Title: Hotels by Wyndham Extra Holidays in Medical Center District | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/8f3b15d1d7d73e712570109708f4e829.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Linda Cronan # Find Hotels by Wyndham Extra Holidays in Medical Center District ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-20&endDate=2025-10-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center District Wyndham Extra Holidays Hotels ![Standard Condo, 1 Bedroom, Non Smoking, Kitchen | Balcony](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/d6949c80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/0c3e991c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/b7e8a2d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Condo, 2 Bedrooms, Non Smoking, Kitchen](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/49fa5475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Wyndham La Cascada Downtown San Antonio 8.4/10 Very good (180) "My family and I had a lovely weekend. The view from my balcony was so beautiful and very peaceful. Overall wonderful stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly [](https://www.expedia.ca/San-Antonio-Hotels-Club-Wyndham-La-Cascada.h2256185.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/3c527dad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/80a9b492.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/w3733h5576x0y0-6e1c4d9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Condo, 2 Bedrooms, Non Smoking | Private kitchen](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/9386f56d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Wyndham Riverside Suites Downtown San Antonio 7.6/10 Good (91) "Would stay again and recommend to anyone. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rodrigo [](https://www.expedia.ca/San-Antonio-Hotels-Club-Wyndham-Riverside-Suites.h1047721.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-02&endDate=2025-11-03®ionId=553248635978913844&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Wyndham-Extra-Holidays.0-n553248635978913844-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Wyndham-Extra-Holidays.0-n553248635978913844-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) ## Top Medical Center District Hotel Reviews ![The Westin San Antonio North](//images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6_y.jpg) ### The Westin San Antonio North 10/10 Excellent "Room was clean, be comfortable and very quiet." [](https://expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) ![Drury Plaza Hotel San Antonio Riverwalk](//images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg) ### Drury Plaza Hotel San Antonio Riverwalk 10/10 Excellent "The hotel was great. Clean, food was excellent and the staff was very friendly and helpful." [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Spark By Hilton San Antonio Northwest near Six Flags](//images.trvl-media.com/lodging/1000000/50000/41300/41271/9e3e8920_y.jpg) ### Spark By Hilton San Antonio Northwest near Six Flags 10/10 Excellent "Amazing so far " [](https://expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information) ![Hotel Contessa](//images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg) ### Hotel Contessa 10/10 Excellent "Great staff" [](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information) ![Crockett Hotel](//images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6_y.jpg) ### Crockett Hotel 10/10 Excellent "Fabulous place to stay, highly recommend " [](https://expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Riverwalk Plaza](//images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg) ### Riverwalk Plaza 10/10 Excellent "Air conditioner was okay it could've been better " [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](//images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Friendly and helpful staff. Walk to the Riverwalk and The Alamo. Excellent rooms. Hot breakfast (free).Spendy parking. " [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Canopy by Hilton San Antonio Riverwalk](//images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/04916744_y.jpg) ### Canopy by Hilton San Antonio Riverwalk 10/10 Excellent "The experience I expected to have in San Antonio was exceeded with such an amazing place to stay for it." [](https://expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information) ![Hyatt Vacation Club at Wild Oak Ranch, San Antonio](//images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/5058d5ba_y.jpg) ### Hyatt Vacation Club at Wild Oak Ranch, San Antonio 10/10 Excellent "A perfect gateway from the city." [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) ## Find out more about Medical Center District ## Medical Center District Hotels Guide Expedia.ca offers a selection of 4665 hotels in Medical Center District. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Medical Center District. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Medical Center District neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Medical Center District, San Antonio now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [3 Star Hotels in Woodridge](https://www.expedia.ca/3Star-Woodridge-San-Antonio-Hotels.s30-n553248635976386203-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Northwest Side](https://www.expedia.ca/5Star-Northwest-Side-San-Antonio-Hotels.s50-n887264728595001344-0.Travel-Guide-Filter-Hotels) - [Omni Hotels in Alamo Plaza](https://www.expedia.ca/Alamo-Plaza-Hotels-Omni.0-0-d6229132--bOmni.Travel-Guide-Filter-Hotels) - [Hotels near Alamo Quarry Market](https://www.expedia.ca/Alamo-Quarry-Market-Hotels.0-l6163147-0.Travel-Guide-Filter-Hotels) - [Babcock North Hotels](https://www.expedia.ca/Babcock-North-San-Antonio-Hotels.0-n553248635976474646-0.Travel-Guide-Filter-Hotels) - [Hotels near Bandera Road Community Church](https://www.expedia.ca/Bandera-Road-Community-Church-Hotels.0-l553248621532643314-0.Travel-Guide-Filter-Hotels) - 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[La Quinta Inn & Suites Hotels in San Antonio](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites.0-0-d178303--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [San Antonio Hotels](https://www.expedia.ca/San-Antonio-Hotels.d178303.Travel-Guide-Hotels) - [Shavano Park Hotels](https://www.expedia.ca/Shavano-Park-San-Antonio-Hotels.0-n6004947-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Shearer Hills - Ridgeview](https://www.expedia.ca/Shearer-Hills-Ridgeview-San-Antonio-Hotels-Adults-Only-Resorts.0-n553248635976471907-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Hotels near South Texas Medical Center](https://www.expedia.ca/South-Texas-Medical-Center-Hotels.0-l6193120-0.Travel-Guide-Filter-Hotels) - [Extended Stay America Hotels in Southside](https://www.expedia.ca/Southside-Hotels-Extended-Stay-America.0-0-d553248635939576783--bExtendedStayAmerica.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Southside](https://www.expedia.ca/Southside-Hotels-Marriott-Hotels-Resorts.0-0-d553248635939576783--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Southside](https://www.expedia.ca/Southside-Hotels-Motel-6.0-0-d553248635939576783--bMotel6.Travel-Guide-Filter-Hotels) - [Hotels near St. Mary's University](https://www.expedia.ca/St-Marys-University-Hotels.0-l502632-0.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Terrell Heights](https://www.expedia.ca/Terrell-Heights-San-Antonio-Hotels-Wyndham-Extra-Holidays.0-n553248635976474095-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Hilton Hotels in The Dominion](https://www.expedia.ca/The-Dominion-San-Antonio-Hotels-Hilton-Hotels.0-n6338712-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Hotels near USAA Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Hotels.0-l553248621593511346-0.Travel-Guide-Filter-Hotels) - [Hotels near University of Texas Health and Science Center at San Antonio](https://www.expedia.ca/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Hotels.0-l6191585-0.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Marriott-Hotels-Resorts.0-n553248635974902947-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Omni Hotels in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Omni.0-n553248635974902947-0--bOmni.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Vance Jackson](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Vance Jackson Hotels](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels) - [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in West San Antonio](https://www.expedia.ca/West-San-Antonio-Hotels-Motel-6.0-0-d553248633938962774--bMotel6.Travel-Guide-Filter-Hotels) - [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Flights from Edmonton (YEG) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yeg/sat/edmonton-to-san-antonio) - [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio) - [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio) - [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio) - [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction) - [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368) - [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679) - [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419) - [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858) - [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction) - [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide) - [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide) - [Book Hotels in Medical Center District on Expedia.com](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels-Wyndham-Extra-Holidays.0-n553248635978913844-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels)