Title: Book the Best HISTORIC Hotels in Medical District in 2025 | Expedia.ca [Medical District Travel Guide](https://expedia.ca/Greenville-Medical-District.dx908649044914896896)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d2779.Travel-Guide-VacationRentals)[Flights to Greenville](https://expedia.ca/Cheap-Flights-To-Greenville.d2779.Travel-Guide-Flights)[Medical District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-District.d908649044914896896.Car-Rental-Guide)[Medical District Vacations](https://expedia.ca/Medical-District.d908649044914896896.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/historic.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Historic Hotels in Medical District, NC from CA $93 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical District Historic Hotels Tonight [Oct 5 - Oct 6](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-05&endDate=2025-10-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-06&endDate=2025-10-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical District Historic Hotels We don't have any properties that match your exact search [See all properties in Medical District](https://expedia.ca/Hotel-Search?startDate=2025-10-19&endDate=2025-10-20®ionId=908649044914896896&adults=2) ## Recommended hotels in Medical District ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/d19b7bd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/f93c58cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/8fc50c3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/feceae8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Suites-Greenville Greenville 9.0/10 Wonderful (1003) "Nice suites Beautiful hotel" CA $152 CA $171 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Suites-Greenville.h296584.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/36cd8e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/12a39e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/90561384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/951ab926.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites By Hilton Greenville, NC Greenville 9.4/10 Exceptional (278) "I loved it very nice and I will stay again nice and quiet rooms and very clean!" CA $166 CA $188 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville.h90153266.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/356f6fc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/ce0cefde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/fdf12260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/1ffe3d21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Greenville Medical Center by IHG Greenville 9.2/10 Wonderful (140) "Great hotel to stay at" CA $133 CA $150 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Staybridge-Suites-Greenville-Medical-Center.h104466390.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/1f6092e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/2deb739b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/2203e988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/99c73073.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard Marriott Greenville Medical District 8.8/10 Excellent (871) "It was easy to access. Staff was friendly and accomodating. Room was clean and comfortable " CA $183 CA $207 total includes taxes & fees Oct 17 - Oct 18 [](https://www.expedia.ca/Greenville-Hotels-Courtyard-Marriott-Greenville.h119042.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queen beds non smoking](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/9c141e18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/1c40a9e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/2472bd66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Washington Washington 8.2/10 Very good (633) "Great facility. Best in Washington " CA $153 CA $164 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/5f6c9580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/504a2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/f018a95f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/7b52f8d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn and Suites by Marriott Washington Washington 9.4/10 Exceptional (612) "Nice Hotel! " CA $165 CA $186 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Greenville-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Washington.h18068553.Hotel-Information) ![1 bedroom, free WiFi](https://images.trvl-media.com/lodging/75000000/74190000/74186200/74186101/aeb60023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/75000000/74190000/74186200/74186101/8f675560.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/75000000/74190000/74186200/74186101/042c20a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/75000000/74190000/74186200/74186101/7e94c64d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quiet Getaway in Beautiful North Carolina!! Grifton 10/10 Exceptional (5) "Nice spot" CA $112 CA $205 total includes taxes & fees Oct 6 - Oct 7 [](https://www.expedia.ca/Grifton-Hotels-Quiet-Getaway-In-Beautiful-North-Carolina.h74186101.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/67000000/66060000/66051500/66051499/8d31c4e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible](https://images.trvl-media.com/lodging/67000000/66060000/66051500/66051499/ab9c8707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/67000000/66060000/66051500/66051499/7c4c1e94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/67000000/66060000/66051500/66051499/06207e76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cypress Inn & Suites Washington by OYO Chocowinity 4.4/10 (120) "I had booked and paid for the room and didn't stay" CA $78 CA $93 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Greenville-Hotels-Cypress-Inn-Suites.h66051499.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2557x3y3-9ca87b37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2415x3y3-72322295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2560x3y0-dfdc5921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3840h2556x0y4-0c33f88e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden INN Greenville University Uptown Greenville 9.4/10 Exceptional (74) "Rhe hotel was extremely clean and nice. I will definitely stay again." CA $189 CA $213 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Greenville-Hotels-Hilton-Garden-INN-Greenville-University.h108395066.Hotel-Information) ![Suite, 1 Bedroom, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/d55c4c6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/5a87c84b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/15ae8005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/9dd3e245.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Greenville, NC Winterville 7.6/10 Good (793) "Had a good stay here " CA $129 CA $148 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Country-Inn-Suites-By-Radisson.h62311.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-19&endDate=2025-10-20®ionId=908649044914896896&adults=2&specialized_stays_group_explore=historic_property&sort=RECOMMENDED&openPlayBack=true) ## Top Medical District Hotel Reviews ![Hampton Inn Washington](//images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742_y.jpg) ### Hampton Inn Washington 10/10 Excellent "Great facility. Best in Washington " [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Holiday Inn Greenville by IHG](//images.trvl-media.com/lodging/1000000/20000/12900/12870/8d14df71_y.jpg) ### Holiday Inn Greenville by IHG 10/10 Excellent "Property was nice and well kept. Breakfast was good though not a lot of choice." [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Greenville.h12870.Hotel-Information) ## Frequently asked questions ### What should a history buff expect from a stay in Medical District? > Significant historical sites in Medical District are likely at the top of your travel itinerary. And take some time to discover the other places of interest while you're in the area. ### How many historical hotels are located in Medical District? > There are 129 hotel accommodations bookable on Expedia in the larger area of Greenville, though you won't find many designated historic hotels. ### What are the most important historical sites and other places in Medical District? > A favorite place to visit is Laupus Health Sciences Library. You'll also find Arlington Crossing and Williams Arena at Minges Coliseum in the area. ### What is a historic hotel like in Medical District? > Guests who book a historic hotel can spend a night or two someplace that has an officially recognized national historic designation. A castle, a palace or even a pub or an old police station can be turned into a historic hotel as long as it has special significance. Traditional architecture and period features are often found in the guestrooms or communal spaces of these historic hotels in Medical District, giving a sense of history. ### What is the difference between a historic hotel and a heritage hotel? > "Heritage hotel" is a term often used in Asia and Europe, while "historic hotel" is a term often used in the U.S. though overall the terms are quite similar. The architecture and actual building of a historic hotel is generally what's most important. For a heritage hotel, often it's the cultural value as well as how it shaped the community. ### Do historic hotels in Medical District have modern facilities? > Hotels include modern conveniences and safety features you've come to expect, but every effort is made to preserve historic facades and treasured traditions. Smart TVs, WiFi, updated bathroom facilities, and the popular amenities found in any hotel should be available at a historic hotel. Rest assured that when you select a historic hotel in Medical District, you won't find a place that's uncomfortable or rundown. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [3 Star Hotels in Grifton](https://www.expedia.ca/3Star-Grifton-Hotels.s30-0-d3000450401.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Ayden](https://www.expedia.ca/Ayden-Hotels-Cheap-Hotels.0-0-d3000422385-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Ayden](https://www.expedia.ca/Ayden-Hotels-Luxury-Hotel.0-0-d3000422385-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Ayden Hotels](https://www.expedia.ca/Ayden-Hotels.d3000422385.Travel-Guide-Hotels) - [Bear Grass Hotels](https://www.expedia.ca/Bear-Grass-Hotels.d553248634999126074.Travel-Guide-Hotels) - [Bethel Hotels](https://www.expedia.ca/Bethel-Hotels.d3000450221.Travel-Guide-Hotels) - [Inns in Bethel](https://www.expedia.ca/Bethel-Inns.d3000450221-aaInns.Travel-Guide-Accommodation) - 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