Title: Hotels by Motel 6 in Medical Center District from CA $65 | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![SanAntonio_SouthTexasMedicalCenter_6193120_01](https://images.trvl-media.com/place/6193120/6208bc73-d0ab-4fda-b1af-d2c1bae086ed.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Motel 6 in Medical Center District from CA $65 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-12&endDate=2025-12-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Medical Center District Motel 6 ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/9020de3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/2aeb4fd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/bb907d9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/990000/981000/980982/898dfa9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - West SeaWorld [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h980982.Hotel-Information) Far West Side 6.0/10 (1003) "Parking was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) courtney CA $58 CA $69 total includes taxes & fees Dec 13 - Dec 14 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h980982.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996181/714394f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/1000000/996200/996181/83a7204c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996200/996181/4b8e8065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/996200/996181/c362da4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - Fiesta [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h996181.Hotel-Information) La Cantera District 6.6/10 (1004) "We liked it the location is great. And knowing that after four times we will get a discount. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anna CA $57 CA $67 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h996181.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037730/7c008e9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037730/d0ddee43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037730/c121f38c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Accessible bathroom](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037730/7aea1b7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - Downtown - Alamo Dome [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h1037730.Hotel-Information) San Antonio 7.0/10 Good (1001) "Everything was good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) April CA $72 CA $84 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h1037730.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/990000/983700/983643/1c1ca9be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/990000/983700/983643/03d7e341.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/990000/983700/983643/55c590c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983643/c9d05a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - Downtown - Market Square [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h983643.Hotel-Information) San Antonio 6.8/10 (1002) "Place was disgusting and in a homeless area it was convenient to everything but was not in a safe place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MaryAnn CA $76 CA $90 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h983643.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/870000/861400/861330/bca9c3eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, cookware/dishes/utensils](https://images.trvl-media.com/lodging/1000000/870000/861400/861330/a45742da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/870000/861400/861330/1780a792.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/870000/861400/861330/ac03244a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 San Antonio, TX - Airport [](https://www.expedia.ca/San-Antonio-Hotels-Studio-6-San-Antonio.h861330.Hotel-Information) Uptown 6.2/10 (1010) "Yes the room looked really trashy nothing like the pictures online. Drug Dealing and the guys next to our room were selling and smoke weed. But i will never stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ignacio [](https://www.expedia.ca/San-Antonio-Hotels-Studio-6-San-Antonio.h861330.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/14200/14170/4164246d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/14200/14170/bf3a81a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/14200/14170/d1f3a703.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/14200/14170/76c96a52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - Fiesta Trails [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h14170.Hotel-Information) Vance Jackson 6.6/10 (979) "Our stay was very pleasant. TY ANNA FOR OUR CHECK-IN" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joben CA $62 CA $72 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h14170.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1120000/1112600/1112532/de02c33e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Library](https://images.trvl-media.com/lodging/2000000/1120000/1112600/1112532/e2c3fe2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1120000/1112600/1112532/c16c9711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1120000/1112600/1112532/10537c13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, Tx - Frost Bank Center [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h1112532.Hotel-Information) Arena District 5.8/10 (412) "Was good staying " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Enrique CA $61 CA $71 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h1112532.Hotel-Information) ![Deluxe Room, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/5000000/4610000/4608400/4608372/df0b7821.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/5000000/4610000/4608400/4608372/840cac1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/5000000/4610000/4608400/4608372/a574eeef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4610000/4608400/4608372/08190e0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX – I-35 North Corridor [](https://www.expedia.ca/San-Antonio-Hotels-Red-Roof-Inn-San-Antonio-I-35-North.h4608372.Hotel-Information) Uptown 6.8/10 (112) "Room was clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) blanca CA $56 CA $65 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/San-Antonio-Hotels-Red-Roof-Inn-San-Antonio-I-35-North.h4608372.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1470000/1469300/1469223/5ab76002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1470000/1469300/1469223/59e46264.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1470000/1469300/1469223/cfd04f4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1470000/1469300/1469223/80d9ac3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - Sea World North [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h1469223.Hotel-Information) Far West Side 6.8/10 (558) "Great stay. Quiet and peaceful. Staff were very friendly and helpful. Fantastic if you are looking for a safe haven and cleanliness for your family and kids. Allowances for pets, though I didn’t specify amounts. You will be glad you chose them." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $70 CA $82 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h1469223.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/5f526f3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/33c180e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/8b9aed83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/ef1bc714.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - Northwest Medical Center [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information) Medical Center District 6.0/10 (1000) "Really enjoyed our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ernest CA $59 CA $70 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27®ionId=553248635978913844&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Motel-6.0-n553248635978913844-0--bMotel6.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-District-San-Antonio-Hotels-Motel-6.0-n553248635978913844-0--bMotel6.Travel-Guide-Filter-Hotels) ## Top Medical Center District Hotel Reviews ![Omni La Mansion del Rio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955_y.jpg) ### Omni La Mansion del Rio 10/10 Excellent "Excellent services !!! I recommend " [](https://expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information) ![AC Hotel by Marriott San Antonio Riverwalk](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/eb0c229a_y.jpg) ### AC Hotel by Marriott San Antonio Riverwalk 10/10 Excellent "The space was clean , modern and cozy. The location was outstanding. The front desk was very helpful and having the wonderful rooftop bar was just chefs kiss." [](https://expedia.ca/San-Antonio-Hotels-AC-Hotel-By-Marriott-San-Antonio-Riverwalk.h64402184.Hotel-Information) ![Hampton Inn & Suites San Antonio-Airport](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489262/70cfe6ef_y.jpg) ### Hampton Inn & Suites San Antonio-Airport 10/10 Excellent "Very convenient to the airport!" [](https://expedia.ca/San-Antonio-Hotels-Hampton-Inn-Suites-San-Antonio-Airport.h1489262.Hotel-Information) ![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg) ### Riverwalk Plaza 10/10 Excellent "Clean room, soft beds, friendly service " [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg) ### Hotel Valencia Riverwalk 10/10 Excellent "The staff were all extremely helpful and very courteous. Great location on the river walk and very scenic. " [](https://expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Drury Plaza Hotel San Antonio Riverwalk](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg) ### Drury Plaza Hotel San Antonio Riverwalk 10/10 Excellent "Clean room, excellent staff, great location! Every employee we interacted with was cheerful and eager to remind us of all of the amenities available. This trip was a birthday gift to my wife, and the hotel staff really helped make our trip seem special. We had a great time!" [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Clean room. Good breakfast. Valet parking is only available if you have a car, and the rate is a bit high. We used the parking meter instead." [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk 10/10 Excellent "The room was clean, great customer service. Breakfast was very good. Connie at front desk was very nice, and patient with everyone checking in. " [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae_y.jpg) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW 10/10 Excellent "Clean room , everything looks fresh. Decent morning breakfast." [](https://expedia.ca/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ## Find out more about Medical Center District ## Medical Center District Hotels Guide Expedia.ca offers a selection of 4707 hotels in Medical Center District. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Medical Center District. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Medical Center District neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Medical Center District, San Antonio now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [3 Star Hotels in Woodridge ](https://www.expedia.ca/3Star-Woodridge-San-Antonio-Hotels.s30-n553248635976386203-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Northwest Side ](https://www.expedia.ca/5Star-Northwest-Side-San-Antonio-Hotels.s50-n887264728595001344-0.Travel-Guide-Filter-Hotels) - [Omni Hotels in Alamo Plaza ](https://www.expedia.ca/Alamo-Plaza-Hotels-Omni.0-0-d6229132--bOmni.Travel-Guide-Filter-Hotels) - [Hotels near Alamo Quarry Market ](https://www.expedia.ca/Alamo-Quarry-Market-Hotels.0-l6163147-0.Travel-Guide-Filter-Hotels) - [Babcock North Hotels ](https://www.expedia.ca/Babcock-North-San-Antonio-Hotels.0-n553248635976474646-0.Travel-Guide-Filter-Hotels) - [Hotels near Bandera Road Community Church ](https://www.expedia.ca/Bandera-Road-Community-Church-Hotels.0-l553248621532643314-0.Travel-Guide-Filter-Hotels) - 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