Title: Hotels by Independent in Medical District from CA $345 | Expedia.ca [Medical District Travel Guide](https://expedia.ca/Greenville-Medical-District.dx908649044914896896)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d2779.Travel-Guide-VacationRentals)[Flights to Greenville](https://expedia.ca/Cheap-Flights-To-Greenville.d2779.Travel-Guide-Flights)[Things to do in Greenville](https://expedia.ca/Things-To-Do-In-Greenville.d2779.Travel-Guide-Activities)[Medical District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-District.d908649044914896896.Car-Rental-Guide)[Medical District Vacations](https://expedia.ca/Medical-District.d908649044914896896.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Medical District from CA $345 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical District Independent Hotels ![Standard Suite, 1 Queen Bed | Private kitchen](https://images.trvl-media.com/lodging/3000000/2690000/2682700/2682635/41b082ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, 1 King Bed | Living area](https://images.trvl-media.com/lodging/3000000/2690000/2682700/2682635/2d2ef9ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2690000/2682700/2682635/73b5df1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 Queen Bed | Private kitchen](https://images.trvl-media.com/lodging/3000000/2690000/2682700/2682635/5316c438.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Affordable Suites Greenville Greenville 8.4/10 Very good (560) "My room was great and spacious and the water had great heat I also really appreciated how great the staff were " [](https://www.expedia.ca/Greenville-Hotels-Affordable-Suites.h2682635.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/99000000/98410000/98403900/98403868/a05fe940.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/99000000/98410000/98403900/98403868/a74dbd7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, Smoking](https://images.trvl-media.com/lodging/99000000/98410000/98403900/98403868/01e3a5fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/99000000/98410000/98403900/98403868/f067097d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Economy Inn of Greenville, NC Greenville 4.6/10 (70) "Omg. The only time I’ve ever seen a place this bad was on a movie where drug addicts and roaches live. " [](https://www.expedia.ca/Greenville-Hotels-1901-Stantonsburg-Rd.h98403868.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/425400/425334/cc452de1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, freezer](https://images.trvl-media.com/lodging/1000000/430000/425400/425334/a2abcd66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/430000/425400/425334/a86802f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/425400/425334/05a650cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### InTown Suites Extended Stay Greenville Greenville 6.4/10 (492) "I booked there a week in advance,but when i got there,they told mw that there ia no room available for me.book somewhere else." [](https://www.expedia.ca/Greenville-Hotels-InTown-Suites-Extended-Stay-Greenville.h425334.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/79000000/78310000/78302400/78302378/e07cc20d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/79000000/78310000/78302400/78302378/w3528h2355x0y0-448dc713.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/79000000/78310000/78302400/78302378/ba2642ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/79000000/78310000/78302400/78302378/d68dffa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Bungalow 2 Blocks from Uptown Action & 6 Blocks from ECU! Greenville 9.8/10 Exceptional (44) "Great walking location to downtown. " [](https://www.expedia.ca/Greenville-Hotels-Historic-Bungalow-2-Blocks-From-Uptown-Action-6-Blocks-From-ECU.h78302378.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106930000/106929800/106929755/1cbdf57c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/107000000/106930000/106929800/106929755/e79ddf92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/107000000/106930000/106929800/106929755/755d0560.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106930000/106929800/106929755/3846067d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy 1-bedroom apartment in Ayden located in our home with its own entrance. Ayden 10/10 Exceptional (13) "Great experience and stay! " [](https://www.expedia.ca/Ayden-Hotels-Cozy-1-Bedroom-Apartment-In-Ayden-Located-In-Our-Home-With-Its-Own-Entrance.h106929755.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/114000000/113670000/113666400/113666349/cf13146a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113670000/113666400/113666349/9a8a3ce9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/114000000/113670000/113666400/113666349/eb10fd64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/114000000/113670000/113666400/113666349/2855ab3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 3-bedroom 2.5-bathroom townhome with WiFi and AC in Greenville Greenville 8.4/10 Very good (6) "What an amazing home! Had a splendid experience we got to enjoy the dining room, kitchen and having a bedroom for each one of us was amazing got a lot of rest but most importantly had a great trip. I would forjare book this rental next time I’m in town " CA $280 CA $499 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Greenville-Hotels-Charming-3-Bedroom-25-Bathroom-Townhome-With-WiFi-And-AC-In-Greenville.h113666349.Hotel-Information) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/117000000/116860000/116853800/116853756/37957f29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/117000000/116860000/116853800/116853756/5e4e8c76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116860000/116853800/116853756/936263c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/117000000/116860000/116853800/116853756/1ba352c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 2-bedroom condo in Greenville near ECU and ECU Health Greenville 10/10 Exceptional (3) "Great location and very cool apartment!" CA $119 CA $345 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Greenville-Hotels-Charming-2-Bedroom-Condo-In-Greenville-Near-ECU-And-ECU-Health.h116853756.Hotel-Information) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/101000000/100900000/100891800/100891787/bd923521.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100900000/100891800/100891787/f8de0fef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/101000000/100900000/100891800/100891787/472ca575.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/101000000/100900000/100891800/100891787/c3900978.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ECU Pirate Country Getaway! First-floor Master, extra room, and separate office! Greenville 10/10 Exceptional (15) "The property was very clean and well appointed. Location was perfect for what we needed!" CA $176 CA $404 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Greenville-Hotels-ECU-Pirate-Country-Retreat-Master-On-1st-Floor.h100891787.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/113000000/112940000/112932800/112932701/73cd33ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/113000000/112940000/112932800/112932701/8fcd9d79_edited_1014.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112940000/112932800/112932701/e41027e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112940000/112932800/112932701/41538025.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vintage2 Chestnut Duplex Greenville 10/10 Exceptional (3) "Very clean on a quiet street and just close enough to ECU campus. " [](https://www.expedia.ca/Greenville-Hotels-Vintage2-Chestnut-Duplex.h112932701.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/55000000/54140000/54135900/54135838/fb3b3984.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/55000000/54140000/54135900/54135838/a604103a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/55000000/54140000/54135900/54135838/3271fb9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/55000000/54140000/54135900/54135838/057b0b1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Greenville Classic House Greenville 9.8/10 Exceptional (44) "My family and I absolutely loved our stay at the Greenville Classic house. The house was clean and met all of our needs." [](https://www.expedia.ca/Greenville-Hotels-Vrbo-Property.h54135838.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-26&endDate=2025-10-27®ionId=908649044914896896&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMedical-District-Greenville-Hotels-Independent.0-n908649044914896896-0--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMedical-District-Greenville-Hotels-Independent.0-n908649044914896896-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Medical District Hotel Reviews ![Hilton Greenville](//images.trvl-media.com/lodging/1000000/10000/1600/1575/39cdf1d9_y.jpg) ### Hilton Greenville 10/10 Excellent "Hotel was very nice and clean. " [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h1575.Hotel-Information) ![Homewood Suites By Hilton Greenville, NC](//images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/36cd8e9e_y.jpg) ### Homewood Suites By Hilton Greenville, NC 10/10 Excellent "Very clean property , good breakfast and very polite and helpful front desk " [](https://expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville.h90153266.Hotel-Information) ![Staybridge Suites Greenville Medical Center by IHG](//images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/356f6fc4_y.jpg) ### Staybridge Suites Greenville Medical Center by IHG 10/10 Excellent "Always a great stay" [](https://expedia.ca/Greenville-Hotels-Staybridge-Suites-Greenville-Medical-Center.h104466390.Hotel-Information) ![Best Western Plus Suites-Greenville](//images.trvl-media.com/lodging/1000000/300000/296600/296584/d19b7bd8_y.jpg) ### Best Western Plus Suites-Greenville 10/10 Excellent "Rooms clean bed comfy" [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Suites-Greenville.h296584.Hotel-Information) ![Fairfield Inn & Suites by Marriott Greenville](//images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/03136946_y.jpg) ### Fairfield Inn & Suites by Marriott Greenville 10/10 Excellent "Location & Clean" [](https://expedia.ca/Greenville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville.h20392562.Hotel-Information) ![Microtel Inn & Suites by Wyndham Greenville/University Medic](//images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/2e252281_y.jpg) ### Microtel Inn & Suites by Wyndham Greenville/University Medic 10/10 Excellent "Everything was well prepared and clean. Me and my girlfriend appreciate the black lady at the desk for being so polite with us as we had some issues before arrriving." [](https://expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-GreenvilleUniversity-Medic.h2009531.Hotel-Information) ![Hampton Inn Washington](//images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742_y.jpg) ### Hampton Inn Washington 10/10 Excellent "Pool not working. Breakfast was ok" [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Comfort Inn & Suites Greenville Near Convention Center](//images.trvl-media.com/lodging/1000000/220000/217400/217352/2d5a6141_y.jpg) ### Comfort Inn & Suites Greenville Near Convention Center 10/10 Excellent "Nice staff and convenient location perfect for short term. " [](https://expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville.h217352.Hotel-Information) ![Holiday Inn Express Greenville by IHG](//images.trvl-media.com/lodging/1000000/110000/102500/102482/30d4a3d9_y.jpg) ### Holiday Inn Express Greenville by IHG 10/10 Excellent "Staff was friendly!" [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Express-Greenville.h102482.Hotel-Information) ## Find out more about Medical District ## Medical District Hotels Guide Expedia.ca offers a selection of 160 hotels in Medical District. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Medical District. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Medical District neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Medical District, Greenville now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Patton Hospitality Management Hotels in Atlantic Beach](https://www.expedia.ca/Atlantic-Beach-Hotels-Patton-Hospitality-Management.0-0-d10857--bPattonHospitalityManagement.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Ayden](https://www.expedia.ca/Ayden-Hotels-Cheap-Hotels.0-0-d3000422385-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Ayden](https://www.expedia.ca/Ayden-Hotels-Luxury-Hotel.0-0-d3000422385-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Ayden Hotels](https://www.expedia.ca/Ayden-Hotels.d3000422385.Travel-Guide-Hotels) - [Hilton Hotels in Bahama](https://www.expedia.ca/Bahama-Hotels-Hilton-Hotels.0-0-d6320162--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Benson](https://www.expedia.ca/Benson-Hotels-Marriott-Hotels-Resorts.0-0-d6742--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - 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