Title: Book the Best Mexico LUXURY Hotels - Upscale Hotels in Mexico, MO | Expedia.ca [Mexico Travel Guide](https://expedia.ca/Mexico.dx8832)[Hotels in Mexico](https://expedia.ca/Mexico-Hotels.d8832.Travel-Guide-Hotels)[Vacation Rentals in Mexico](https://expedia.ca/Mexico-Vacation-Rentals.d8832.Travel-Guide-VacationRentals)[Flights to Mexico](https://expedia.ca/Cheap-Flights-To-Mexico.d8832.Travel-Guide-Flights)[Mexico Car Rentals](https://expedia.ca/Car-Rentals-In-Mexico.d8832.Car-Rental-Guide)[Mexico Vacation Packages](https://expedia.ca/Mexico.d8832.Destination-Travel-Guides) ![An old historic schoolhouse in Mexico, Missouri](https://images.trvl-media.com/place/8832/e1361911-161d-4582-a125-73ebc2a9a18c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Mexico, MO - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mexico Luxury Hotels Tonight [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=8832&startDate=2025-12-14&endDate=2025-12-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=8832&startDate=2025-12-15&endDate=2025-12-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=8832&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=8832&startDate=2025-12-26&endDate=2025-12-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Mexico luxury hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/151300/151247/d033dcd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking (Mobility Accessible)](https://images.trvl-media.com/lodging/1000000/160000/151300/151247/9d779a86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/160000/151300/151247/fcdb510e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free toiletries, towels](https://images.trvl-media.com/lodging/1000000/160000/151300/151247/24e32f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Mexico [](https://www.expedia.ca/Columbia-Hotels-Days-Inn-By-Wyndham-Mexico.h151247.Hotel-Information) Mexico 7.0/10 Good (296) "Comfortable bed... Didn't like stool loose on base." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marvin CA $105 CA $118 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Columbia-Hotels-Days-Inn-By-Wyndham-Mexico.h151247.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-28&endDate=2025-12-29®ionId=8832&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Mexico ### Mexicoand its attractions for luxury travelers In the charming town of Mexico, Missouri, luxury travellers can indulge in a variety of enriching experiences. Start your journey at the beautiful Audrain County Historical Society, where you can explore fascinating exhibits that showcase the region's rich heritage, all while enjoying a serene atmosphere. Nature enthusiasts will appreciate the stunning views at the nearby Mark Twain State Park, perfect for leisurely hikes and picnics amidst the picturesque landscapes. For a touch of elegance, treat yourself to a fine dining experience at one of the local upscale restaurants, where you can savour exquisite dishes crafted from fresh, local ingredients. If you're a golf aficionado, the Mexico Country Club offers a beautifully manicured course with stunning views, providing an excellent opportunity to unwind. After a day of exploration, consider staying at a luxurious hotel in the downtown area, where you can enjoy modern amenities and attentive service, ensuring a restful retreat. The combination of rich cultural experiences and comfortable accommodations makes Mexico, Missouri a hidden gem for the discerning traveller. ## Top Mexico Hotel Reviews ![Super 8 by Wyndham Columbia East](https://images.trvl-media.com/lodging/2000000/1050000/1044300/1044261/f8795c2e_y.jpg) ### Super 8 by Wyndham Columbia East 10/10 Excellent "It was clean room." [](https://expedia.ca/Columbia-Hotels-Super-8-By-Wyndham-Columbia-East.h1044261.Hotel-Information) ![Best Western Plus Columbia Inn](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/2c317c73_y.jpg) ### Best Western Plus Columbia Inn 10/10 Excellent "Everything was very good." [](https://expedia.ca/Columbia-Hotels-Best-Western-Plus-Columbia-Inn.h12546284.Hotel-Information) ![Quality Inn & Suites Columbia I-70](https://images.trvl-media.com/lodging/1000000/20000/14600/14520/41147965_y.jpg) ### Quality Inn & Suites Columbia I-70 10/10 Excellent "Clean rooms and excellent service" [](https://expedia.ca/Columbia-Hotels-Quality-Inn-Suites-Columbia-I-70.h14520.Hotel-Information) ![Hampton Inn & Suites Columbia at University](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009513/2702d693_y.jpg) ### Hampton Inn & Suites Columbia at University 10/10 Excellent "The hotel room, staff and all were excellent" [](https://expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-Columbia-At-University.h2009513.Hotel-Information) ![Ramada by Wyndham Columbia](https://images.trvl-media.com/lodging/1000000/20000/18900/18803/77d8da33_y.jpg) ### Ramada by Wyndham Columbia 10/10 Excellent "Room was very clean and staff was attentive. " [](https://expedia.ca/Columbia-Hotels-Ramada-By-Wyndham-Columbia.h18803.Hotel-Information) ![Red Roof Inn Columbia, MO](https://images.trvl-media.com/lodging/1000000/20000/19600/19600/63579173_y.jpg) ### Red Roof Inn Columbia, MO 10/10 Excellent "Friendly staff" [](https://expedia.ca/Columbia-Hotels-Red-Roof-Inn-Columbia.h19600.Hotel-Information) ![Days Inn by Wyndham Mexico](https://images.trvl-media.com/lodging/1000000/160000/151300/151247/d033dcd0_y.jpg) ### Days Inn by Wyndham Mexico 10/10 Excellent "Comfortable bed... Didn't like stool loose on base." [](https://expedia.ca/Columbia-Hotels-Days-Inn-By-Wyndham-Mexico.h151247.Hotel-Information) ## Frequently asked questions ### Which area of Mexico is best to stay in for luxury hotels? > This area is the heart of Mexico, Missouri, offering the most upscale accommodation options. It's well-connected and provides easy access to the town's amenities. You'll find the highest concentration of quality hotels here, often featuring amenities like high-end fitness equipment, indoor pools, and spacious rooms. > > > Couples looking for a comfortable and convenient stay will find this area ideal. It's close to local dining options and provides a good base for exploring the town, such as visiting the Audrain County Historical Society or enjoying a stroll in the nearby parks. ### How much does a luxury hotel in Mexico cost? ### What luxury activities and experiences are there in Mexico? > This area offers a good balance of convenience and access to local amenities. You'll find a selection of local eateries, a few shops, and the city's historical sites within easy reach. The layout is quite straightforward, making it simple to navigate on foot or by car. > > > For couples looking for a relaxed getaway, staying near the town centre provides easy access to the local parks and the historic sites. You can enjoy a leisurely stroll through the city or visit the Audrain County Historical Society. > > > Solo travellers will also find the town centre convenient. ### How can I save on a luxury hotel in Mexico with Expedia? ### Is it cheaper to book a luxury Mexico hotel and flights as a package? ### Can I cancel my luxury hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Clark ](https://www.expedia.ca/5Star-Clark-Hotels.s50-0-d553248634983448940.Travel-Guide-Filter-Hotels) - [Auxvasse Hotels ](https://www.expedia.ca/Auxvasse-Hotels.d3000349276.Travel-Guide-Hotels) - [Condo Rentals in Centralia ](https://www.expedia.ca/Centralia-Condos.d553248634983532232-aaCondos.Travel-Guide-Accommodation) - [Luxury Hotels in Centralia ](https://www.expedia.ca/Centralia-Hotels-Luxury-Hotel.0-0-d553248634983532232-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Centralia Hotels ](https://www.expedia.ca/Centralia-Hotels.d553248634983532232.Travel-Guide-Hotels) - 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