Title: Book the Best Mission Valley Adults Only Resorts & Hotels in 2026 from CA $80 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Mission Valley Car Rentals](https://expedia.ca/Car-Rentals-In-Mission-Valley.d800124.Car-Rental-Guide)[Mission Valley Vacations](https://expedia.ca/Mission-Valley.d800124.Destination-Travel-Guides) ![Closeup of the Adobe walls of the historic Mission De Alcala San Diego California](https://images.trvl-media.com/place/800124/80ddc530-f226-4f74-8ff4-45354a1ef339.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Adults Only Resorts & Hotels in Mission Valley, CA from CA $80 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission Valley Adults Only Resorts & Hotels Tonight [Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Tomorrow [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=800124&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) ## Our top choices for Mission Valley adults-only hotels ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/22ecf276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/08cac484.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/250333ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/3bb415c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) El Cajon 9.2/10 Wonderful (1635) "Very peaceful resort " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Camilla [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Memory foam beds, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/dc9bc184.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Books](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/606df34a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/2180fd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/04f95010.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stay Classy Hostel [](https://www.expedia.ca/San-Diego-Hotels-Stay-Classy.h54911318.Hotel-Information) Downtown San Diego 9.6/10 Exceptional (786) "Good place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sai CA $70 CA $80 total includes taxes & fees Jan 13 - Jan 14, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Stay-Classy.h54911318.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01®ionId=800124&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true) ## Top Mission Valley Hotel Reviews ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 10/10 Excellent "Nice room, good ambiance, central location " [](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ## Frequently asked questions ### How can I find cheap adults-only hotels in Mission Valley? ### From what age can you stay in an adult-only hotel in Mission Valley? ### Are all adult-only resorts all-inclusive in Mission Valley? ### Why book your adults-only hotel in Mission Valley with Expedia? ### When is the best time to stay at an adult-only all-inclusive resort in Mission Valley? ### Can I cancel or change my adult-only resort booking? ## Explore a world of travel with Expedia - 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