Title: Hotels by Wyndham Extra Holidays in Medical Center District  | Expedia.ca

  

[Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides)

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# Find Hotels by Wyndham Extra Holidays in Medical Center District

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## Check prices for these dates

Tonight

[Oct 31 - Nov 1](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-31&endDate=2025-11-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-11-01&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Medical Center District Wyndham Extra Holidays Hotels

![Property amenity](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/b7e8a2d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/0c3e991c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Condo, 2 Bedrooms, Non Smoking, Kitchen](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/49fa5475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/3000000/2260000/2256200/2256185/5f1a55dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Club Wyndham La Cascada

Downtown San Antonio

8.4/10

Very good

(180)

"Clean, great location, great customer service"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Terry

[](https://www.expedia.ca/San-Antonio-Hotels-Club-Wyndham-La-Cascada.h2256185.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/3c527dad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/w3733h5576x0y0-6e1c4d9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Studio Suite, Non Smoking | Private kitchenette](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/cabc5604.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/2000000/1050000/1047800/1047721/80a9b492.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Club Wyndham Riverside Suites

Downtown San Antonio

7.6/10

Good

(91)

"Awesome location along the Riverwalk! Loved the available patio to relax at. Our room was nicer than we expected it to be!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cayetano

[](https://www.expedia.ca/San-Antonio-Hotels-Club-Wyndham-Riverside-Suites.h1047721.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Medical Center District Hotel Reviews

![Drury Plaza Hotel San Antonio Riverwalk](//images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg)

### Drury Plaza Hotel San Antonio Riverwalk

10/10 Excellent

"This was such fantastic hotel. The staff was great I honestly wish we could have stayed longer"

[](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information)

![Spark By Hilton San Antonio Northwest near Six Flags](//images.trvl-media.com/lodging/1000000/50000/41300/41271/9e3e8920_y.jpg)

### Spark By Hilton San Antonio Northwest near Six Flags

10/10 Excellent

"Good"

[](https://expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information)

![Sonesta ES Suites San Antonio Downtown Alamo Plaza](//images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg)

### Sonesta ES Suites San Antonio Downtown Alamo Plaza

10/10 Excellent

"Great"

[](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information)

![Canopy by Hilton San Antonio Riverwalk](//images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/04916744_y.jpg)

### Canopy by Hilton San Antonio Riverwalk

10/10 Excellent

"Very good "

[](https://expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

![Riverwalk Plaza](//images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg)

### Riverwalk Plaza

10/10 Excellent

"Fantastic lobby with tons of entertainment options."

[](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![Hotel Contessa](//images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg)

### Hotel Contessa

10/10 Excellent

"Very friendly and helpful staff. Huge rooms. "

[](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information)

![Omni La Mansion del Rio](//images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955_y.jpg)

### Omni La Mansion del Rio

10/10 Excellent

"Great place, right on the riverwalk with easy access. We stayed for our wedding anniversary and the hotel provided champagne and chocolate covered strawberries. "

[](https://expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information)

![Fairfield Inn & Suites by Marriott San Antonio Medical Center](//images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/3a049706_y.jpg)

### Fairfield Inn & Suites by Marriott San Antonio Medical Center

10/10 Excellent

"Breakfast is always great and hotel is always clean and relaxing "

[](https://expedia.ca/San-Antonio-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Antonio-Medical-Center.h68847371.Hotel-Information)

![San Antonio Marriott Northwest Medical Center](//images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de_y.jpg)

### San Antonio Marriott Northwest Medical Center

10/10 Excellent

"Everything was good "

[](https://expedia.ca/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information)

## Find out more about Medical Center District

## Medical Center District Hotels Guide

Expedia.ca offers a selection of 4630 hotels in Medical Center District. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs.

Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Medical Center District. Making reservations so you can stay within your budget is easy with us.

Expedia.ca even provides you with a map so you may find hotels in the Medical Center District neighborhood you prefer.

Go ahead. Enter your travel dates to view the best offers on hotel rooms in Medical Center District, San Antonio now!

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-   [Hotels near St. Mary's University](https://www.expedia.ca/St-Marys-University-Hotels.0-l502632-0.Travel-Guide-Filter-Hotels)
-   [Wyndham Extra Holidays Hotels in Terrell Heights](https://www.expedia.ca/Terrell-Heights-San-Antonio-Hotels-Wyndham-Extra-Holidays.0-n553248635976474095-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels)
-   [Hilton Hotels in The Dominion](https://www.expedia.ca/The-Dominion-San-Antonio-Hotels-Hilton-Hotels.0-n6338712-0--bHiltonHotels.Travel-Guide-Filter-Hotels)
-   [Hotels near USAA Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Hotels.0-l553248621593511346-0.Travel-Guide-Filter-Hotels)
-   [Hotels near University of Texas Health and Science Center at San Antonio](https://www.expedia.ca/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Hotels.0-l6191585-0.Travel-Guide-Filter-Hotels)
-   [Marriott Hotels & Resorts in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Marriott-Hotels-Resorts.0-n553248635974902947-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels)
-   [Omni Hotels in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Omni.0-n553248635974902947-0--bOmni.Travel-Guide-Filter-Hotels)
-   [All Inclusive Resorts and in Vance Jackson](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
-   [Vance Jackson Hotels](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels)
-   [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels)
-   [Motel 6 Hotels in West San Antonio](https://www.expedia.ca/West-San-Antonio-Hotels-Motel-6.0-0-d553248633938962774--bMotel6.Travel-Guide-Filter-Hotels)
-   [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels)
-   [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels)

-   [Flights from Edmonton (YEG) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yeg/sat/edmonton-to-san-antonio)
-   [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio)
-   [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio)
-   [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio)

-   [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction)
-   [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368)
-   [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679)
-   [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419)
-   [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858)
-   [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction)

-   [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide)
-   [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide)

-   [Book Hotels in Medical Center District on Expedia.com](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels-Wyndham-Extra-Holidays.0-n553248635978913844-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels)