Title: Book the Best BUSINESS Hotels in Mission Valley in 2026 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Mission Valley Car Rentals](https://expedia.ca/Car-Rentals-In-Mission-Valley.d800124.Car-Rental-Guide)[Mission Valley Vacations](https://expedia.ca/Mission-Valley.d800124.Destination-Travel-Guides) ![Closeup of the Adobe walls of the historic Mission De Alcala San Diego California](https://images.trvl-media.com/place/800124/80ddc530-f226-4f74-8ff4-45354a1ef339.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/800124/80ddc530-f226-4f74-8ff4-45354a1ef339.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission Valley Business Hotels Tonight [Jan 24 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2026-01-24&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 25 - Jan 26](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2026-01-25&endDate=2026-01-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Mission Valley business-friendly hotels ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/d3895f6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking, Kitchenette](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/8ec6eafd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 2 Queen Beds, Accessible, Non Smoking (Mobility/Hearing Impaired)](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/30c3ab25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham San Diego Hotel Circle [](https://www.expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) Mission Valley 8.0/10 Very good (2,444 reviews) "I'd stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Flint A CA $109 CA $126 total includes taxes & fees Jan 27 - Jan 28 [](https://www.expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed (High Floor)](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/3d7acad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) Mission Valley 9.2/10 Wonderful (2,942 reviews) "Great relaxing hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher CA $221 CA $254 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/027b3bfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/e4705932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/400/332/9fc85073.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/6ddceb14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel San Diego - Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) Mission Valley 8.4/10 Very good (1,500 reviews) "Staff, rooms, pools, and price..very good! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $184 CA $212 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/48aa6044.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/63c64f0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/71485688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/b4dcb6f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza San Diego - Mission Valley by IHG [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) Mission Valley 8.0/10 Very good (1,022 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Viviann CA $133 CA $153 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-2f0f89f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2557x3y3-6971afdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/5ac99862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Seven Seas [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) Mission Valley 8.0/10 Very good (3,163 reviews) "friendly staff clean room quiet surrounding." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) david CA $96 CA $111 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/18794ebf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/6e469c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Mission Valley 8.0/10 Very good (2,305 reviews) "Amazing stay with effortless check in!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sofia CA $180 CA $207 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/76b95bec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/817b2e14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/7c98a26c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/791e9e65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn San Diego/Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) Mission Valley 8.6/10 Excellent (1,388 reviews) "Great breakfast-comfortable rooms-helpful staff-great location for events" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) bill CA $162 CA $186 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/43ae1d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/605507a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/486f9d1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/6248eb98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Mission Valley/Hotel Circle [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Mission-ValleyHotel-Circle.h1987617.Hotel-Information) Mission Valley 8.4/10 Very good (1,456 reviews) "Nice location, confortable hotel" ![Singapore](https://a.travel-assets.com/egds/marks/flags/sg.svg) Anna Maria CA $177 CA $203 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Mission-ValleyHotel-Circle.h1987617.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/10000000/9310000/9303600/9303562/4313bdb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/10000000/9310000/9303600/9303562/85e4d593.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/10000000/9310000/9303600/9303562/f63e1030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/10000000/9310000/9303600/9303562/9467c4bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites San Diego - Mission Valley by IHG [](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Suites-San-Diego-Mission-Valley.h9303562.Hotel-Information) Mission Valley 8.8/10 Excellent (1,008 reviews) "Very nice hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samer CA $163 CA $191 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Suites-San-Diego-Mission-Valley.h9303562.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/2eb50297.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/363afe83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/8cec183d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Handlery Hotel [](https://www.expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) Mission Valley 8.2/10 Very good (2,289 reviews) "Room was nice, hot tub was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric CA $147 CA $169 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-07&endDate=2026-02-08®ionId=800124&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Mission Valley Hotel Reviews ![DoubleTree by Hilton San Diego - Hotel Circle](https://images.trvl-media.com/lodging/1000000/30000/25600/25536/983f923b_y.jpg) ### DoubleTree by Hilton San Diego - Hotel Circle 10/10 Excellent "Super nice" [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Hotel-Circle.h25536.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "The room was so comfortable and the staff is so kind " [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Outstanding service we loved it and will go back again. " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "The bed was noiceeeee" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 10/10 Excellent "friendly staff clean room quiet surrounding." [](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Courtyard by Marriott San Diego Mission Valley/Hotel Circle](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/43ae1d02_y.jpg) ### Courtyard by Marriott San Diego Mission Valley/Hotel Circle 10/10 Excellent "." [](https://expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Mission-ValleyHotel-Circle.h1987617.Hotel-Information) ![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Clean" [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "The riom was great, staff was very friendly, lots of things to do in and around the hotel." [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Kings Inn San Diego](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg) ### Kings Inn San Diego 10/10 Excellent "We love the beautiful and comfortable rooms and having meals at the Waffle House. Thr proximity to shopping and all things San Diego is great too. We will return again. " [](https://expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in Mission Valley with Expedia? ### How can I find cheap business-friendly hotels in Mission Valley? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Cheap Hotels in Birdland ](https://www.expedia.ca/Birdland-San-Diego-Hotels-Cheap-Hotels.0-n553248635976479135-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotels-With-Indoor-Pool.0-0-d6068523-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Oceanfront-Hotels.0-0-d6068523-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - 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