Title: Book the Best HISTORIC Hotels in Medical District in 2025 | Expedia.ca [Medical District Travel Guide](https://expedia.ca/Greenville-Medical-District.dx908649044914896896)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d2779.Travel-Guide-VacationRentals)[Flights to Greenville](https://expedia.ca/Cheap-Flights-To-Greenville.d2779.Travel-Guide-Flights)[Medical District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-District.d908649044914896896.Car-Rental-Guide)[Medical District Vacations](https://expedia.ca/Medical-District.d908649044914896896.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/historic.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Historic Hotels in Medical District, NC from CA $103 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical District Historic Hotels Tonight [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical District Historic Hotels We don't have any properties that match your exact search [See all properties in Medical District](https://expedia.ca/Hotel-Search?startDate=2025-11-06&endDate=2025-11-07®ionId=908649044914896896&adults=2) ## Recommended hotels in Medical District ![Reception](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/1f6092e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/b26d4f63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/2deb739b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/2203e988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard Marriott Greenville Medical District 8.8/10 Excellent (874) "It was easy to access. Staff was friendly and accomodating. Room was clean and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy CA $178 CA $201 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Greenville-Hotels-Courtyard-Marriott-Greenville.h119042.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/356f6fc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/2692ddf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/fdf12260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/ce0cefde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Greenville Medical Center by IHG Greenville 9.4/10 Exceptional (169) "Always a great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $140 CA $158 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Staybridge-Suites-Greenville-Medical-Center.h104466390.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/5f6c9580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/f018a95f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/504a2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/7b52f8d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn and Suites by Marriott Washington Washington 9.4/10 Exceptional (613) "The check in was quick, the room was clean, and the breakfast option was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Johnia CA $165 CA $186 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Greenville-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Washington.h18068553.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/36cd8e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/12a39e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/951ab926.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![42-inch Smart TV with cable channels, TV](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/4540394d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites By Hilton Greenville, NC Greenville 9.4/10 Exceptional (282) "Very clean property , good breakfast and very polite and helpful front desk " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ranganath CA $160 CA $181 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville.h90153266.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queen beds non smoking](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/9c141e18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/ea4d109f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/2472bd66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Washington Washington 8.2/10 Very good (644) "Breakfast was very good, staff friendly. Enjoyable stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $154 CA $164 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2557x3y3-9ca87b37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2560x3y0-dfdc5921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3840h2556x0y4-0c33f88e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3840h2557x0y3-6eee03ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden INN Greenville University Uptown Greenville 9.4/10 Exceptional (83) "Excellent stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $178 CA $201 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Hilton-Garden-INN-Greenville-University.h108395066.Hotel-Information) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/d19b7bd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/feceae8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Jetted Tub (Oversized Room;with Sofabed)](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/9f657c06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/f93c58cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Suites-Greenville Greenville 9.0/10 Wonderful (1001) "Nice suites Beautiful hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ulysses CA $152 CA $172 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Suites-Greenville.h296584.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/5ca75dae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, pillowtop beds, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/92dee2af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/0acd51fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/2a68663a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Greenville near East Carolina University Greenville 8.6/10 Excellent (374) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Justine CA $150 CA $169 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville.h217352.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/30d4a3d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, cribs/infant beds](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/c98c2c60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/faaccec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/fdb16233.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Greenville by IHG Greenville 8.4/10 Very good (952) "We will definitely stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather Beachum CA $133 CA $150 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Holiday-Inn-Express-Greenville.h102482.Hotel-Information) ![In-room safe, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/2e252281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/bebdabe1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/16e45970.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/4f9896f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Greenville/University Medic Greenville 7.2/10 Good (1002) "I always book here! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Briana CA $92 CA $103 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-GreenvilleUniversity-Medic.h2009531.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-06&endDate=2025-11-07®ionId=908649044914896896&adults=2&specialized_stays_group_explore=historic_property&sort=RECOMMENDED&openPlayBack=true) ## Top Medical District Hotel Reviews ![Hampton Inn Washington](//images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742_y.jpg) ### Hampton Inn Washington 10/10 Excellent "Breakfast was very good, staff friendly. Enjoyable stay." [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Holiday Inn Greenville by IHG](//images.trvl-media.com/lodging/1000000/20000/12900/12870/8d14df71_y.jpg) ### Holiday Inn Greenville by IHG 10/10 Excellent "Property was nice and well kept. Breakfast was good though not a lot of choice." [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Greenville.h12870.Hotel-Information) ## Frequently asked questions ### What should a history buff expect from a stay in Medical District? > Significant historical sites in Medical District are likely at the top of your travel itinerary. And take some time to discover the other places of interest while you're in the area. ### How many historical hotels are located in Medical District? > There are 128 hotel accommodations bookable on Expedia in the larger area of Greenville, though you won't find many designated historic hotels. ### What are the most important historical sites and other places in Medical District? > A favorite place to visit is Laupus Health Sciences Library. You'll also find Arlington Crossing and Williams Arena at Minges Coliseum in the area. ### What is a historic hotel like in Medical District? > Guests who book a historic hotel can spend a night or two someplace that has an officially recognized national historic designation. A castle, a palace or even a pub or an old police station can be turned into a historic hotel as long as it has special significance. Traditional architecture and period features are often found in the guestrooms or communal spaces of these historic hotels in Medical District, giving a sense of history. ### What is the difference between a historic hotel and a heritage hotel? > "Heritage hotel" is a term often used in Asia and Europe, while "historic hotel" is a term often used in the U.S. though overall the terms are quite similar. The architecture and actual building of a historic hotel is generally what's most important. For a heritage hotel, often it's the cultural value as well as how it shaped the community. ### Do historic hotels in Medical District have modern facilities? > Hotels include modern conveniences and safety features you've come to expect, but every effort is made to preserve historic facades and treasured traditions. Smart TVs, WiFi, updated bathroom facilities, and the popular amenities found in any hotel should be available at a historic hotel. 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