Title: Book the Best Mira Mesa SPA Resorts from CA $164 - Spa Hotels in Mira Mesa, San Diego | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Mira Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Mira-Mesa.d6191795.Car-Rental-Guide)[Mira Mesa Vacations](https://expedia.ca/Mira-Mesa.d6191795.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Mira Mesa, San Diego from CA $164 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mira Mesa Spa Hotels Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=6191795&startDate=2025-10-13&endDate=2025-10-14&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=6191795&startDate=2025-10-14&endDate=2025-10-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6191795&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6191795&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mira Mesa Spa Hotels ![Fitness studio](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/8d3908bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/91cdc1c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/7910f1d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/8995625e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort El Cajon 9.2/10 Wonderful (1569) "Great resort!" CA $150 CA $182 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/900/858/93b051f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/900/858/c6795882.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse](https://images.trvl-media.com/lodging/1000000/10000/900/858/36c2b78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina San Diego 8.4/10 Very good (1544) "Clean rooms great view amazing pool and we loved the breakfast " CA $237 CA $346 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/8496a8ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/5c2bbbc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/8c14c190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/3af899ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Island Palms Hotel & Marina Point Loma 8.8/10 Excellent (1551) "Great place to go fishing and hang out by the pool and paddle board in the bay. We go here every year. " CA $169 CA $194 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Plus-Island-Palms-Hotel-Marina.h9660.Hotel-Information) ![Body treatments, aromatherapy, body wraps, body scrubs, facials](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/b1fc21d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/ed2e1ba0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/9fc82331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine, ocean views ](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/06f19e3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Bayfront Downtown San Diego 8.6/10 Excellent (1778) "My stay here is excellent and the staff is amazing. " CA $258 CA $368 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/7cb5b7d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/cc6aac5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/98dcc319.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/52554aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Humphreys Half Moon Inn Point Loma 9.2/10 Wonderful (2558) "Perfect stay " CA $189 CA $246 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Humphreys-Half-Moon-Inn.h36183.Hotel-Information) ![Couples treatment rooms, sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/d9cbfe80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/99024d06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/423e7241.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loews Coronado Bay Resort Silver Strand 8.8/10 Excellent (1046) "Beautiful quiet hotel." CA $279 CA $373 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ![Spa](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/25a004df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand, windsurfing, beach volleyball](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c20f7d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c2cecb91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Mission Bay Resort San Diego 8.4/10 Very good (1303) "Very clean resort" CA $279 CA $384 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/5000000/4780000/4772300/4772239/a53ee749.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4780000/4772300/4772239/5650d394.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/5000000/4780000/4772300/4772239/f36d5f00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; beach views](https://images.trvl-media.com/lodging/5000000/4780000/4772300/4772239/89dada8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cape Rey Carlsbad Beach, a Hilton Resort & Spa South Beach 8.6/10 Excellent (1010) "Great location and loved the restaurant the most." CA $194 CA $274 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Carlsbad-Hotels-Cape-Rey-Carlsbad-Beach.h4772239.Hotel-Information) ![Premier Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/fde0003f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/6257cb78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/76794add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/cc4883a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Handlery Hotel Mission Valley 8.2/10 Very good (2128) "Very nice stay" CA $143 CA $164 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/8bb8fc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/91baa1e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/a5cb77af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Marina Gateway Hotel National City 9.2/10 Wonderful (3328) "Nice place to stay !" CA $188 CA $207 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-27&endDate=2025-10-28®ionId=6191795&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Mira Mesa ### Top Mira Mesa attractions for a relaxing vacation Mira Mesa boasts several activities for travellers seeking spa hotels, each offering a unique blend of relaxation and adventure. Begin your day at the stunning Miramar Reservoir, where you can enjoy serene walking trails, picnicking spots, and picturesque views, perfect for unwinding before indulging in spa treatments. For a touch of culture, visit the nearby San Diego Museum of Art, which offers rotating exhibitions and an impressive permanent collection, allowing you to immerse yourself in creativity and inspiration. If you're in the mood for nature, head to the lush expanses of the Los Penasquitos Canyon Preserve, where you can hike scenic trails and discover hidden waterfalls, providing a refreshing escape in between spa visits. Kids will love the interactive exhibits at the nearby Kid Ventures, ensuring that they have their own slice of fun while you enjoy some well-deserved pampering. Finally, wrap up your day with a visit to a local restaurant like The Fish Market, where you can savour fresh seafood with stunning views of the water, perfect for a family meal after a day of relaxation. Staying in hotels with spas in Mira Mesa means you can easily access these attractions while enjoying luxurious amenities. Imagine unwinding in a sumptuous spa suite after a day filled with exploration, with treatments designed to rejuvenate your body and mind, and attentive staff ready to cater to your needs. The combination of local charm and exceptional service makes for a truly memorable experience. ## Top Mira Mesa Hotel Reviews ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "The hotel is clean and relaxing. The staff is courteous and always eager to accommodate. The best part was the coffee machine in the lobby. I'll be returning. " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Great that there is an airport shuttle. Very convenient to cruise terminal." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](//images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Location, price amazing! Friendly staff" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Amazing property " [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![DoubleTree by Hilton San Diego - Del Mar](//images.trvl-media.com/lodging/1000000/20000/15300/15236/5afe6cec_y.jpg) ### DoubleTree by Hilton San Diego - Del Mar 10/10 Excellent "Nice staff.! " [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Very clean, easy to move a lot things to do and Tourist Really love it" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Great location for the gaslamp" [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![The Little Italy Hotel Downtown San Diego](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### The Little Italy Hotel Downtown San Diego 10/10 Excellent "Clean room clean bathroom staff was friendly. Wi-Fi worked easily. I would definitely book again." [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Manchester Grand Hyatt San Diego](//images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4_y.jpg) ### Manchester Grand Hyatt San Diego 10/10 Excellent "The staff was very helpful and accommodating whenever I needed something they were able to help me right away and had a quick response if I needed to have anything delivered to the room or any other questions I had" [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Mira Mesa? > Forget the stress of everyday life and book yourself a hotel with a spa. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away. ### What's there to see and do in Mira Mesa? > Enjoy Mira Mesa and visit Mission Bay, San Diego Zoo, and Mission Beach. If you have spare time during your trip, you might want to make a stop at Marine Corps Recruit Depot and Port of San Diego. ### What is a Mira Mesa spa hotel? > Spa hotels in Mira Mesa provide lodging and have an on-site spa offering services like couples massages as well as body treatments. Some also offer in-room treatments. 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