Title: Book the Best BUSINESS Hotels in Medical District in 2025 | Expedia.ca [Medical District Travel Guide](https://expedia.ca/Greenville-Medical-District.dx908649044914896896)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d2779.Travel-Guide-VacationRentals)[Flights to Greenville](https://expedia.ca/Cheap-Flights-To-Greenville.d2779.Travel-Guide-Flights)[Medical District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-District.d908649044914896896.Car-Rental-Guide)[Medical District Vacations](https://expedia.ca/Medical-District.d908649044914896896.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Medical District, NC from CA $148 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical District Business Hotels Tonight [Oct 5 - Oct 6](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-05&endDate=2025-10-06&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-06&endDate=2025-10-07&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-10&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=908649044914896896&startDate=2025-10-17&endDate=2025-10-19&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical District Business Hotels ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/d19b7bd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/8fc50c3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/feceae8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/f93c58cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Suites-Greenville Greenville 9.0/10 Wonderful (1003) "Nice suites Beautiful hotel" CA $152 CA $171 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Suites-Greenville.h296584.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/36cd8e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/90561384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![42-inch Smart TV with cable channels, TV](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/4540394d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/951ab926.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites By Hilton Greenville, NC Greenville 9.4/10 Exceptional (278) "I loved it very nice and I will stay again nice and quiet rooms and very clean!" CA $166 CA $188 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville.h90153266.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/5f6c9580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/3c804851.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/f018a95f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/504a2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn and Suites by Marriott Washington Washington 9.4/10 Exceptional (612) "Nice Hotel! " CA $165 CA $186 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Greenville-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Washington.h18068553.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/1f6092e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/b26d4f63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/99c73073.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/120000/119100/119042/2203e988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard Marriott Greenville Medical District 8.8/10 Excellent (871) "It was easy to access. Staff was friendly and accomodating. Room was clean and comfortable " CA $183 CA $207 total includes taxes & fees Oct 17 - Oct 18 [](https://www.expedia.ca/Greenville-Hotels-Courtyard-Marriott-Greenville.h119042.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queen beds non smoking](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/9c141e18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/ea4d109f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/2472bd66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Washington Washington 8.2/10 Very good (633) "Great facility. Best in Washington " CA $153 CA $164 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2557x3y3-9ca87b37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2415x3y3-72322295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3840h2556x0y4-0c33f88e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3840h2557x0y3-6eee03ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden INN Greenville University Uptown Greenville 9.4/10 Exceptional (74) "Rhe hotel was extremely clean and nice. I will definitely stay again." CA $189 CA $213 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Greenville-Hotels-Hilton-Garden-INN-Greenville-University.h108395066.Hotel-Information) ![Suite, 1 Bedroom, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/d55c4c6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/5a87c84b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/0f38728e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/70000/62400/62311/9dd3e245.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Greenville, NC Winterville 7.6/10 Good (793) "Had a good stay here " CA $129 CA $148 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Country-Inn-Suites-By-Radisson.h62311.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/30d4a3d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/faaccec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, cribs/infant beds](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/c98c2c60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/e3500d9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Greenville by IHG Greenville 8.4/10 Very good (942) "We will definitely stay there again!" CA $138 CA $156 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Greenville-Hotels-Holiday-Inn-Express-Greenville.h102482.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12900/12870/8d14df71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12900/12870/6d7fbebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/12900/12870/d37ee56a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12900/12870/ab2264fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Greenville by IHG Greenville 8.8/10 Excellent (1001) "Property was nice and well kept. Breakfast was good though not a lot of choice." CA $155 CA $175 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Greenville-Hotels-Holiday-Inn-Greenville.h12870.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/03136946.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/9a1f8379.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/3faffb2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/c12cd9d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Greenville Greenville 8.8/10 Excellent (434) "Our room was neat and clean. Staff was very nice and breakfast buffet had a great selection." CA $165 CA $186 total includes taxes & fees Oct 9 - Oct 10 [](https://www.expedia.ca/Greenville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville.h20392562.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-19&endDate=2025-10-20®ionId=908649044914896896&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Medical District Hotel Reviews ![Holiday Inn Express Greenville by IHG](//images.trvl-media.com/lodging/1000000/110000/102500/102482/30d4a3d9_y.jpg) ### Holiday Inn Express Greenville by IHG 10/10 Excellent "Staff was friendly!" [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Express-Greenville.h102482.Hotel-Information) ![Residence Inn by Marriott Greenville](//images.trvl-media.com/lodging/7000000/6060000/6057700/6057673/f8514e6b_y.jpg) ### Residence Inn by Marriott Greenville 10/10 Excellent "The establishment was clean. The staff was absolutely amazing. I would definitely recommend this location tonight at 10 I will be returning" [](https://expedia.ca/Greenville-Hotels-Residence-Inn-Greenville.h6057673.Hotel-Information) ![Comfort Inn & Suites Greenville Near Convention Center](//images.trvl-media.com/lodging/1000000/220000/217400/217352/2d5a6141_y.jpg) ### Comfort Inn & Suites Greenville Near Convention Center 10/10 Excellent "Clean room, friendly staff, multiple great restaurants close by as well as shopping" [](https://expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville.h217352.Hotel-Information) ![Microtel Inn & Suites by Wyndham Greenville/University Medic](//images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/2e252281_y.jpg) ### Microtel Inn & Suites by Wyndham Greenville/University Medic 10/10 Excellent "We had accessible rm 1st floor. Had to complain several times abouut room above us Like a herd of elephants for several hrs. Even after 9pm" [](https://expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-GreenvilleUniversity-Medic.h2009531.Hotel-Information) ![Best Western Plus Suites-Greenville](//images.trvl-media.com/lodging/1000000/300000/296600/296584/d19b7bd8_y.jpg) ### Best Western Plus Suites-Greenville 10/10 Excellent "If you don’t like the smell of fabuloso stay away! Hotel has been updated, clean, comfortable beds, nice size rooms, good breakfast. Staff not very friendly and you MUST be out by 11am! " [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Suites-Greenville.h296584.Hotel-Information) ![Hampton Inn Washington](//images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742_y.jpg) ### Hampton Inn Washington 10/10 Excellent "Great facility. Best in Washington " [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Holiday Inn Greenville by IHG](//images.trvl-media.com/lodging/1000000/20000/12900/12870/8d14df71_y.jpg) ### Holiday Inn Greenville by IHG 10/10 Excellent "Property was nice and well kept. Breakfast was good though not a lot of choice." [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Greenville.h12870.Hotel-Information) ![Fairfield Inn and Suites by Marriott Washington](//images.trvl-media.com/lodging/19000000/18070000/18068600/18068553/5f6c9580_y.jpg) ### Fairfield Inn and Suites by Marriott Washington 10/10 Excellent "Convenient " [](https://expedia.ca/Greenville-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Washington.h18068553.Hotel-Information) ![Country Inn & Suites by Radisson, Greenville, NC](//images.trvl-media.com/lodging/1000000/70000/62400/62311/d55c4c6b_y.jpg) ### Country Inn & Suites by Radisson, Greenville, NC 10/10 Excellent "It was a great stay and service was great." 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