ## Top Mosel Wine Region Hotel Reviews ## Explore a world of travel with Expedia - 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