Title: Hotels by Omni in Medical Center District from CA $274 | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/8f3b15d1d7d73e712570109708f4e829.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Linda Cronan # Find Hotels by Omni in Medical Center District from CA $274 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-11-02&endDate=2025-11-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-11-03&endDate=2025-11-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center District Omni Hotels ![Balcony view](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds | View from room](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a20972d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a1a78274.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/aca78f83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni La Mansion del Rio Downtown San Antonio 9.4/10 Exceptional (2745) "Awesome place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alex CA $229 CA $274 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information) ![Water view](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/40020cde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/14047936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/44e7c0ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Balcony (Luxury Spa Room) | Balcony view](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/e749b075.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mokara Hotel & Spa San Antonio Downtown San Antonio 9.6/10 Exceptional (1014) "Exceptional service, clean and modern rooms, front desk was welcoming and helpful! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy CA $344 CA $407 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/San-Antonio-Hotels-Mokara-Hotel-Spa-San-Antonio.h988490.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-17&endDate=2025-11-18®ionId=553248635978913844&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Omni.0-n553248635978913844-0--bOmni.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Omni.0-n553248635978913844-0--bOmni.Travel-Guide-Filter-Hotels) ## Top Medical Center District Hotel Reviews ![San Antonio Marriott Northwest Medical Center](//images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de_y.jpg) ### San Antonio Marriott Northwest Medical Center 10/10 Excellent "Nice views" [](https://expedia.ca/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) ![Hotel Contessa](//images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg) ### Hotel Contessa 10/10 Excellent "All good " [](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information) ![Crockett Hotel](//images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6_y.jpg) ### Crockett Hotel 10/10 Excellent "Best location!!! " [](https://expedia.ca/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Menger Hotel](//images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6_y.jpg) ### Menger Hotel 10/10 Excellent "We loved this hotel, the history, the architecture, the lore, the pool, the courtyard, it really was magical. The location also couldn’t be beat it’s right next door to the Alamo and the riverwalk, tons of great shopping and food nearby all walkable. The rooms were so comfortable we had a view of the pool and giant palm trees " [](https://expedia.ca/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) ![Drury Plaza Hotel San Antonio Riverwalk](//images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg) ### Drury Plaza Hotel San Antonio Riverwalk 10/10 Excellent "This was such fantastic hotel. The staff was great I honestly wish we could have stayed longer" [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Hyatt Regency San Antonio Riverwalk](//images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg) ### Hyatt Regency San Antonio Riverwalk 10/10 Excellent "Room great. Staff Stupendous!" [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information) ![Spark By Hilton San Antonio Northwest near Six Flags](//images.trvl-media.com/lodging/1000000/50000/41300/41271/9e3e8920_y.jpg) ### Spark By Hilton San Antonio Northwest near Six Flags 10/10 Excellent "Good" [](https://expedia.ca/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](//images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Great" [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Canopy by Hilton San Antonio Riverwalk](//images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/04916744_y.jpg) ### Canopy by Hilton San Antonio Riverwalk 10/10 Excellent "Very good " [](https://expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information) ## Find out more about Medical Center District ## Medical Center District Hotels Guide Expedia.ca offers a selection of 4604 hotels in Medical Center District. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Medical Center District. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Medical Center District neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Medical Center District, San Antonio now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [3 Star Hotels in Woodridge](https://www.expedia.ca/3Star-Woodridge-San-Antonio-Hotels.s30-n553248635976386203-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Northwest Side](https://www.expedia.ca/5Star-Northwest-Side-San-Antonio-Hotels.s50-n887264728595001344-0.Travel-Guide-Filter-Hotels) - [Omni Hotels in Alamo Plaza](https://www.expedia.ca/Alamo-Plaza-Hotels-Omni.0-0-d6229132--bOmni.Travel-Guide-Filter-Hotels) - [Hotels near Alamo Quarry Market](https://www.expedia.ca/Alamo-Quarry-Market-Hotels.0-l6163147-0.Travel-Guide-Filter-Hotels) - [Babcock North Hotels](https://www.expedia.ca/Babcock-North-San-Antonio-Hotels.0-n553248635976474646-0.Travel-Guide-Filter-Hotels) - [Hotels near Bandera Road Community Church](https://www.expedia.ca/Bandera-Road-Community-Church-Hotels.0-l553248621532643314-0.Travel-Guide-Filter-Hotels) - 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[La Quinta Inn & Suites Hotels in San Antonio](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites.0-0-d178303--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [San Antonio Hotels](https://www.expedia.ca/San-Antonio-Hotels.d178303.Travel-Guide-Hotels) - [Shavano Park Hotels](https://www.expedia.ca/Shavano-Park-San-Antonio-Hotels.0-n6004947-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Shearer Hills - Ridgeview](https://www.expedia.ca/Shearer-Hills-Ridgeview-San-Antonio-Hotels-Adults-Only-Resorts.0-n553248635976471907-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Hotels near South Texas Medical Center](https://www.expedia.ca/South-Texas-Medical-Center-Hotels.0-l6193120-0.Travel-Guide-Filter-Hotels) - [Extended Stay America Hotels in Southside](https://www.expedia.ca/Southside-Hotels-Extended-Stay-America.0-0-d553248635939576783--bExtendedStayAmerica.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Southside](https://www.expedia.ca/Southside-Hotels-Marriott-Hotels-Resorts.0-0-d553248635939576783--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Southside](https://www.expedia.ca/Southside-Hotels-Motel-6.0-0-d553248635939576783--bMotel6.Travel-Guide-Filter-Hotels) - [Hotels near St. Mary's University](https://www.expedia.ca/St-Marys-University-Hotels.0-l502632-0.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Terrell Heights](https://www.expedia.ca/Terrell-Heights-San-Antonio-Hotels-Wyndham-Extra-Holidays.0-n553248635976474095-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Hilton Hotels in The Dominion](https://www.expedia.ca/The-Dominion-San-Antonio-Hotels-Hilton-Hotels.0-n6338712-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Hotels near USAA Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Hotels.0-l553248621593511346-0.Travel-Guide-Filter-Hotels) - [Hotels near University of Texas Health and Science Center at San Antonio](https://www.expedia.ca/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Hotels.0-l6191585-0.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Marriott-Hotels-Resorts.0-n553248635974902947-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Omni Hotels in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Omni.0-n553248635974902947-0--bOmni.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Vance Jackson](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Vance Jackson Hotels](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels) - [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in West San Antonio](https://www.expedia.ca/West-San-Antonio-Hotels-Motel-6.0-0-d553248633938962774--bMotel6.Travel-Guide-Filter-Hotels) - [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Flights from Edmonton (YEG) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yeg/sat/edmonton-to-san-antonio) - [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio) - [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio) - [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio) - [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction) - [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368) - [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679) - [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419) - [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858) - [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction) - [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide) - [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide) - [Book Hotels in Medical Center District on Expedia.com](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels-Omni.0-n553248635978913844-0--bOmni.Travel-Guide-Filter-Hotels)