Title: Book the Best Mission Valley SPA Resorts from CA $149 - Spa Hotels in Mission Valley, San Diego | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Mission Valley Car Rentals](https://expedia.ca/Car-Rentals-In-Mission-Valley.d800124.Car-Rental-Guide)[Mission Valley Vacations](https://expedia.ca/Mission-Valley.d800124.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/c9e921ee48ed278ba029d508e2d24762.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Mission Valley, San Diego from CA $149 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission Valley Spa Hotels Tonight [Sep 20 - Sep 21](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-09-20&endDate=2025-09-21&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 21 - Sep 22](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-09-21&endDate=2025-09-22&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-09-26&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mission Valley Spa Hotels ## Our top choices for Mission Valley hotels with a spa ![Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/ade03197.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/91baa1e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/a5cb77af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Marina Gateway Hotel National City 9.2/10 Wonderful (3301) "Good place to stay" CA $185 CA $204 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Fitness studio](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/8d3908bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/7910f1d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/91cdc1c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/250333ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort El Cajon 9.2/10 Wonderful (1538) "Great hotel " CA $159 CA $192 total includes taxes & fees Sep 23 - Sep 24 [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Aromatherapy, deep-tissue massages, facials, massages](https://images.trvl-media.com/lodging/1000000/20000/11600/11557/81fb96e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11600/11557/3e1e3d44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11600/11557/8e948c08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/11600/11557/ef79bada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Indigo San Diego Del Mar by IHG Del Mar 8.6/10 Excellent (1000) "Good location " CA $252 CA $286 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Del-Mar-Hotels-Hotel-Indigo-San-Diego-Del-Mar.h11557.Hotel-Information) ![Premier Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/fde0003f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/6257cb78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/cc4883a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Handlery Hotel Mission Valley 8.2/10 Very good (2089) "The hotel is really comfortable and in a great location." CA $130 CA $149 total includes taxes & fees Sep 23 - Sep 24 [](https://www.expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Couples treatment rooms, body treatments, hot stone massages](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/cba9a8a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/7442075b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa Mission Valley 9.2/10 Wonderful (2867) "Amazing place to stay. " CA $201 CA $231 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Estate Pool View King | Room amenity](https://images.trvl-media.com/lodging/1000000/990000/983700/983628/da2afcdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/990000/983700/983628/9e1c644b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor wedding](https://images.trvl-media.com/lodging/1000000/990000/983700/983628/7117b683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983628/d03dd77d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Estancia La Jolla Hotel & Spa La Jolla Farms 9.0/10 Wonderful (277) "Beautiful grounds and the staff were amazing " CA $412 CA $551 total includes taxes & fees Sep 21 - Sep 22 [](https://www.expedia.ca/La-Jolla-Hotels-Estancia-La-Jolla-Hotel-Spa.h983628.Hotel-Information) ![Couples treatment rooms, sauna, body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/693784ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/2fa88ae8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/dd10c38e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15600/15525/66a30957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn At Rancho Santa Fe Covenant 9.4/10 Exceptional (125) "Highly recommend a stay here!! Such a beautiful property with incredible amenities!" CA $619 CA $692 total includes taxes & fees Sep 21 - Sep 22 [](https://www.expedia.ca/Rancho-Santa-Fe-Hotels-Inn-At-Rancho-Santa-Fe.h15525.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/7cb5b7d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/98dcc319.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/f0d27d94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/cc6aac5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Humphreys Half Moon Inn Point Loma 9.2/10 Wonderful (2534) "Great front desk staff and beautiful grounds" CA $210 CA $269 total includes taxes & fees Sep 21 - Sep 22 [](https://www.expedia.ca/San-Diego-Hotels-Humphreys-Half-Moon-Inn.h36183.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/5000000/4640000/4632300/4632266/0c2dd430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/5000000/4640000/4632300/4632266/5545e4d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, Multiple Beds, Ocean View | Living area](https://images.trvl-media.com/lodging/5000000/4640000/4632300/4632266/a21ad16d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Ocean View | Terrace/patio](https://images.trvl-media.com/lodging/5000000/4640000/4632300/4632266/0b4eef0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pantai Inn Village of La Jolla 9.4/10 Exceptional (1001) "We love staying here. A one minute walk to shell beach. The free breakfast is bomb. And many great restaurants within walking distance. " CA $375 CA $462 total includes taxes & fees Sep 23 - Sep 24 [](https://www.expedia.ca/La-Jolla-Hotels-Pantai-Inn.h4632266.Hotel-Information) ![Couples treatment rooms, steam room, body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/10000/3100/3007/6984133b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3100/3007/b154db13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Mediterranean cuisine](https://images.trvl-media.com/lodging/1000000/10000/3100/3007/76a62f4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, steam room, body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/10000/3100/3007/07e7eacd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rancho Bernardo Inn Rancho Bernardo 8.8/10 Excellent (1005) "Super friendly staff and great property! " CA $420 CA $542 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/San-Diego-Hotels-Rancho-Bernardo-Inn-San-Diego-A-Golf-And-Spa-Resort.h3007.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-04&endDate=2025-10-05®ionId=800124&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Mission Valley Hotel Reviews ![Bay Club Hotel & Marina](//images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Beautiful " [](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Fun family vacation! Clean, comfy room. So much to do here! Nice staff. The absolute best! Love this place! " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Best Western Inn & Suites San Diego – Zoo/SeaWorld Area ](//images.trvl-media.com/lodging/1000000/50000/40800/40745/a5f33771_y.jpg) ### Best Western Inn & Suites San Diego – Zoo/SeaWorld Area 10/10 Excellent "Clean and friendly front desk worker." [](https://expedia.ca/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "I love the staff that is very kind😇 " [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](//images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Very clean and friendly stuff " [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Crowne Plaza San Diego - Mission Valley by IHG](//images.trvl-media.com/lodging/1000000/580000/571600/571545/f294be65_y.jpg) ### Crowne Plaza San Diego - Mission Valley by IHG 10/10 Excellent "Everything good " [](https://expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Good price and stay " [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Vert nice" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area](//images.trvl-media.com/lodging/1000000/100000/97900/97876/1d354139_y.jpg) ### Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area 10/10 Excellent "Very close to MCRD. Quiet rooms at night " [](https://expedia.ca/San-Diego-Hotels-Homewood-Suites-By-Hilton-San-Diego-Hotel-CircleSeaWorld-Area.h97876.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Mission Valley? > Treat yourself to some pampering and book a hotel with a spa. Travelers love the historical sites and shopping in Mission Valley. Enjoy the museums and beaches during your vacation. Spa hotels are the perfect way to take a break from your daily routine and add a layer of luxury to your holiday. ### What is the best spa hotel in Mission Valley? > [Handlery Hotel](https://www.expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) is a top spa hotel featuring a fitness center, a hair salon, and an outdoor pool. Spend an afternoon at the spa where you'll find facials and massage treatments. Another popular spa hotel in Mission Valley is [Legacy Resort Hotel & Spa](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information). ### How many spa hotels are there in Mission Valley? > Among Expedia's 126 accommodation options in Mission Valley, there are 2 spa hotels. ### What's there to see and do in Mission Valley? > Enjoy all that Mission Valley has to offer and visit Fashion Valley Mall, Snapdragon Stadium, and Mission Valley Mall. If you have extra time while you're in the area, you might want to stop by Riverwalk Golf Club and San Diego Zoo. ### What is a Mission Valley spa hotel? > Spa hotels in Mission Valley have on-site spas which offer services like couples massages and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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