Title: Hotels by Omni in Medical Center District from CA $274 | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/8f3b15d1d7d73e712570109708f4e829.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Linda Cronan # Find Hotels by Omni in Medical Center District from CA $274 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center District Omni Hotels ![Balcony view](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/67b863e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/aca78f83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a1a78274.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni La Mansion del Rio Downtown San Antonio 9.4/10 Exceptional (2730) "Loved everything about the hotel and location would stay again. " CA $229 CA $274 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information) ![Water view](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/40020cde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/14047936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/44e7c0ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Balcony (Luxury Spa Room)](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/9082aab5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mokara Hotel & Spa San Antonio Downtown San Antonio 9.6/10 Exceptional (1005) "Exceptional service, clean and modern rooms, front desk was welcoming and helpful! " CA $343 CA $407 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-Mokara-Hotel-Spa-San-Antonio.h988490.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-26&endDate=2025-10-27®ionId=553248635978913844&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Omni.0-n553248635978913844-0--bOmni.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Omni.0-n553248635978913844-0--bOmni.Travel-Guide-Filter-Hotels) ## Top Medical Center District Hotel Reviews ![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](//images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW 10/10 Excellent "Exlente servicio " [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![Grand Hyatt San Antonio River Walk](//images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/289c4b24_y.jpg) ### Grand Hyatt San Antonio River Walk 10/10 Excellent "Love the location! Hotel was very nice! Staff was just okay." [](https://expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information) ![Riverwalk Plaza](//images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg) ### Riverwalk Plaza 10/10 Excellent "Great hotel. Affordable price. Amazing staff and great activities around the hotel. Rooms are nice and clean." [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![Courtyard by Marriott Medical Center San Antonio](//images.trvl-media.com/lodging/1000000/20000/12600/12556/2045bf85_y.jpg) ### Courtyard by Marriott Medical Center San Antonio 10/10 Excellent "Clean room and quiet hotel comfortable beds. Nice courtyard also" [](https://expedia.ca/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](//images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Good over all. Room size was perfect with full kitchen and seperate bedroom. Only issue was tub would take long to drain." [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![The Westin Riverwalk, San Antonio](//images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg) ### The Westin Riverwalk, San Antonio 10/10 Excellent "The staff were incredibly nice and accommodating." [](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information) ![The Westin San Antonio North](//images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6_y.jpg) ### The Westin San Antonio North 10/10 Excellent "I did not have time for gym. Staff was excellent! I felt safe and comfortable. Love the Starbucks coffee every morning! I have stayed a total of 4 times. That should tell you something! " [](https://expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) ![Hyatt Regency San Antonio Riverwalk](//images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg) ### Hyatt Regency San Antonio Riverwalk 10/10 Excellent "Relaxing stay. " [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information) ![Hotel Valencia Riverwalk](//images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg) ### Hotel Valencia Riverwalk 10/10 Excellent "Room was perfect!" [](https://expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ## Find out more about Medical Center District ## Medical Center District Hotels Guide Expedia.ca offers a selection of 4656 hotels in Medical Center District. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Medical Center District. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Medical Center District neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Medical Center District, San Antonio now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [3 Star Hotels in Woodridge](https://www.expedia.ca/3Star-Woodridge-San-Antonio-Hotels.s30-n553248635976386203-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Northwest Side](https://www.expedia.ca/5Star-Northwest-Side-San-Antonio-Hotels.s50-n887264728595001344-0.Travel-Guide-Filter-Hotels) - [Omni Hotels in Alamo Plaza](https://www.expedia.ca/Alamo-Plaza-Hotels-Omni.0-0-d6229132--bOmni.Travel-Guide-Filter-Hotels) - [Hotels near Alamo Quarry Market](https://www.expedia.ca/Alamo-Quarry-Market-Hotels.0-l6163147-0.Travel-Guide-Filter-Hotels) - [Babcock North Hotels](https://www.expedia.ca/Babcock-North-San-Antonio-Hotels.0-n553248635976474646-0.Travel-Guide-Filter-Hotels) - [Hotels near Bandera Road Community Church](https://www.expedia.ca/Bandera-Road-Community-Church-Hotels.0-l553248621532643314-0.Travel-Guide-Filter-Hotels) - 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[La Quinta Inn & Suites Hotels in San Antonio](https://www.expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites.0-0-d178303--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [San Antonio Hotels](https://www.expedia.ca/San-Antonio-Hotels.d178303.Travel-Guide-Hotels) - [Shavano Park Hotels](https://www.expedia.ca/Shavano-Park-San-Antonio-Hotels.0-n6004947-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Shearer Hills - Ridgeview](https://www.expedia.ca/Shearer-Hills-Ridgeview-San-Antonio-Hotels-Adults-Only-Resorts.0-n553248635976471907-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Hotels near South Texas Medical Center](https://www.expedia.ca/South-Texas-Medical-Center-Hotels.0-l6193120-0.Travel-Guide-Filter-Hotels) - [Extended Stay America Hotels in Southside](https://www.expedia.ca/Southside-Hotels-Extended-Stay-America.0-0-d553248635939576783--bExtendedStayAmerica.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Southside](https://www.expedia.ca/Southside-Hotels-Marriott-Hotels-Resorts.0-0-d553248635939576783--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - 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[Marriott Hotels & Resorts in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Marriott-Hotels-Resorts.0-n553248635974902947-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Omni Hotels in Uptown](https://www.expedia.ca/Uptown-San-Antonio-Hotels-Omni.0-n553248635974902947-0--bOmni.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Vance Jackson](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Vance Jackson Hotels](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels) - [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in West San Antonio](https://www.expedia.ca/West-San-Antonio-Hotels-Motel-6.0-0-d553248633938962774--bMotel6.Travel-Guide-Filter-Hotels) - [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Flights from Edmonton (YEG) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yeg/sat/edmonton-to-san-antonio) - [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio) - [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio) - [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio) - [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction) - [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368) - [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679) - [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419) - [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858) - [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction) - [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide) - [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide) - [Book Hotels in Medical Center District on Expedia.com](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels-Omni.0-n553248635978913844-0--bOmni.Travel-Guide-Filter-Hotels)