Title: Book the Best Mesilla LUXURY Hotels - Upscale Hotels in Mesilla, NM | Expedia.ca [Hotels in Mesilla](https://expedia.ca/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Vacation Rentals in Mesilla](https://expedia.ca/Mesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals)[Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.ca/Mesilla.d132684.Destination-Travel-Guides) ![Red chile doorway Mesilla NM](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Mesilla, NM - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesilla Luxury Hotels Tonight [Nov 23 - Nov 24](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-23&endDate=2025-11-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 24 - Nov 25](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-24&endDate=2025-11-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-28&endDate=2025-11-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Mesilla Luxury Hotels ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=AFFINITY_BF_PROMO_132684) ## Top Mesilla Hotel Reviews ![Days Inn by Wyndham Las Cruces](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df_y.jpg) ### Days Inn by Wyndham Las Cruces 10/10 Excellent "Good breakfast. I especially liked the fresh waffles. The orange juice was delicious! Parking was plentiful and close to the room, and well lit. The room was comfortable and clean. The staff was friendly and helpful." [](https://expedia.ca/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![Hotel Encanto de Las Cruces](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 10/10 Excellent "Room was very very nice. Loved the hot tub. Staff was very friendly. The hotel was very ellegant with the hacienda mexican vibe and i loved it. Definitely going to go back." [](https://expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45_y.jpg) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain 10/10 Excellent "Clean,large room with refrigerator and microwave." [](https://expedia.ca/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Drury Inn & Suites Las Cruces](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/0bffe062_y.jpg) ### Drury Inn & Suites Las Cruces 10/10 Excellent "Great staff, super clean, great rooms and amenities! Would definitely stay here again if ever in the area!" [](https://expedia.ca/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![Springhill Suites By Marriott Las Cruces](https://images.trvl-media.com/lodging/1000000/210000/203700/203622/ee15ba4f_y.jpg) ### Springhill Suites By Marriott Las Cruces 10/10 Excellent "Yes,yes" [](https://expedia.ca/Las-Cruces-Hotels-Springhill-Suites-By-Marriott-Las-Cruces.h203622.Hotel-Information) ![Hilton Garden Inn Las Cruces](https://images.trvl-media.com/lodging/3000000/2880000/2870400/2870330/a3f63928_y.jpg) ### Hilton Garden Inn Las Cruces 10/10 Excellent "Nice" [](https://expedia.ca/Las-Cruces-Hotels-Hilton-Garden-Inn-Las-Cruces.h2870330.Hotel-Information) ![Quality Inn & Suites Las Cruces - University Area](https://images.trvl-media.com/lodging/1000000/50000/43200/43177/d64502c0_y.jpg) ### Quality Inn & Suites Las Cruces - University Area 10/10 Excellent "Great place to stay " [](https://expedia.ca/Las-Cruces-Hotels-Quality-Inn-Suites-Las-Cruces-University-Area.h43177.Hotel-Information) ![La Quinta Inn by Wyndham Las Cruces Mesilla Valley](https://images.trvl-media.com/lodging/1000000/20000/15400/15369/c71afdd0_y.jpg) ### La Quinta Inn by Wyndham Las Cruces Mesilla Valley 8/10 Good "Doing renovations so kewp in mind. But only had 1 pot of coffee for everyone and seemed bothered when asked of they could make more. " [](https://expedia.ca/Las-Cruces-Hotels-La-Quinta-Inn-By-Wyndham-Las-Cruces-Mesilla-Valley.h15369.Hotel-Information) ![Comfort Suites University Las Cruces](https://images.trvl-media.com/lodging/1000000/50000/43200/43179/3f986bbe_y.jpg) ### Comfort Suites University Las Cruces 10/10 Excellent "Clean room and very helpful staff " [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Suites-University-Las-Cruces.h43179.Hotel-Information) ## Frequently asked questions ### Which area of Mesilla is best to stay in for luxury hotels? > The best area to stay in Mesilla for luxury hotels is around the Historic Old Mesilla Plaza. > > > > This central area is the heart of Mesilla, a short walk from the plaza itself, which is a National Historic Landmark. You'll find a selection of high-end hotels and inns here, many of which are housed in historic buildings, offering a blend of traditional New Mexican architecture and modern comforts. The plaza is surrounded by shops selling local crafts, art galleries, and restaurants serving regional cuisine. > > > > Couples looking for a romantic getaway will particularly enjoy staying near the Historic Old Mesilla Plaza. The area offers a tranquil setting with beautiful adobe buildings and courtyards, superb for evening strolls. ### How much does a luxury hotel in Mesilla cost? > Luxury hotel prices in Mesilla vary, but you can find a great deal on Expedia. To find the best prices on luxury stays, be flexible with your dates—typically, off-peak and mid-week stays are cheaper. Sort your search results by "Price: low to high" to see our lowest rates. ### What luxury activities and experiences are there in Mesilla? > The best area to stay in Mesilla for luxury activities and experiences is within the historic Old Mesilla Plaza and its immediate surroundings. > > > > This central area is the heart of Mesilla, known for its adobe architecture, art galleries, and upscale dining. The Plaza itself is a historic landmark, surrounded by shops selling local crafts and art. You'll find many of the premium experiences within a short walk of this central square. > > > > For couples looking for a refined experience, the area around the Plaza offers excellent opportunities. You can enjoy gourmet dining at restaurants featuring regional cuisine, often with outdoor seating in pleasant courtyards. Many of the local art galleries showcase high-calibre works, superb for an afternoon browse. You might also find boutique accommodations that offer a more intimate and personalised stay, some with amenities like private patios or bespoke culinary offerings. > > > > Travellers seeking unique, premium experiences will appreciate the bespoke shopping found in the boutiques around the Plaza. These shops often feature handcrafted jewellery, custom art pieces, and artisan goods that reflect the rich cultural heritage of the region. ### How can I save on a luxury hotel in Mesilla with Expedia? > There are plenty of ways to save on a luxury hotel in Mesilla. Unlock our lowest prices by joining [One Key™](https://www.expedia.ca/welcome-one-key), Expedia's travel rewards program. It's free and easy to sign up, and you can access member perks too. Typically, booking in advance will help you save on your luxury hotel booking. If you're feeling spontaneous, be sure to check for last-minute deals. ### Is it cheaper to book a luxury Mesilla hotel and flights as a package? > Booking a hotel and flight package on Expedia can be cheaper than booking flights and hotels separately. Bundling can lead to significant savings, especially for international travel or when booking well in advance. However, savings vary depending on factors like destination, travel dates, and availability, so it's wise to compare options. With access to over 300,000 hotels worldwide, Expedia makes it easy to build the perfect [travel package](https://www.expedia.ca/Mesilla.d132684.Destination-Travel-Guides). ### Can I cancel my luxury hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline. This is often within 24-48 hours of your scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. 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