Title: Book the Best Medical Center District LUXURY Hotels - Upscale Hotels in Medical Center District, San Antonio | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/8f3b15d1d7d73e712570109708f4e829.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Linda Cronan # Find Luxury Hotels in Medical Center District, San Antonio ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center District Luxury Hotels Tonight [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-15&endDate=2025-10-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 16 - Oct 17](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-16&endDate=2025-10-17&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center District Luxury Hotels ## Top Medical Center District Hotel Reviews ![Hotel Valencia Riverwalk](//images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg) ### Hotel Valencia Riverwalk 10/10 Excellent "Very , very nice hotel it’s my new go to stay now. I love it." [](https://expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Menger Hotel](//images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6_y.jpg) ### Menger Hotel 10/10 Excellent "This was the first time I stayed at the Menger . It was very comfortable and right in the heart of the Alamo Plaza. The Alamo was a short walk across the street, shopping and fine dining all within a few minutes walk. The valet parking is a little expensive for me, but very convenient. They have a nice restaurant and bar downstairs, room service for the early morning breakfast in bed, and the first floor is like a little time capsule of this historic hotel. I'll come back in a future visit and stay a little longer " [](https://expedia.ca/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) ![Hotel Contessa](//images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg) ### Hotel Contessa 10/10 Excellent "Everything was wonderful with the exception of the shower and toilet. It had mold in it. " [](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information) ![Hyatt Vacation Club at Wild Oak Ranch, San Antonio](//images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/5058d5ba_y.jpg) ### Hyatt Vacation Club at Wild Oak Ranch, San Antonio 10/10 Excellent "Can’t wait to visit this jewel again!!!" [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) ![Drury Plaza Hotel San Antonio Riverwalk](//images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/232ec435_y.jpg) ### Drury Plaza Hotel San Antonio Riverwalk 10/10 Excellent "Breakfast and dinner " [](https://expedia.ca/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](//images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Wonderful property, so clean and fresh. Only tiny knock is the channel guide on the TV was wrong, but so minor! A GREAT value, just a few minutes walk to Alamo and Riverway! " [](https://expedia.ca/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![The Westin San Antonio North](//images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6_y.jpg) ### The Westin San Antonio North 10/10 Excellent "There were multiple venues going on at the same time which made for hectic and entertaining times at the hotel A Pokémon branch of comicon was surreal until I found out what was going on. Previous stays were more sedate as one would expect in primarily business oriented hotel. It is convenient to just about any place you want to see but getting onto I 10 requires a learning curve if you drive. Parking fee with no valet service was a disappointment. " [](https://expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) ![Hyatt Regency San Antonio Riverwalk](//images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg) ### Hyatt Regency San Antonio Riverwalk 10/10 Excellent "Love how it is centered on the river walk. " [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information) ![The Westin Riverwalk, San Antonio](//images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg) ### The Westin Riverwalk, San Antonio 10/10 Excellent "Eugene was fantastic ! Checked us in and gave us some pointers on what to do in the area . Phyllis was top notch too. We thank you both for a pleasant stay …❤️" [](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in Medical Center District? > Use Expedia to arrange your flight to San Antonio International Airport (SAT) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel that has a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Medical Center District offers. Medical Center District has some interesting things to see and do including USAA Corporate Office Headquarters and Cinemark San Antonio 16, so you might want to take in the local sights during your visit. ### What's there to see and do in Medical Center District? > Enjoy all that Medical Center District has to offer when you visit USAA Corporate Office Headquarters, Cinemark San Antonio 16, and The San Antonio Art Institute. 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[North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction) - [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368) - [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679) - [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419) - [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858) - [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction) - [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide) - [Book Hotels in Medical Center District on Expedia.com](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels-Luxury-Hotel.0-n553248635978913844-0-tLuxuryHotel.Travel-Guide-Filter-Hotels)